| Thursday, Jan. 28th |
| Joint Session with Metals In Biology |
| 4:00-6:00 pm |
Poster Session # 1 |
| 6:00 pm |
Dinner Break |
| 7:30 pm |
Introduction
Eckard Munck, Carnegie Mellon university |
| 7:45 pm |
"Design and Application of Hydrogen Peroxide Activators"
Terrence J. Collins, Carnegie Mellon University |
| 9:00 pm |
Poster Session # 2 |
| Friday, Jan. 29th |
| Metalloprotein Transcription Factors and Metal Nucleic Acid Interactions |
| 8:20 am |
Conference Photo |
| 8:50 am |
Introduction
Chair: Jacqueline Barton, California Institute of Technology |
| 9:05 am |
"Mossbauer studies of the oxygen-controlled activation/deactivation of the transcription factor FNR in E. coli whole cells"
Codrina Popescu, Carnegie Mellon University |
| 9:35 am |
"Coordination Chemistry and DNA Binding Studies of a Non-Classical Zinc Finger Motif"
Elizabeth Cox, Darmouth University |
| 10:05 am |
"Crystal Structure of a lead-dependent RNA enzyme, metal binding and implications for catalysis by a small ribozyme"
Joseph Wedekind, Stanford University |
| 10:35 am |
"Crystal Structure of a Photoexcitable
Rhodium Intercalator Bound to a DNA Double Helix"
Clara Kielkopf and Kathryn Erkkila, California Institute of Technology |
| 11:05 am |
Coffee Break |
| Enzymatic Synthesis of Metalloprotelin Active Sites |
| 11:35 am |
"Functional Characterization of the Klebsiella aerogenes Urease Nickel Metallochaperone UreE"
Gerry Colpas, Michigan State University |
| 12:05 pm |
"Biosynthesis of the FeMo Cofactor of Nitrogenase: The role of the NifEN complex"
Paul Goodwin, Virginia Polytechnic Institute and State University |
| 12:35 pm |
Lunch and Afternoon Break |
| 4:00-6:00 pm |
Poster Session # 3 |
| Inorganic Complexes as Models for Enzyme Active Sites |
| 7:30 pm |
Introduction
Chair: Richard Holm, Harvard University |
| 7:45 pm |
"L-Edge Soft X-ray Spectroscopy of Ni-Fe Hydrogenase and Ni Models"
Hongxin Wang, University of California, Berkeley |
| 8:15 pm |
"Copper-Dioxygen Reactivity Model Chemistry: Oxo-Transfer to and from a Dicopper Complex"
Christiana Xin Zhang, Johns Hopkins University |
| 8:45 pm |
"A Functional Model for Rieske Dioxygenases: Cis-Dihydroxylation of Olefins by a Nonheme Iron Catalyst"
Kui Chen, University of Minnesota |
| 9:15 pm |
"Synthesis and Characterization of Model Compounds for the Metalloenzyme Nitrile Hydratase"
Dirk Schweitzer, University of Washington |
| 10:00 pm |
Poster Session # 4 |
| Saturday, Jan. 30th |
| Metalloprotein Structure and Function |
| 8:30 am |
Introduction
Chair: Rowena Matthews, University of Michigan |
| 8:45 am |
"Mechanistic Studies on the Bifunctional Acetyl-CoA Synthase found in Clostridium thermoaceticum"
Ernie Maynard, Texas A & M University |
| 9:15 am |
"The Ins and Outs of Ferritin Iron: A Role for the Channel at the Subunit
Trimer Junction"
Hidenori Takagi, Children's Hospital Oakland Research Institute |
| 9:45 am |
"Crystal Structures of Heme Oxygenase"
Dave Schuller, University of California, Irvine |
| 10:15 am |
"The Final Step in Methanogenesis: Mechanism of the Heme- and Iron-Sulfur-Containing Heterodisulfide Reductase"
Eisuke Murakami, University of Nebraska |
| 10:45 am |
Coffee Break |
| 11:05 am |
"Optimization of a [4Fe-4S]2+/+ Binding Peptide for Modular Metalloprotein Design"
Brian R. Gibney, University of Pennsylvania |
| 11:35 am |
"Kinetic Investigation of Topa Quinone Biogenesis"
Joanne Dove, University of Califomia, Berkeley |
| 12:05 pm |
"Very different redox potentials from very similar proteins; the basis for metal-ion specificity in Fe- and Mn- dependent superoxide dismutases"
Carrie Vance, Johns Hopkins University |
|
Afternoon Break |
| Strategies for Oxygen Activation |
| 7:30 pm |
Introduction
Chair: Elizabeth Theil, Children's Hospital Oakland Research Institute |
| 7:45 pm |
"Detection of Reaction Intermediates in the Stearoyl-acyl Carrier Protein Desaturase"
John A. Broadwater, University of Wisconsin, Madison |
| 8:15 pm |
"Oxygen Activation by Diiron Enzymes"
Carsten Krebs, Emory University |
| 8:45 pm |
"Directing Metalloenzyme Substrate Specificity: Introduction of a Site for Manganese Oxidation in
Cytochrome c Peroxidase"
Sheri Wilcox, Scripps Research Institute |
| 9:15 pm |
"Cosubstrate and Substrate Binding to the α-ketoglutatrate-Dependent Non-Heme Iron Enzyme Clavaminate Synthase 2: Coupling Mechanism of Oxidative Decarboxylation and Hydroxylation"
Jing Zhou, Stanford University |
| Sunday, Jan. 31 |
| Novel Zinc Enzymes |
| 8:30-8:45 am |
Introduction
Chair: Bo Malmstrom, University of Goteborg |
| 8:45 am |
"Role of Zinc in the Methylation of Homocysteine in Cobalamin-independent Methionine Synthase from Escherichia coli"
Zhaohui Zhou, University of Michigan |
| 9:15 am |
"Role of a Zinc Metalloenzyme in Activation of Epoxides for the Multiprotein Epoxide Carboxylating System from Xanthobacter Strain Py2"
Jeff Allen, Utah State University |
| 9:45 am |
"Identification of Potential Metal-Coordinating Residues in the Zinc Metalloenzyme UDP-3-0-acyl-
GlcNAc Deacetylase of E. coli"
Jane Jackman, Duke University |
| 10:15 am |
Business Meeting |
| 10:30 am |
Coffee Break |
| Understanding Photosynthesis |
|
Chair: Harry Gray, California Institute of Technology |
| 11:00 am |
"Characterization of Mn oxidation states in photosystern II using high-resolution x-ray fluorescence
spectroscopy"
Uwe Bergman, University of California, Berkeley |
| 11:30 am |
"Photosynthetic Water Oxidation: A metalloradical mechanism"
Johnathan O'Brien, Michigan State University |
| 12:00 pm |
"Amine Binding and Oxidation at the Catalytic Site for Photosynthetic Water Oxidation"
Anthony Ouellette, University of Minnesota |
