January 22, 1998 (Thursday)

Joint Program with Metals in Biology

7:30 pm Ken Karlin Comments

7:45 pm Joan Valentine Searching for the Link Between Cu-Zn Superoxide Dismutase and ALS.

8:45 pm Metals in Biology and GRSBI Poster Session I

January 23, 1998 (Friday)

8:30 am Group picture and introductory remarks

9:00 am Brian Hoffman Opening Lecture

Session 1: Protein Electron Transfer

9:30 am Pernilla Wittung-Stafshede (Caltech) Effects of Folding on the Metal Sites of Blue and Purple Copper Proteins.

10:00 am Jonathan Wilker (Caltech) Electron Transfer Through Protein Substrates to Generate Oxidized Hemes in Cytochrome P450-CAM.

10:30 am Charles Wang (Princeton) Models for Nitric Oxide Synthase.

11:00 am Break

11:15 am Mark F. Reynolds (Univ.of Wisconsin) Spectroscopic Studies of the Heme Environment in CO-Sensing CooA.

11:45 am William N. Lanzilotta (Utah State) Coupled Electron and Proton Transfer in the [8Fe-7S] Cluster of Nitrogenase.

12:15 pm Matthew J. Ryle (Utah State) Nucleotide Signal Transduction and Redox Potential Modulation in Nitrogenase.

Session II: Non-Heme Iron Proteins

7:30 pm Eckard Munck Comments

7:45 pm Sun Jae Yoo (Carnegie Mellon) Spectroscopic Evidence for an all Ferrous [4Fe-4S]O Cluster of the Fe-Protein of Nitrogenase.

8:15 pm Hayley C. Angove (UC Irvine) Further Characterization of an All Ferrous State of the Fe Protein of Nitrogenase: Nucleotide Interactions and Electron Transfer to the MoFe Protein.

8:45 pm Natasha Mitic (Yale) MCD and EPR Studies of the Active Site of Phenylalanine Hydroxylase.

9:15 pm Tara Acharya (Yale) Investigation of a Phenylketonuria-Causing Mutant of Phenylalanine Hydroxylase.

10:00 pm Poster Session H (A-K)

January 24, 1998 (Saturday)

Session Ill. Peroxidase to Phosphatase

8:30 am Rick Holz Comments

8:45 am Scott Gordon-Wylie (Carnegie Mellon) Iron and Manganese-Based Complexes that Activate t-Butyl Hydroperoxide and Hydrogen Peroxide.

9:15 am Wieger Hernrika (EC Slater Inst.) From Phosphatases to Vanadium Peroxidases: a Similar Architecture of the Active Site.

9:45 am Maarten Merkx (EC Slater Inst.) Site-Specific Metal Substitutions in the Binuclear Iron Enzyme Purple Acid Phosphatase: Towards the Understanding of the Role of the Fe(Ill)-M(Il)-Core in the Hydrolysis of Phosphate Esters.

10:15 am Break

Session IV. Spectroscopic Characterization of Metalloprotein Active Sites

10:30 am David Briff Comments

10:45 am Jingyuan Ai (Oregon Grad. Inst.) Generation of Stable Mixed-Valence Species in Hemerythrin by Aromatic Substitution.

11:15 am Brian Bennett (Utah State) Structural and Mechanistic Information on Dinuclear Metalloaminopeptidases from EPR.

11:45 am Amy Rocklin (Univ. of Minnesota) Spectroscopic Study of the Ferrous Active Site of 1 -Aminocyclopropane 1 -CarboxyUC Acid Oxidase.

12:15 pm Roehl Cinco (UC Berkeley) Determination of the Structure and Role of the Calcium Cofactor in Oxygen-Evolving Photosystem 11 Using Stronium as a Substitute.

Session V. Inorganic Probes of Nucleic Acids

7:30 pm Steve Lippard Comments

7:45 pm Karen Sandman (MIT) Mechanism-Based Approaches to Detecting Platinum Antitumor Activity.

8:15 pm Sonya J. Franklin (Caltech) DNA Recognition by Shape Selection and Direct Readout: Solution Study of 1 -Rh(MGP)2phi Enantiomers.

8:45 pm Elizabeth Krider (Caltech) Electron Transfer in DNA: Covalent Attachment of Unique Donor and Acceptor Complexes.

9:15 pm Shana O. Kelley (Caltech) Investigations of Long-Range Electron Transfer and Detection of Single-Base Mismatches at DNA-Modified Surfaces.

10:00 pm Poster Session N (L-Z)

January 25,1998 (Sunday)

8:30 am Conference Business Meeting

Session VI. Small Molecules in Metallotransport and as Model Systems

9:00 am Joan Valentine Comments

9:15 am Carol M. Gorst (Univ. of Michigan) Peptide Models of Mer-R.

9:45 am Wolfgang Ruettinger (Princeton) Synthesis of the First (Mn404)6+ Cubane: A Potential Model for the Photosynthetic Water Oxidase.

10:15 am Craig A. Grappenhaus (Texas A&M) Sulfur Site Reactivity of Nickel Thiolates: ImpUCations for Degradation of Metalloenzymes by Oxygenation.

10:45 am Break

11:00 am Jennifer S. Martinez (UCSB) Iron Acquisition by the Marine Bacteria VibfioTubiashfi.

11:30 am Seth M. Cohen (UC Berkeley) Investigating the pH-Dependent Structural Dynamics of Enterobactin.

12:00 pm Mohammed Attaelmannan (Saskatchewan) Copper(Il)-Lysine Speciation in Ruminant Fluids.