Opening Session:

• Stanley Roberts (Liverpool, UK) - Enzymic Baeyer Villiger Reaction
• J. John Holbrook (U. Bristol, UK) - Getting the Products Off Enzymes Used in Bulk Chemoenzymic Synthesis

Structure and Engineering of Hydrolases for Organic Synthesis

• Sabine L. Flitsch (U. Edinburgh, UK) - Design and Synthesis of Enzyme-Cleavable Linkers for Solid Phase Synthesis
• Guy G. Dodson (York U., UK) - Nucleophilic Attack at the Carbonyl in Hydrolases: The Varying Stereochemistry at the Nucleophile
• Franz Effenberger (U. Stuttgart, Germany) - New Results on Preparation and Application of Chiral Cyanohydrins
• Robert Menard (NRC Biotechnology Research Institute, Canada) - Protein Engineering of Cysteine Proteases: From a Better Understanding of Their Function to Redesigning the Catalytic Activity

Molecular Evolution of Proteases and Esterases

• Frances Arnold (California Institute of Technology, USA) - Directed Evolution of a p-Nitrobenzyl Esterase
• Marcus Ballinger (Genentech, USA) - Subtilisin BPN Variants Designed for Cleavage of Multibasic Substrates
• Volker Schellenberger (Genencor, USA) - Directed evolution of a Bacillus protease

New Application of Hydrolases

• Herbert Waldmann (Karlsruhe, Germany) - Bioorganic Synthesis and Biological Signal Transduction
• Milton Zmijewski (Lily, Indianapolis, USA) - Enzymatic Removal of Protecting Groups in the Synthesis of Pharmaceuticals
• Kazuo Achiwa (Shizuoka U.) - Lipase-Catalyzes AsymmetricSynthesis of Optically-Active Medicines: New Strategies and their Application

Discovery versus Engineering of New Enzymes

• John Arnett (Recombinant Biocatalysis, USA) - Enzymes from Thermophilic Microorganisms
• Gunter Schneider (Karolinska Institute, Stockholm, Sweden) - Toward Tailoring Enzymes for Asymmetric Synthesis: Protein Engineering of Transketolase

Aldolases and Glycosyl Transfer

• Eric Toone (Duke University) - Pyruvate Aldolases
• Vladimir Kren (Czech Academy of Sciences) - Enzymatic Glycosylation of Pharmacologically Active Compounds: Multienzymatic Approaches and New Enzymes

New Hydrolases

• Roland Furstoss (U. Aix-Marseille, France) - Enantioselective Biotransformations with Epoxide Hydrolases
• Kenji Soda (Kyoto, Japan) - 2-Haloacid Dehalogenases: Their Functions, Structures, and Applications

Oxidations

• Aleksey Zaks (Schering-Plough, Union, NJ, USA) - Chloroperoxidase
• Bernhard Hauer (BASF AG, Ludwigshafen, Germany) - Selection of Biocatalysts for the Preparation of Chiral/Chemical Building Blocks
• Roger Sheldon (Delft U. Netherlands) Enantioselective Aminolysis and Selective Oxidations Mediated by Chloroperoxidase

Large Scale Industrial Applications

• Kevin DiGregorio (Union Carbide, USA) - Polyester Hydrolysis
• Robert Dicosimo (Dupont, Wilmington, DE, USA) - Scale-Up of a Biocatalytic Route to N-Phosphonomethylglycine (Glyphosate) Using Whole Cell Transformants