SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Presentation: Barrier Modeling |
| Discussion Leader: Quentin Smith (Texas Tech UHSC, Amarillo, TX) |
7:40 pm - 7:50 pm | Welcome |
7:50 pm - 8:25 pm | Tetsuya Terasaki (Tohuko University, Sendai, Japan)
"Blood-Brain Barrier Pharmacoproteomics (PPx): Challenge for the Discovery of New Barrier Function in Humans" |
8:25 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | Damir Janigro (Cleveland Clinic, Cleveland, OH)
"Inflammatory Events Initiate and Result from BBB Failure" |
9:15 pm - 9:30 pm | Discussion
|
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Barrier Structure and Function |
| Discussion Leaders: Richard Keep (University of Michigan, Ann Arbor, MI), Karen Mark (South College, Knoxville, TN) |
9:00 am - 9:20 am | Lester Drewes (University of Minnesota, Duluth, MN)
"Acute Regulation of MCT1 Function in Brain Endothelial Cells by cAMP Dependent Vesicular Trafficking" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Graham K. Farrington (Biogenidec Corporation, Weston, MA)
"Receptor-Mediated Transcytosis: Ins and Outs of the Blood Brain Barrier Transport" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Ulrich Bickel (Texas Tech UHSC, Amarillo, TX)
"T-Cell Receptor Mimics as Novel Tools for Brain Targeting" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Farida Sohrabji (Texas A&M HSC, College Station, TX)
"Age and Sex Differences in the Blood Brain Barrier: Implications for Stroke" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Joseph Nicolazzo (Monash U, Victoria Australia)
"The Impact of Systemic Inflammation and Bacterial Infection on the Blood-Brain Barrier Transport of Colistin"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Discussion Leader Wrap-Up |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Barrier Permeability and Signaling |
| Discussion Leaders: Pierre-Olivier Couraud (INSERM, France), Joan Abbott (Kings College, London, UK) |
7:30 pm - 7:50 pm | Richard Daneman (UCSF Department of Anatomy, San Francisco, CA)
"Molecular Mechanisms of Blood-Brain Barrier Formation" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Stefan Liebner (Goethe University, Frankfurt, Germany)
"Molecular Regulation of Endothelial Barrier Function at the Blood-Brain Barrier" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Weihong Pan (Pennington Biomedical Research Center, Baton Rouge, LA)
"BBB Cytokine Signaling - from Cell Biology to Behavior" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Alex Avdeef (in-ADME Research, Boston, MA)
"Barrier Permeability and Various In Vitro Models for Predicting It" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Barrier Imaging |
| Discussion Leaders: M Waleed Gaber (Baylor University, Houston, TX) and Paul Lockman (Texas Tech UHSC, Amarillo, TX) |
9:00 am - 9:20 am | Tavakere Nagaraja (Henry Ford Health System, Detroit, MI)
"Localization and Quantification of BBB Dysfunction and Implications to Treatments" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Bill Rooney (Oregon HSU, Portland, OR)
"Quantitative MRI of BBB Permeability in Neuroinflammation" |
9:50 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:50 am | Kullervo Hynynen (University of Toronto, Canada)
"MRI-Guided and Monitored Local BBB Disruption by Focused Ultrasound for Targeted Drug Delivery" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Stina Syvänen (University of Leiden, Netherlands)
"The Search for a Reliable PET Tracer for Imaging of P-glycoprotein Function at the Blood-Brain Barrier" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Karunya Kandimalla (University of Minnesota, Minneapolis, MN)
"Traffic Jam at the Blood Brain Barrier Promotes Greater Accumulation of Alzheimer's Disease Amyloid Beta Proteins in the Cerebral Vasculature"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Discussion Leader Wrap-Up |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Other Barrier Systems |
| Discussion Leaders: Hazel Jones (Kings College, London, UK) and Tom Abbruscato (Texas Tech UHSC, Amarillo, TX) |
7:30 pm - 7:50 pm | Robert Thorne (University of Wisconsin, Madison, WI)
"Barriers to Diffusion in the Extracellular Spaces of the Living Brain" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Chris Campos (NIEHS, Research Triangle Park, NC)
"ABC Transporter Function and Regulation at the Blood-Spinal Cord Barrier" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Ken-Ichi Hosoya (University of Toyama, Toyama, Japan)
"The Inner Blood-Retinal Barrier in Retinal Drug Delivery" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Jean-Francois Ghersi-Egea (INSERM, France)
"Neuroprotective Mechanisms Associated With the Blood-CSF Barrier in the Developing Brain" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Barrier Transporters |
| Discussion Leaders: David Miller (NIEHS, Research Triangle Park, NC) and Tom Raub (Lilly Research Labs, Indianapolis, IN) |
9:00 am - 9:20 am | Jean-Michel Scherrmann (INSERM, Paris, France)
"The Ah Receptor as a Target Modulating Drug Metabolism Enzymes and ABC Transporters in hCMEC/D3 Cells" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Elizabeth Hopper-Borge (Fox Chase Cancer Center, Philadelphia, PA)
"Abcc10 (MRP7) as a Breast Cancer Treatment Resistance Factor" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Ian Simpson (Penn State, State College, PA)
"Transport of Glucose Across the BBB Revisited" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Anika Hartz (University of Minnesota, Duluth, MN)
"Blood-Brain Barrier P-glycoprotein: A New Therapeutic Target in Alzheimer's Disease?" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Anne Mahringer (University of Heidelberg, Heidelberg, Germany)
"Interaction between Alpha-Synuclein and P-Glycoprotein at the BBB" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Patrick Ronaldson (University of Arizona, Tucson, AZ)
"Targeting Organic Anion Transporting Polypeptide 1a4 (Oatp1a4) at the Blood-Brain Barrier for Optimization of CNS Drug Delivery" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Drug Delivery |
| Discussion Leaders: Margaretta Hammarlund-Udenaes (Uppsala University, Uppsala, Sweden), David Smith (University of Michigan, Ann Arbor, MI) |
7:30 pm - 7:50 pm | Alexander Kabanov (University of Nebraska, Omaha, NE)
"Nanomedicines for Protein Delivery to the Brain" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Jean Lachowicz (Angiochem, Montreal, Canada)
"Successfully Accessing the Brain using EPiC Technology" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Li Di (Pfizer, Groton, CT)
"Overcoming Blood Brain Barrier Challenges in CNS Drug Discovery" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Maxime Culot (University of Artois, France)
"Assessing the Free Brain/Free Plasma Ratio In Vitro in Early Drug Discovery" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | Barrier Alterations in Disease |
| Discussion Leader: Damir Janigro (Cleveland Clinic, Cleveland, OH) and David Begley (Kings College, London, UK) |
9:00 am - 9:20 am | Tom Davis (University of Arizona, Tucson, AZ)
"P-glycoprotein Trafficking at the BBB altered by Peripheral Inflammatory Pain" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Jim Connor (Penn State, College Station, PA)
"Mechanisms of Iron Uptake into the Brain and their Regulation--a New Concept for the BBB" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Maria A Deli (Hungarian Academy of Sciences, Szeged, Hungary)
"Blood-Brain Barrier in Pancreatitis" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Greg Bix (University of Kentucky, Lexington, KY)
"Enter the Matrix: Perlecan Domain V as a Novel Stroke Therapy" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Reina Bendayan (University of Toronto, Toronto CA)
"In Vivo Model of HIV-1 Associated Neuro-Inflammation: Potential Therapeutic Approaches"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Discussion Leader Wrap-Up |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Brain Tumors |
| Discussion Leader: Gert Fricker (University of Heidelberg, Heidelberg, Germany) |
7:30 pm - 7:50 pm | Bill Elmquist (University of Minnesota, Minneapolis, MN)
"Molecularly-Targeted Therapy for Primary and Metastatic Brain Tumors" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Olaf Van Tellingen (Netherlands Cancer Institute, Amsterdam, NL)
"Chemotherapeutic Drug Delivery for the Treatment of Brain Tumors" |
8:20 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Clinton Stewart (St. Jude Children's Research Hospital)
"CNS Drug Penetration in Murine Models of Pediatric Brain Tumors: Getting Past the Barriers"
|
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | Overall Discussion |
| Quentin Smith and Margaretta Hammarlund-Udenaes |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |