| SUNDAY |
| 2.00 pm - 9.00 pm | Arrival and check-in |
| 6.00 pm | Dinner |
| 7.30 | Opening Reception and Welcome |
| Chair:
David Begley, Kings College, London UK |
| 7.45-9.30 | Perspective Lectures |
| Chair and Discussion Leader:
Lester Drewes, University Minnesota School of Medicine, Duluth, USA |
| 7.45 | Ronald T. Borchardt, University of Kansas, Lawrence, USA
Transport Across the Intestine. Are there Lessons for the Blood-Brain Barrier? |
| 8.45 | Andreas Reichel, Schering, Berlin, Germany
The Role of Blood-Brain Barrier Studies from a Pharmaceutical Industry Perspective: Where Are We and Where Would We Like To Go? |
| 9.30 - | Posters to be mounted, further discussion and social occasion. |
| MONDAY |
| 7.30 - 8.30 | Breakfast |
| 08.30 | Group Photograph (assemble outside dining hall) |
| 9.00-12.30 | Cell and Molecular Biology of Blood-Brain Barriers |
| Chair and Discussion Leader:
Quentin Smith, Texas Tech University, Amarillo, USA. |
| 09.00 | Ruben J. Boado, University of California. Los Angeles,USA
A molecular Biological Approach to the BBB. |
| 09.30 | Berislav Zlokovic, University of Rochester, NY, USA
Functional Genomics of Brain Endothelium in Alzheimer's Disease. |
| 10.00 - 10:30 | Coffee |
| 10.30 | Anna Seelig, University of Basel, Switzerland
Predicting BBB Penetration from Physicochemical Parameters. |
| 11.00 | Ingolf Blasig, Institute for Molecular Pharmacology, Berlin, Germany
Occludin: Phosphorylation and Protein-Protein Interactions. |
| 11.30 - 12.30 | Formal Poster Session and Coffee
(Presence of poster presenters for Session 2 mandatory) |
| 12.30 | Lunch |
| Afternoon Free for activities and discussion |
| 4:00-6:00 | Piano Recital (Chapel) followed by Reception and Social Gathering |
| 6.00 | Dinner |
| 7.30-9.30 | Cell and Molecular Biology of Blood-Brain Barriers |
| Chair and Discussion Leader:
Hazel Jones, University of Florida, USA |
| 7.30 | Maria Balda, University College, London, UK.
Cell Biology of Tight Junctions. |
| 8.00 | Ole Petter Ottersen, University of Oslo, Norway
Exchange of water across the blood-brain barrier: functional roles of aquaporin water channels. |
| 8.30 - 9.30 | Four: Selected from the day's posters |
| 9.30 - | Posters, further discussion and social occasion |
| TUESDAY |
| 7.30 - 8.30 | Breakfast |
| 9.00-12.30 | Physiology, Pharmacology and Biochemistry of Blood-Brain Barriers |
| Chair and Discussion Leader:
Richard Keep, University of Michigan, USA |
| 09.00 | Chris Higgins, MRC Clinical Sciences Centre, Imperial College London, UK
P-glycoprotein: How does it function? |
| 09.30 | Charles Nicholson, New York University, NY, USA.
The Relevance of ISF Production and Bulk Flow to Brain Drug Transport. |
| 10.00 - 10:30 | Coffee |
| 10.30 | Tom Abbruscato, Texas Tech University, Amarillo, USA
Ion Transporters at the BBB: Altered Function After Nicotine Exposure and Stroke Condition. |
| 11.00 | Ron Sawchuk, University of Minnesota, USA
Microdialysis: A Tool to Measure Brain-Uptake? |
| 11.30 - 12.30 | Poster Session and Coffee
(Presence of poster presenters for Session 3 mandatory) |
| 12.30 | Lunch |
| Afternoon Free for activities and discussion |
| 4:00-6:00 | Optional Workshop/Discussion
Gene Arrays, Proteomics and the BBB
Discussion Leader: Damir Janigro, Cleveland Clinic Foundation, Cleveland, USA |
| 6.00 | Dinner |
| 7.30-9.30 | Physiology, Pharmacology and Biochemistry of Blood-Brain Barriers |
| Chair and Discussion Leader:
Bill Banks, VAMC, University of St. Louis, USA |
| 7.30 | Yuichi Sugiyama, University of Tokyo, Japan
Efflux Transporters in the CNS: Their Role in Drug Distribution. |
| 8.00 | Sarah Thomas, King's College London, UK
Anti-HIV Drug Transport at the Blood-Brain Barrier. |
| 8.30 - 9.30 | Four: Selected from the day's posters |
| 9.30 - | Posters, further discussion and social occasion |
| WEDNESDAY |
| 7.30 - 8.30 | Breakfast |
| 9.00-12.30 | Blood-Brain Barriers and Pathology |
| Chair and Discussion Leader:
Bill Hickey, Dartmouth-Hitchcock Medical Center, USA |
| 09.00 | Britta Engelhardt, Max Planck Institute - Bad Nauheim, Germany
Molecular mechanisms of T lymphocyte interaction with the Blood-Brain Barrier. |
| 09.30 | Wei Zheng, Columbia University, NY, USA
The Blood-Brain Barrier and Heavy Metal Toxicity. |
| 10.00 - 10:30 | Coffee |
| 10.30 | Katerina Dorovini Zis, University of British Columbia, Canada
Multiple Sclerosis and the Blood-Brain Barrier. |
| 11.00 | Ignatio Romero, Open University, UK
Viral entry to the Brain. |
| 11.30 - 12.30 | Poster Session and Coffee
(Presence of poster presenters for Session 4 mandatory) |
| 12.30 | Lunch |
| Afternoon Free for activities and discussion |
| 4:00-6:00 | Optional Workshop/Discussion
Microdialysis Techniques in the CNS
Discussion Leader: Bill Elmquist, College of Pharmacy, University of Nebraska Medical Center, Nebraska, USA |
| 6.00 | Dinner |
| 7.30-9.30 | Blood-Brain Barriers and Pathology |
| Chair and Discussion Leader:
Paula Dore-Duffy, Wayne State School of Medicine, USA |
| 7.30 | Jane Preston, King's College London, UK.
Ageing of the
Blood-CSF Barrier. |
| 8.00-9.00 | Four: Selected from the day's posters |
| 9.00 - 9.30 | Business meeting |
| 9.30 - | Posters, further discussion and social occasion |
| THURSDAY |
| 7.30 - 8.30 | Breakfast |
| 9.00-12.30 | Drug Delivery to the CNS |
| Chair and Discussion Leader:
Ed Neuwalt, Oregon Health Science University, Portland, USA |
| 09.00 | Akira Tsuji, Kanazawa University, Japan
Employing Blood-Brain Barrier Transporters to Deliver Drugs to the Brain. |
| 09.30 | Jean-Michel Scherrmann, INSERM U26, Paris, France
Using Peptide Vectors to Target Drugs to the Brain. |
| 10.00 - 10:30 | Coffee |
| 10.30 | Jörg Huwyler, Hofmann-La Roche, Basel, Switzerland
The use of Liposomes to Target Drugs to the Brain. |
| 11.00 | Jörg Kreuter, University of Frankfurt, Germany
Nanoparticle Systems to Target Drugs to the Brain. |
| 11.00 - 12.30 | Poster Session and Coffee
(Presence of poster presenters for Session 5 mandatory) |
| 12.30 | Lunch |
| Afternoon Free for activities and discussion |
| 4:00-6:00 | Optional Workshop/Discussion
Comparative Evaluation of In Vitro Models of the BBB
Discussion leader: Annette Bartmann, Central Laboratory of German Pharmacists, Eschborn, Germany |
| 6.00 | Dinner |
| 7.30-9.30 | Drug Delivery to the CNS |
| Chair and Discusion Leader:
Tom Davis, University of Arizona, Tucson, USA |
| 7.30 | Sasha Kabanov, University of Nebraska, USA.
Pluronics as CNS Drug Delivery Systems. |
| 8.00 | Alain Minn, University of Nancy, France.
Drug Metabolism in the Brain and Blood-Brain Interfaces. The Implications for Drug Delivery to the Brain. |
| 8.30 - 9.30 | Four: Selected from the day's posters |
| 9.30 - | Posters, further discussion and social occasion |
| FRIDAY |
| 7.30 - 8.30 | Breakfast |
| 9.00 - | Departure |
