Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
 
 
						 
						 
					
						
						
7:40 pm - 9:30 pm 
	
Keynote Session: Creating New Activities for Chemical Applications 
 
 
 
						 
						 
					
						
						
7:40 pm - 7:45 pm 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
7:45 pm - 8:20 pm 
	
"Design and Evolution of Artificial Metalloenzymes" 
 
 
 
						 
						 
					
						
						
8:20 pm - 8:35 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:35 pm - 8:40 pm 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
8:40 pm - 9:15 pm 
	
"The Directed Evolution of Biocatalysis" 
 
 
 
						 
						 
					
						
						
9:15 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Expanding the Biocatalytic Toolbox with New Enzymes and New Functions 
 
 
 
						 
						 
					
						
						
9:00 am - 9:30 am 
	
"New Enzymes and Chemistry in Plant Natural Product Pathways" 
 
 
 
						 
						 
					
						
						
9:30 am - 9:45 am 
	
Discussion
 
 
						 
						 
					
						
						
9:45 am - 10:15 am 
	
"Directed Evolution of an Amide Bond-Forming Enzyme in Organic Solvent" 
 
 
 
						 
						 
					
						
						
10:15 am - 10:30 am 
	
Discussion
 
 
						 
						 
					
						
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						 
						 
					
						
						
11:00 am - 11:30 am 
	
"New Biosynthetic Enzymes from Pathogenic Pseudomonas" 
 
 
 
						 
						 
					
						
						
11:30 am - 11:45 am 
	
Discussion
 
 
						 
						 
					
						
						
11:45 am - 12:15 pm 
	
"Biocatalytic Synthesis of Nucleoside and Nucleotide Therapeutics" 
 
 
 
						 
						 
					
						
						
12:15 pm - 12:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
3:00 pm - 4:00 pm 
	
The GRC Power Hourâ„¢ 
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. 
 
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Mechanistic Understanding and Innovative Development Strategies to Enable New Applications 
 
 
 
						 
						 
					
						
						
7:30 pm - 8:00 pm 
	
"Pre-organization & Evolution of Enzyme Active Sites Using the Vibrational Stark Effect" 
 
 
 
						 
						 
					
						
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:10 pm - 8:40 pm 
	
"Accelerating Discovery of Substrate Promiscuity in Cytochrome P450 BM3" 
 
 
 
						 
						 
					
						
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:50 pm - 9:20 pm 
	
"New-to-Nature Metalloredox Biocatalysis for Stereoselective Radical Transformations" 
 
 
 
						 
						 
					
						
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
From Big Data to Enzyme Function via Computational and Bioinformatic Enzyme Design 
 
 
 
						 
						 
					
						
						
9:00 am - 9:30 am 
	
"The Evolutionary Design of Proteins" 
 
 
 
						 
						 
					
						
						
9:30 am - 9:45 am 
	
Discussion
 
 
						 
						 
					
						
						
9:45 am - 10:15 am 
	
"Computational Enzyme Design" 
 
 
 
						 
						 
					
						
						
10:15 am - 10:30 am 
	
Discussion
 
 
						 
						 
					
						
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						 
						 
					
						
						
11:00 am - 11:30 am 
	
"Machine Learning-Guided Enzyme Engineering for Process Chemistry" 
 
 
 
						 
						 
					
						
						
11:30 am - 11:45 am 
	
Discussion
 
 
						 
						 
					
						
						
11:45 am - 12:15 pm 
	
"Improving Imine Reductase by (Machine) Directed Evolution" 
 
 
 
						 
						 
					
						
						
12:15 pm - 12:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Genome Editing and Genetic Code Expansion to Create New Functions 
 
 
 
						 
						 
					
						
						
7:30 pm - 8:00 pm 
	
"Design and Evolution of Enzymes with Non-Canonical Catalytic Mechanisms" 
 
 
 
						 
						 
					
						
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:10 pm - 8:40 pm 
	
"Using a Minimal Bacterial Cell to Investigate the First Principles of Cellular Life" 
 
 
 
						 
						 
					
						
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:50 pm - 9:20 pm 
	
"Synthetic Genetic Systems for Rapid Mutation and Continuous Evolution In Vivo " 
 
 
 
						 
						 
					
						
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
 
 
						 
						 
					
						
						
9:00 am - 9:30 am 
	
"Radical Biocatalysis: Using Light to Reveal New Enzyme Functions" 
 
 
 
						 
						 
					
						
						
9:30 am - 9:45 am 
	
Discussion
 
 
						 
						 
					
						
						
9:45 am - 10:15 am 
	
"Directed Evolution of Nonheme Iron Enzymes to Access Abiological Radical Reactions" 
 
 
 
						 
						 
					
						
						
10:15 am - 10:30 am 
	
Discussion
 
 
						 
						 
					
						
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						 
						 
					
						
						
11:00 am - 11:30 am 
	
"Discovering and Applying New Metalloenzyme-Catalyzed Transformations" 
 
 
 
						 
						 
					
						
						
11:30 am - 11:45 am 
	
Discussion
 
 
						 
						 
					
						
						
11:45 am - 12:15 pm 
	
"Enzymatic Bioelectrocatalysis: From Mechanistic Studies to Bioelectronics and Electrosynthesis Applications" 
 
 
 
						 
						 
					
						
						
12:15 pm - 12:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:00 pm - 7:30 pm 
	
Business Meeting 
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s) 
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Artificial Metalloenzymes 
 
 
 
						 
						 
					
						
						
7:30 pm - 7:50 pm 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
7:50 pm - 8:20 pm 
	
"Designer Enzymes Featuring Unnatural Catalytic Functionalities" 
 
 
 
						 
						 
					
						
						
8:20 pm - 8:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:30 pm - 9:00 pm 
	
"Designing Artificial Metalloenzymes with Activities that Rival Native Enzymes" 
 
 
 
						 
						 
					
						
						
9:00 pm - 9:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:10 pm - 9:30 pm 
	
General Discussion
 
 
						 
						 
					
						
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Natural Product Biosynthetic Enzymes 
 
 
 
						 
						 
					
						
						
9:00 am - 9:30 am 
	
"Engineering Biology at Ginkgo Bioworks: Challenging the Norm" 
 
 
 
						 
						 
					
						
						
9:30 am - 9:45 am 
	
Discussion
 
 
						 
						 
					
						
						
9:45 am - 10:15 am 
	
"Mechanistic Studies of the Stereochemically Controlled Biosynthesis of Fungal Natural Products" 
 
 
 
						 
						 
					
						
						
10:15 am - 10:30 am 
	
Discussion
 
 
						 
						 
					
						
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						 
						 
					
						
						
11:00 am - 11:30 am 
	
"Engineered Biosynthesis of Stereochemically-Complex Amino Acids" 
 
 
 
						 
						 
					
						
						
11:30 am - 11:45 am 
	
Discussion
 
 
						 
						 
					
						
						
11:45 am - 12:15 pm 
	
"Site-Selective Functionalization of Native Proteins Using Engineered Enzymes" 
 
 
 
						 
						 
					
						
						
12:15 pm - 12:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Selected Poster Presentations 
 
 
 
						 
						 
					
						
						
7:30 pm - 7:45 pm 
	
"Biosensor-Based Metabolite Detection and Programming of Microbial Cell Factories" 
 
 
 
						 
						 
					
						
						
7:45 pm - 7:55 pm 
	
Discussion
 
 
						 
						 
					
						
						
7:55 pm - 8:10 pm 
	
"Enhancing the Thermostability of Glucose 6 Oxidase by Combining Directed Evolution and Computational Approaches for its Application in Biosensors" 
 
 
 
						 
						 
					
						
						
8:10 pm - 8:20 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:20 pm - 8:35 pm 
	
"A Biocatalytic Platform for the Synthesis of Nucleic Acid Therapeutics" 
 
 
 
						 
						 
					
						
						
8:35 pm - 8:45 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:45 pm - 9:00 pm 
	
"Nature Inspired Engineering of an Artificial Ligase Enzyme by Domain Fusion" 
 
 
 
						 
						 
					
						
						
9:00 pm - 9:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:10 pm - 9:25 pm 
	
"Accessing Nature's Terpenome via Biocatalytic Shape-Complementary Cationic Cyclization Cascades" 
 
 
 
						 
						 
					
						
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am 
	
Departure