Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Neuroinflammatory Mechanisms of Blood-Brain Barrier Disruption
Discussion Leaders: Helga De Vries (VU University Medical Center, The Netherlands) and Leon Smyth (University of Auckland, New Zealand)
3:45 pm - 4:15 pm
Aaron Johnson (Mayo Clinic, USA)
"CD8 T Cell-Mediated Disruption of the Blood-Brain Barrier in Experimental Models of Human Neurologic Disease"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Brain Barriers: Function and Dysfunction
Discussion Leaders: Michelle Pizzo (University of Wisconsin-Madison, USA) and Ricardo Figueiredo (GenXPro GmbH, Germany)
7:30 pm - 7:50 pm
Azzurra Cottarelli (Columbia University Medical Center, USA)
"Rab7 Regulates Endothelial Tight Junction Protein Trafficking and Paracellular Permeability of the Blood-Brain Barrier After Ischemic Stroke"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Eduardo Frias-Anaya (The Open University, United Kingdom)
"Age-Induced Changes in Gene Expression and Ultrastructure at the Mouse Blood-Brain Barrier"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Emma Neal (Vanderbilt University, USA)
"Role of IQGAP Proteins in Blood-Brain Barrier Biology"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Raoul Freitas Vale Germano (Laboratory of Neurovascular Signaling, Université Libre de Bruxelles, Belgium)
"Definition of the Core Vertebrate Blood Brain Barrier Transcriptome"
9:20 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Efflux, Influx and Delivery Across the Brain Barriers
Discussion Leaders: Markus Schuster (Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland) and Surabhi Talele (University of Minnesota, Twin Cities, USA)
9:00 am - 9:20 am
Steffen Storck (University Medical Center of the Johannes Gutenberg University Mainz, Germany)
"Not Separate but Together: ABCB1/P-gp and LRP1 Mediate a Concerted Clearance of Aβ Across the Blood-Brain Barrier"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Brynna Wilken-Resman (University of Wisconsin-Madison, USA)
"Distribution of Intrathecal Antisense Oligonucleotides in the CNS and Implications for the Treatment of Neurodegenerative Diseases"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Jordan Norwood (Pennsylvania State University, USA)
"Anatomical Basis for Cerebrospinal Fluid and Interstitial Fluid Transport Through the Cribriform Plate in Mice"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
Elena Puris (University of Eastern Finland, Finland)
"L-Type Amino Acid Transporter 1 Utilizing Prodrugs: Promising Approach to Targeted Brain Delivery of CNS-Acting Drugs"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Fundraising from Private and Public Sources
Discussion Leader: Aaron Johnson (Mayo Clinic, USA)
1:30 pm - 2:30 pm
Panel Discussion
Fundraising from Private and Public Sources
N. Joan Abbott (King's College London, United Kingdom)
Noel Derecki (Janssen, USA)
Jessica Plavicki (Brown University, USA)
Stina Syvänen (Uppsala University, Sweden)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes