SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | New Tools for Enzyme Evolution |
| Discussion Leader: Alex Zaks (Schering-Plough Research Institute, US) |
7:35 pm - 8:00 pm | Alexander M. Cruickshank Lecture: Frances Arnold (Caltech, US) "Engineering by Evolution" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Burckhard Seelig (Harvard Medical School, US) "In Vitro Selection and Evolution of De Novo Enzymes" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | David Weiner (Verenium Corporation, US) "Looking to Nature to Make Nature Better: Enzyme Discovery and Evolution for the Development of Green Processes" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Biocatalyst Discovery and Application |
| Discussion Leader: Manfred Schneider (University of Wuppertal, DE) |
9:00 am - 9:30 am | Adam Nelson (University of Leeds, UK) "Evolving Aldolases as Catalysts for Synthetic Chemistry" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Andreas Vogel (c-LEcta GmbH, DE) "Use of Cluster-Screening for the Identification of New, Customized Enzymes in Natural and Artificial Diversity" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Stefan Lutz (Emory University, US) "Engineering Enzymes - New Tricks for Tailoring a Biocatalyst’s Selectivity and Specificity" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Michael Thomas (University of Wisconsin-Madison, US) "Mining the Metagenome for Antibiotic Biosynthetic and Resistance Mechanisms" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Redox Biocatalysis |
| Discussion Leader: Bernhard Hauer (BASF AG, DE) |
7:30 pm - 8:00 pm | Kurt Faber (University of Graz, AT) "Stereo-complementary C=C-Bond Reduction Using Enoate-Reductases" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Jon Stewart (University of Florida, US) "Discovery and Application of Enzymes for Asymmetric Alkene Reductions" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Jan-E Bäckvall (Stockholm University, SE) "Extending the Scope of Asymmetric Transformations in Combined Enzyme and Metal Catalysis" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New Chemistry |
| Discussion Leader: Nick Turner (University of Manchester, UK) |
9:00 am - 9:30 am | Karen Holt-Tiffin (Dowpharma, UK) "Screening Strategies for the Successful Identification of Biocatalysts" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Robert Speight (Ingenza, UK) "Mutagenesis, Screening and Validation of New D-Amino Acid Oxidase Variants for the Manufacture of Unnatural L-Amino Acids" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Hiromichi Ohta (Keio University, JP) "Preparation of Carboxylic Acids Utilizing the Characteristics of Biocatalysis - Oxidation, Hydrolysis, and Decarboxylation" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Bettina Rosche (University of New South Wales, AUS) "Biofilm Factories - Microbial Biofilms for the Production of Chemicals" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Development of Bioprocesses |
| Discussion Leader: Jeff Moore (Merck, US) |
7:30 pm - 8:00 pm | Christian Wandrey (Research Centre Jülich, DE) "Biocatalysis with Designer Bugs for the Production of Chiral Alcohols" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Anke Krebber (Codexis, US) "Combining Statistical Methods with DNA Shuffling for Industrial Biocatalyst Evolution: Case Studies" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Philippe Soucaille (METabolic EXplorer, FR) "In Vivo Evolution of Metabolic Pathways for the Production of Chemicals" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Pathway Engineering |
| Discussion Leader: Andreas Liese (TU Hamburg, DE) |
9:00 am - 9:30 am | John Frost (Michigan State University, US) "Benzene-free, Renewable-based Manufacture of Aromatics" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Michihiko Kataoka (Kyoto University, JP) "Screening of Novel Microbial Enzymes and their Applications to the Large-scale Production of Useful Chemicals" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Chaitan Khosla (Stanford University, US) "Engineered Biosynthesis of Polyketide Antibiotics" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Huimin Zhao (University of Illinois, US) "Enzymatic and Microbial Synthesis of Xylitol from Renewable Biomass" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Bio-oxidation |
| Discussion Leader: Robert Lortie (Biotechnology Research Institute, CAN) |
7:30 pm - 8:00 pm | Sergio Riva (CNR Milano, IT) "Laccase Catalyzed Oxidation of Natural Compounds" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Vlada Urlacher (University of Stuttgart, DE) "Biocatalysis with Cytochrome P450 Monooxygenases: Advantages and Bottlenecks" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Marco Mihovilovic (Vienna University of Technology, AT) "Baeyer-Villiger Monooxygenases in Asymmetric Synthesis and Beyond" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Future Trends |
| Discussion Leader: Uwe Bornscheuer (University of Greifswald, DE) |
9:00 am - 9:30 am | Jens Buchardt (Novo Nordisk, DK) "Enzymatic Methods for the Selective Modification of Therapeutic Proteins" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Ryan Mehl (Franklin & Marshall College, US) "High Yield Genetic Incorporation of Unnatural Amino Acids for Probing Protein Interactions and Dynamics" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Hans-Peter Meyer (Lonza AG, CH) "From Science to Market - Considerations and Perspectives for Biotransformations" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Michael Flickinger (North Carolina State University, US) "Microbial Biocatalysis in Nanoporous Adhesive Coatings" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Future Trends |
| Discussion Leader: Oliver May (DSM, NL) |
7:30 pm - 8:00 pm | Paul Devine (Merck, US) "The Future of Biocatalysis in Big Pharma: Target ID through Process Development" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 9:10 pm | Selected Poster Presentations |
9:10 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |