Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Creating New Activities for Chemical Applications
Discussion Leader: Stefan Lutz (Codexis Inc., United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:20 pm
Donald Hilvert (ETH Zurich, Switzerland)
"Design and Evolution of Artificial Metalloenzymes"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 8:40 pm
Introduction by Discussion Leader
8:40 pm - 9:15 pm
Jeffrey Moore (Merck & Co., United States)
"The Directed Evolution of Biocatalysis"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Expanding the Biocatalytic Toolbox with New Enzymes and New Functions
Discussion Leader: Mélanie Hall (University of Graz, Austria)
9:00 am - 9:30 am
Elizabeth Sattely (Stanford University, United States)
"New Enzymes and Chemistry in Plant Natural Product Pathways"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Brent Dorr (GSK, United States)
"Directed Evolution of an Amide Bond-Forming Enzyme in Organic Solvent"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Bo Li (University of North Carolina at Chapel Hill, United States)
"New Biosynthetic Enzymes from Pathogenic Pseudomonas"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
John McIntosh (Merck & Co., United States)
"Biocatalytic Synthesis of Nucleoside and Nucleotide Therapeutics"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Sabine Flitsch (University of Manchester, United Kingdom) and Caroline Paul (Delft University of Technology, The Netherlands)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanistic Understanding and Innovative Development Strategies to Enable New Applications
Discussion Leader: John Woodley (Technical University of Denmark, Denmark)
7:30 pm - 8:00 pm
Steven Boxer (Stanford University, United States)
"Pre-organization & Evolution of Enzyme Active Sites Using the Vibrational Stark Effect"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Joelle Pelletier (Universite de Montreal, Canada)
"Accelerating Discovery of Substrate Promiscuity in Cytochrome P450 BM3"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Yang Yang (University of California Santa Barbara, United States)
"New-to-Nature Metalloredox Biocatalysis for Stereoselective Radical Transformations"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
From Big Data to Enzyme Function via Computational and Bioinformatic Enzyme Design
Discussion Leader: Joelle Pelletier (Universite de Montreal, Canada)
9:00 am - 9:30 am
Rama Ranganathan (University of Chicago, United States)
"The Evolutionary Design of Proteins"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Daniela Grabs (Arzeda Corporation, United States)
"Computational Enzyme Design"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Russell Lewis (Pfizer Worldwide Research and Development, United States)
"Machine Learning-Guided Enzyme Engineering for Process Chemistry"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Radka Snajdrova (Novartis Pharma AG, Switzerland)
"Improving Imine Reductase by (Machine) Directed Evolution"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genome Editing and Genetic Code Expansion to Create New Functions
Discussion Leader: Xue Sherry Gao (Rice University, United States)
7:30 pm - 8:00 pm
Anthony Green (University of Manchester, United Kingdom)
"Design and Evolution of Enzymes with Non-Canonical Catalytic Mechanisms"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
John Glass (J. Craig Venter Institute, United States)
"Using a Minimal Bacterial Cell to Investigate the First Principles of Cellular Life"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Chang Liu (University of California, Irvine, United States)
"Synthetic Genetic Systems for Rapid Mutation and Continuous Evolution In Vivo "
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Radical Biocatalysis
Discussion Leader: Caroline Paul (Delft University of Technology, The Netherlands)
9:00 am - 9:30 am
Todd Hyster (Cornell University, United States)
"Radical Biocatalysis: Using Light to Reveal New Enzyme Functions"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Xiongyi Huang (Johns Hopkins University, United States)
"Directed Evolution of Nonheme Iron Enzymes to Access Abiological Radical Reactions"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Mohammad Seyedsayamdost (Princeton University, United States)
"Discovering and Applying New Metalloenzyme-Catalyzed Transformations"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Shelley Minteer (University of Utah, United States)
"Enzymatic Bioelectrocatalysis: From Mechanistic Studies to Bioelectronics and Electrosynthesis Applications"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Artificial Metalloenzymes
Discussion Leader: Todd Hyster (Cornell University, United States)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
Gerard Roelfes (University of Groningen, The Netherlands)
"Designer Enzymes Featuring Unnatural Catalytic Functionalities"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
Yi Lu (University of Texas at Austin, United States)
"Designing Artificial Metalloenzymes with Activities that Rival Native Enzymes"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Natural Product Biosynthetic Enzymes
Discussion Leader: Claudia Schmidt-Dannert (University of Minnesota, United States)
9:00 am - 9:30 am
Sneha Srikrishnan (Ginkgo Bioworks, United States)
"Engineering Biology at Ginkgo Bioworks: Challenging the Norm"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Xue Sherry Gao (Rice University, United States)
"Mechanistic Studies of the Stereochemically Controlled Biosynthesis of Fungal Natural Products"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Andrew Buller (University of Wisconsin-Madison, United States)
"Engineered Biosynthesis of Stereochemically-Complex Amino Acids"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Anna Fryszkowska (Merck & Co., Inc., United States)
"Site-Selective Functionalization of Native Proteins Using Engineered Enzymes"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Selected Poster Presentations
Discussion Leaders: Carlos Martinez (Pfizer Inc, United States) and Sabine Flitsch (University of Manchester, United Kingdom)
7:30 pm - 7:45 pm
Thomas Bayer (University of Greifswald, Germany)
"Biosensor-Based Metabolite Detection and Programming of Microbial Cell Factories"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Merve Keser (Eyown Technologies S.L, Spain)
"Enhancing the Thermostability of Glucose 6 Oxidase by Combining Directed Evolution and Computational Approaches for its Application in Biosensors"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Ewan Moody (University of Manchester, United Kingdom)
"A Biocatalytic Platform for the Synthesis of Nucleic Acid Therapeutics"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Cher Ling Tong (University of Minnesota - Twin Cities, United States)
"Nature Inspired Engineering of an Artificial Ligase Enzyme by Domain Fusion"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Andreas Schneider (University of Stuttgart, Germany)
"Accessing Nature's Terpenome via Biocatalytic Shape-Complementary Cationic Cyclization Cascades"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure