Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: One Carbon Feedstocks for Biocatalysis
7:40 pm - 8:15 pm
"Re-Inventing the Operating System of Photosynthesis: Building Complex Molecules Out of Thin Air"
8:15 pm - 8:35 pm
Discussion
8:35 pm - 9:10 pm
"New Pathways for Commodity Chemical Synthesis from Methane and Carbon Dioxide"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Improved Enzymes Through In-silico Enzyme Design and Engineering
9:00 am - 9:25 am
"Computationally Designing Enzymes with Nature-Like Catalytic Efficiencies"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Enzyme Design with Generative AI Models"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Automating Computational Enzyme Design in the Quantum Age"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Building 3D-Assembled, Macro-Scale Protein Materials for Enzyme Immobilization and Biocatalysis"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Applications of Biocatalysis with Natural Substrates
7:30 pm - 7:55 pm
"Biocatalytic Approaches to Nucleic Acid Therapeutics Manufacturing"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Process Intensification for Biocatalytic Reactions: Transitioning from Proof-of-Concepts to Technical Scales"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Biocatalysis and Complex Molecule Synthesis"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New to Nature Biocatalysis
9:00 am - 9:25 am
"Endowing Organometallic Catalysts with a Genetic Memory: Artificial Metalloenzymes"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"De Novo Lanthanide Enzymes: From Protein Dynamics to Photoredox Catalysis"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"New Strategies for Stereoselective Radical Biocatalysis"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Design and Engineering of Metalloenzymes for New-to-Nature Reactions"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sustainable Chemistry Through Biocatalysis
7:30 pm - 7:55 pm
"Multi Enzyme Catalysed Processes: From Regulation to Combinations with Microbial Cell Factories and Chemical Synthesis Steps"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Engineering New Enzymes and Cascade Biotransformations for Enantioselective Syntheses of High-Value Chemicals from Simple Substrates"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Biocatalysis for Renewables Utilization"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Reactions in Biocatalysis
9:00 am - 9:25 am
"Enzymatic Construction of DNA-Encoded Chemical Libraries"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Identifying and Engineering New Platform Enzymes for Selective Biocatalysis"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Integrated (Bio)Catalysis: Combining Strategies in Sustainable Synthesis"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Enzymes to Upgrade Rather than Degrade Underused and Renewable Biomass"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Enzymes and Enzyme Engineering
7:30 pm - 7:55 pm
"Mechanoenzymatic Reactions and Other Adventures"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Unlocking Biocatalytic Reactions through Cofactor Tuning"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Genome Mining for New Macrocyclase Biocatalysts"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:15 am
"The Value of Collaboration in Biocatalytic Drug Discovery"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
"Oligonucleotide Manufacturing Using Engineered Enzymes"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
"Reimagine Enzymes: Blending Physics with Generative AI"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:00 am
"Industrial Biocatalysis: Performance Indicators for Quick Cost Estimates"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Engineered (S)-Transaminase Applied in an Organic Solvent"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Rapid Enzyme, Pathway, and Genome Scale Engineering for Whole-Cell Biocatalysis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Early Biocatalysis Strategies with the End in Mind"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanistic Understanding in Biocatalytic Systems
7:30 pm - 7:55 pm
"Repurposing Enzymes for Non-Natural Reactions"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Synthesis of Amide Pharmaceuticals Using Amide Bond Synthetases"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Beyond Nature: Enzymes for Challenging Applications"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure