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Biocatalysis

Gordon Research Conference

July 5 - 10, 1998
Chairs David R. Dodds and Tomas Hudlicky
Vice Chairs Monica M. Palcic and Milton J. Zmijewski

Conference Program

Sunday evening, July 5 Discussion Leader: Bryan Jones, University of Toronto

7:15 p.m. opening remarks
7:30 p.m. Carl Johnson,
Wayne State University		 "Chemoenzymatic Synthesis Of Bioactive Targets From Commodity Chemicals"
8:30 p.m. Jack Rosazza,
University of Iowa		 "Biocatalysis from the Heartland: Bioconversions of Natural Antioxidants"

Monday morning, July 6 Discussion Leader: Herbert Holland, Brock University

9:00 a.m. Derek Boyd,
Queen's University, Belfast		 "Dioxygenase-Catalysed Asymmetric Oxidations: A Comparative Study"
10-10:30 coffee break and conference photograph
10:30 a.m. John Frost,
Michigan State University		 "Hydroaromatics: Chiral Synthons or Aromatic Precursors?"
11:30 a.m. Chris Willis,
University of Bristol		 "Oxidoreductases in Natural Product Synthesis"
4-6 p.m. First Poster Session

Monday evening, July 6 Discussion Leader: Monica Palcic, University of Alberta

7:30 p.m. Giacomo Carrea,
Istituto di Biocatalisi e Riconoscimento Molecolare, CNR		 "Enantioselective Oxidation of Organic Sulfur Compounds Catalyzed by Cyclohexanone Mono-oxygenase"
8:30 p.m. Jon Stewart,
University of Florida		 "Tailoring Baker's Yeast For Asymmetric Organic Synthesis"

Tuesday morning, July 7 Discussion Leader: David J. Leak, Imperial College of Science, Technology and Medicine, London

9:00 a.m. Christian Wandrey,
Forschunszentrum Jülich		 "Enzyme Reaction Engineering for the Production of Pharmaceutically Relevant Sugars"
10-10:30 coffee break
10:30 a.m. George Wang,
Wayne State University		 "Chemo-enzymatic Synthesis Of Glycoconjugates; From Simple Disaccharides To Carbohydrate Polymers"
11:30 a.m. Agustín López-Munguía,
Instituto de Biotecnología, Universidad Nacional Autónoma de México		 "Traditional And New Applications Of Bacterial And Fungal a-Amylases"
4-6 p.m. First Poster Session (cont'd)

Tuesday evening, July 7 Discussion Leader: Margaret Kayser, University of New Brunswick, Saint John

7:30 p.m. Hiromichi Ohta,
Keio University		 "Biocatalytic asymmetric conversion of Malonate-type Compounds"
8:30 p.m. Roberto Spagnoli,
Hoechst Marion Roussel		 "Industrial Access to Steroids: Changing Paradigms - Novel Challenges"

Wednesday morning, July 8 Discussion Leader: Jan de Bont, Wagenigen Agricultural University

9:00 a.m. Yasuhisa Asano,
Toyama Prefectural University		 "Screening For New Microbial Enzymes And Their Application"
10-10:30 coffee break
10:30 a.m. Toby Richardson,
Diversa		 "Novel Enzymes from Biodiversity"
11:30 a.m. Douglas Ribbons,
Technical University Graz		 "Monitoring Enzymic And Bacterial Culture Biotransformations By Proton-Nmr In Situ"
4-6 p.m. Second Poster Session

Wednesday evening, July 8 Discussion Leader: Jon Stewart, University of Florida

7:30 p.m. ORAL POSTER PRESENTATIONS
  1. Tadashi Ema, Okayama University - "Origin of the Enantioselectivity of Lipases"
  2. Benjamin G. Davis, University of Toronto - "Site-specific Modification of Mutants of Subtilisin Bacillus lentus"
  3. Lana E. Janes, McGill University - "High-throughput Screening of Hydrolase Libraries for Activity and Enantioselectivity"
8:30 p.m. Ramesh N. Patel,
Bristol-Myers Squibb Pharmaceutical Research Institute		 "Biocatalytic Syntheses of Chiral Intermediates for Antihypertensive Drugs"

Thursday morning, July 9 Discussion Leader: David Dodds

9:00 a.m. Gary W. Ashley,
KOSAN BioSciences		 "Engineered Polyketide Biosynthesis"
10-10:30 coffee break
10:30 a.m. Neil Bruce,
University of Cambridge		 "Engineering Biocatalytic Routes To Novel Opiate Drugs"
11:30 a.m. Jeremy Minshull,
Maxygen		 "Molecular Evolution of Enzymes and Metabolic Pathways by DNA Shuffling"
4-6 p.m. Second Poster Session (cont'd)

Thursday evening, July 9 Session Chair: Byron Rubin

7:30 p.m. conference elections
8:00 p.m. Gregory A. Petsko,
Brandeis University		 "Enzyme reactions in four dimensions: time-resolved structures of intermediates in the cytochrome P450 and alkaline phosphatase reaction pathways"
9:15 p.m. Closing remarks
9:30 p.m. Multi-media slide show: "The American Scene"

Contributors

Altus Biologics, Inc.
Amano Enzyme USA Co. Ltd.
Bristol-Myers Squibb Pharmaceutical Research Institute
Dow Chemical Co.
E.I. DuPont de Nemours
Eli Lilly & Co.
Elsevier Science, B.V.
Genencor International
Kaneka Corporation
Lonza
Mitsubishi Chemical Co.
MDS Panlabs
Merck & Co.
Pfizer, Inc.
Röhm, GmbH
Schering-Plough Research Institute
Zeneca LifeScience Molecules

Conference Links

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