| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session |
| Discussion Leaders: Christopher Campos (NIH, NIEHS, Research Triangle Park, NC, USA) and Joan N. Abbott (Kings College, London, UK) |
| 3:45 pm - 4:15 pm | David Antonetti (University of Michigan, Ann Arbor, MI, USA)
"Novel Roles for Tight Junction Proteins in Growth, Migration and Barrier Formation"
|
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Function and Regulation of the CNS Barriers |
| Discussion Leaders: Daniel Gonzalez Carter (Imperial College, London, UK) and Maria Brito (University of Lisbon, Lisbon, Portugal) |
| 7:30 pm - 7:50 pm | Roosmarijn Vandenbroucke (Ghent Univeristy, Ghent, Belgium)
"Choroid Plexus Derived Extracellular Vesicles from the Choroid Plexus Mediate Blood-Brain Communication"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Ganesh Bhat (IFOM, Milan, Italy)
"Sox17 Is a Novel Mediator of Wnt/β-Catenin Mediated Blood Brain Barrier Development and Maintenance"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Stefanie Gurnik (Frankfurt University, Frankfurt, Germany)
"Interference of Angiopoietin Signaling with Blood-Brain Barrier Properties"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Mark Bollinger (University of Michigan, Ann Arbor, MI, USA)
"Occludin Ser471 Phosphorylation Contributes to Tight Junction (TJ) Formation and Cell Packing at Confluence"
|
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 9:30 am | Mentorship Lecture |
| Discussion Leaders: Xiang Yi (University of North Carlolina, Chapel Hill,NC, USA) and Robert Thorne (University of Wisconsin, Madison, WI, USA) |
| 9:00 am - 9:20 am | Norman Saunders (University of Melbourne, Australia)
"Misconceptions, Misunderstandings and Mis-Citations in Blood-Brain Barrier Biology"
|
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 11:00 am | Barriers in the CNS Disease |
| Discussion Leaders: Holly Johnson (St. Jude Childrens Research Hospital, Memphis, TN, USA) and Stefan Liebner (University of Frankfurt, Frankfurt, Germany) |
| 9:30 am - 9:50 am | Kim Brandon (Sandiego State University, Sandiego, CA, USA)
"Regulation of Tight Junction Complexes in the Brain Endothelium by Bacterial Meningeal Pathogens"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Ritu Mishra (CCMB, Hyderabad, India)
"HIV-1 Tat Protein Exploits the microRNA Mediated Regulation of Blood Brain Barrier Permeability"
|
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Viorica Braniste (Karolinska Institute, Stockholm, Sweden)
"The Blood-Brain-Barrier Permeability Is Regulated by the Gut Microbiome"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Modeling the CNS Barriers and Drug Delivery Strategies |
| Discussion Leaders: Stefanie Robel (University of Alabama, Birmingham, AL, USA) and William Elmquist (University of Minnesota, Minneapolis, MN, USA) |
| 1:30 pm - 1:50 pm | Abraham Alahmad (Texas Tech University Health Sciences Center, Amarillo, TX, USA)
"Human Induced Pluripotent Stem Cells for Modeling the Blood-Brain Barrier During Health and Diseases"
|
| 1:50 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:20 pm | Urich Eduard (F. Hoffmann-LaRoche, Basel, Switzerland)
"Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle" |
| 2:20 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
