| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Lecture |
| 3:15 pm - 3:45 pm | Joan Abbott (King's College London, UK)
"History of blood-brain-barriers and important methods to study these barriers" |
| 3:45 pm - 4:00 pm | Discussion |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Perfusion/Microdialysis, Imaging techniques |
| Discussion Leaders: Danica Staminirovic (University of Ottawa, Canada) and Elisabeth de Lange (Leiden University, The Netherlands) |
| 7:30 pm - 7:50 pm | Olga Huber (University of Heidelberg)
"Use of single molecule localization microscopy to analyze the expression pattern of P-glycoprotein" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Sripad Ram (University of Texas Southwestern Medical Center)
"Understanding the mechanisms of antibody transport at the blood brain barrier" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Rachita K. Sumbria (Texas Tech University Health Sciences Center)
"Quantitative Estimation of Blood-Brain Barrier Opening Following Ischemia Reperfusion Using Intracerebral Microdialysis" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Li Yang (Texas Tech University, Pharmaceutical Sciences Department)
"Characterization of the Neuroprotective Effects of Biphalin, a Potent Opioid Receptor Agonist, in Focal Brain Ischemia" |
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | In vivo, ex vivo, in vitro models |
| Discussion Leaders: Hans-Joachim Galla (University of Muenster, Germany) and David Miller (NIH/NIEHS, North Carolina, USA) |
| 9:00 am - 9:20 am | Douglas N. Clarke (Texas A&M University Health Science Center)
"Perlecan Domain V enhances brain microvascular endothelial cell angiogenesis by interacting with the integrin a5β1, activating the ERK-(1/2) signaling pathway, and causing the release of VEGF" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Jisook Lee (University of California, San Diego)
"Conditional FAK deletion mediates blood-brain barrier remodeling in glioma" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Sagar Argawal (University of Minnesota)
"P-gp and BCRP 'Co-operate' at the BBB to Limit Brain Penetration of Tyrosine Kinase Inhibitors - Impact on Chemotherapy in Glioma" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Shameena Bake (Texas A&M Health Science Center)
"Sex differences in structural properties of the blood brain barrier and endothelial function: Role of reproductive aging" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Jorge I. Alvarez (University of Montreal)
"The hedgehog pathway sustains blood-brain barrier properties and promotes CNS immune quiescence" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | John C. Peart (Laboratory of Toxicology and Pharmacology, NIH/NIEHS)
"Sphingosine-1-Phosphate (S1P) exposure reduces P-glycoprotein (P-gp) transport activity in rat brain capillaries" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 3:30 pm | Poster Session II |
| 3:30 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
