Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Novel Strategies to Overcome Multiple Barriers in the CNS
Discussion Leader: Lester Drewes (University of Minnesota, United States)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
Chenghua Gu (Harvard Medical School, United States)
"Molecular Mechanisms Governing the Blood-CNS Barrier Function"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Tetsuya Terasaki (University of Eastern Finland, Finland)
"Proteotyping of 4 Barriers of the CNS: Consideration of Functional Similarity and Difference"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Experimental Models of Brain Barriers
Discussion Leaders: Samira Azarin (University of Minnesota, United States) and Eric Shusta (University of Wisconsin-Madison, United States)
9:00 am - 9:20 am
Choi-Fong Cho (Brigham and Women's Hospital, United States)
"Organoids as BBB Modeling Platform"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Richard Daneman (UCSD, United States)
"Regulation of BBB by Neural Activity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Ethan Lippmann (Vanderbilt University, United States)
"Engineering 3D Neurovascular Models with Bioinstructive Hydrogels"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Samira Azarin (University of Minnesota, United States)
"In Vitro Models of Blood-Brain Barrier Disruption"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Michael Workman (Cedars-Sinai Medical Center, United States)
"Perfusable Blood-Brain Barrier-on-a-Chip for Modeling Neurological Disease and Drug Delivery"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Natasha O'Brown (Harvard Medical School, United States)
"Interrogating Neurovascular Interactions in the Zebrafish BBB"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Britta Engelhardt (University of Bern, Switzerland)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Changes in BBB Structure and Function in Disease
Discussion Leaders: Reina Bendayan (University of Toronto, Canada) and Francesca Cicchetti (Centre de Recherche du CHU de Québec, Université Laval, Canada)
7:30 pm - 7:50 pm
Bjoern Bauer (University of Kentucky, United States)
"Blood-Brain Barrier Dysfunction and Repair in Epilepsy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Richard Keep (University of Michigan, United States)
"Tales from the Clot: The Effects of Hemorrhagic Stroke on the Blood-Brain Barriers"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Stefan Liebner (University Hospital, Goethe University Frankfurt, Germany)
"Molecular Regulation of Brain Endothelial Barrier Properties in Health and Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Brandon Kim (University of Alabama, United States)
"Estrogen Signaling Contributes to Group B Streptococcal Disruption and Invasion of Brain Endothelial Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Delivery of Macromolecular Therapeutics to the Brain
Discussion Leaders: Danica Stanimirovic (National Research Council / University of Ottawa, Canada) and Michelle Pizzo (Denali Therapeutics, United States)
9:00 am - 9:20 am
Claire O'Connor (Smurfit Institute of Genetics, Trinity College Dublin, Ireland)
"AAV-mediated Regulation of Claudin-5 at the Blood Brain Barrier as a Gene Therapy Based Approach for Neurological Disorders"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Priti Kumar (Yale University, United States)
"Up the Nose and Into the Brain"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 10:50 am
Joelle Straehla (Dana-Farber/Boston Children's Cancer and Blood Disorders Center, United States)
"Nanoparticle Trafficking Across the BBB: In Vitro versus In Vivo"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Joy Zuchero (Denali Therapeutics, United States)
"Enabling CNS Therapeutics with the Transport Vehicle"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Timothy Phoenix (University of Cincinnati, United States)
"Dissecting Tumor-Vascular Interactions That Modulate Blood-Brain Barrier Function"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Steffen Storck (Washington University of St. Louis School of Medicine, United States)
"Recent Advances in Barriers of the CNS Research"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Understudied Barriers of the CNS
Discussion Leaders: Bjoern Bauer (University of Kentucky, United States) and Maria Deli (Biological Research Centre Szeged, Hungary)
7:30 pm - 7:50 pm
Laura Bojarskaite (GliaLab, Letten Center, University of Oslo, Oslo University Hospital, Norway)
"Sleep Cycle-dependent Vascular Dynamics Facilitate Perivascular CSF Flow"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
David Antonetti (University of Michigan, United States)
"Novel Role for Occludin in VEGF-Driven Neovascularization"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Julie Siegenthaler (UNIVERSITY OF COLORADO, ANSCHUTZ MEDICAL CAMPUS, United States)
"Making and Breaking Meninges Barriers: Arachnoid Barrier in Development and Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Luca von Allmen (Biozentrum, University of Basel, Switzerland)
"Sex Differences in the Lateral Ventricle Choroid Plexus"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Methods of Delivery to Overcome Brain Barriers
Discussion Leaders: Nathalie Agar (Harvard Medical School / Dana-Farber Cancer Institute / Brigham and Women's Hospital, United States) and Sadhana Jackson (National Institutes of Health, United States)
9:00 am - 9:20 am
Zhenpeng Qin (University of Texas at Dallas, United States)
"Mechanobiological Modulation of the Blood-Brain Barrier by Laser Stimulation of Vascular Targeted Nanoparticles"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Adrienne Boire (Memorial Sloan Kettering Cancer Center, United States)
"Cancer Cell-Microenvironmental Interactions Support Leptomeningeal Metastasis"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Elisa Konofagou (Columbia University, United States)
"Ultrasound-Mediated Immunomodulation, Drug and Gene Delivery through the Opened Blood-Brain Barrier"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Rachael Sirianni (UMass Chan Medical School, United States)
"Delivering Nanomedicine to Pediatric Brain Tumors: The Intrathecal Route"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Gerry Grant (Duke University, United States)
"Breaking Down the Blood-Tumor Barrier"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Kathryn Blethen (West Virginia University, United States)
"Role of the Immune Response to Whole-Brain Radiation Therapy on Blood-Brain Barrier Integrity"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Roosmarijn Vandenbroucke (VIB, Ghent University, Belgium)
"Helicobactor Pylori-Derived Outer Membrane Vesicles Cross the Brain Barriers and Contribute to Alzheimer’s Disease Pathogenesis via C3-C3aR Signaling"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Influence of Neuroinflammation on the BBB
Discussion Leaders: Joseph Nicolazzo (Monash University, Australia) and Roosmarijn Vandenbroucke (VIB, Ghent University, Belgium)
7:30 pm - 7:50 pm
David Camarillo (Stanford University, United States)
"Biomechanical Disruption of the Blood-Brain Barrier in Mild Trauma"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Anika Hartz (University of Kentucky, United States)
"Blood-Brain Barrier Repair in Alzheimer’s Disease with Epilepsy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Laurence Dion-Albert (CERVO Brain Research Center, Université Laval, Canada)
"Role of Pericytes in Sex-Specific Neurovascular Changes Involved in Stress Responses and Human Depression"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Steffen Storck (Washington University of St. Louis School of Medicine, United States)
"Meningeal Lymphatics are Functionally Linked to the Integrity of the Blood-Brain Barrier"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
CSF and ISF: Fluid Flow and Exchange in the CNS
Discussion Leader: Robert Thorne (Denali Therapeutics / University of Minnesota, United States)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:40 am
Steven Proulx (University of Bern, Switzerland)
"CSF Circulation and Outflow Pathways: New Anatomical Insights on Efflux Along Olfactory Nerves"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
Nanna MacAulay (University of Copenhagen, Denmark)
"Mechanisms of CSF Secretion: We Know So Much, Yet Understand So Little"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Charles Nicholson (New York University School of Medicine, United States)
"Molecular Transport in the Interstitial Component of Extracellular Space: Knowns and Unknowns"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
Mohammad Jafarnejad (Denali Therapeutics, United States)
"Quantitative Systems Pharmacology Modeling of Enzyme Replacement Therapies (ERTs) Reveals Key Brain & CSF PK/PD Relationships"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Max Tischfield (Rutgers University, United States)
"Pressure Effects on the Glymphatic and Meningeal Lymphatic Systems in Craniosynostosis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Fluid Flow in the Brain
Discussion Leaders: Irena Loryan (Uppsala University, Sweden) and Steven Proulx (University of Bern, Switzerland)
7:30 pm - 8:00 pm
Britta Engelhardt (University of Bern, Switzerland)
"The Brain Barriers Establish CNS Immune Privilege"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Laura Lewis (Boston University, United States)
"Cerebrospinal Fluid Flow Across Sleep and Wakefulness"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
General Discussion
9:10 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure