Thursday, Jan. 27, 2000
7:30-9:30 pm | Keynote Address |
Stephen J. Lippard
"Cisplatin:From DNA Damage to Anticancer Activity"
Thursday, Jan. 27, 2000
9:30-11pm | Poster Session 1 |
Poster presentations by GRS participants for Metals in Biology participants
Friday Jan. 28, 2000
9am-12:15 pm | Small-Molecule Metal Interactions and Synthetic Active Site Mimics |
Conference Picture, 8:45 am
9:10-9:30 am
Discussion Leader: Julie Kovacs
9:30-10 am
Amy Barrios, Massachusetts Institute of Technology
"Phthalazine-Bridged Dinuclear Nickel(II) Complexes as Models for the Metalloenzyme Urease"
10-10:30 am
Sonia Cunha, Instituto Superior Técnico, Lisboa
"Cyanamide Reduction at a Mo Site"
10:30-10:45 Break
10:45-11:15 am
Matthew Helton, University of New Mexico
"An MCD Spectroscopic Study of Sulfite Oxidase: Implications for the Role of the Cysteine Sulfur and the Pyranopterin in Active and Inhibited Enzyme"
11:15-11:45 am
Hua-Fen Hsu, University of Minnesota
"Is the Carboxylate-Rich Ligation Environment Essential for Dioxygen Activation of Non-heme Diiron Enzymes?"
11:45 am-12:15 pm
Nicolai Tvermoes, UT Austin
"Investigations into the Mode of Action of the Radiation Sensitizer Motexafin Gadolinium (Gd-Tex), using Pulse Radiolysis as a Model for X-Ray Radiation Therapy"
Friday Jan. 28, 2000
4:30-6pm | Poster Session 2 |
Friday Jan. 28, 2000
7:15-9:35 pm | Spectroscopy of Biological Metals |
7:15-7:35 pm
Discussion Leader: Edward Solomon
7:35-8:05 pm
Mark Henson, Stanford University
"Spectroscopic and Electronic Structural Studies of the Cu(III)2 Bis-µ-oxo Core and its Relation to the Side-on Peroxo-bridged Dimer"
8:05-8:35 pm
Amy Palmer, Stanford University
"Specroscopic and Kinetic Characterization of the Peroxide Intermediate of the Multicopper Oxidases"
8:35-9:05 pm
John Robblee, Lawrence Berkeley National Lab
"Absence of Mn-Centered Oxidation in the S2 to S3 Transition: Implications for the Mechanism of Photosynthetic Water Oxidation"
9:05-9:35 pm
TBA
Saturday, Jan. 29, 2000
9am-12:05 | Metalloprotein Structure and Function |
9-9:20 am
Discussion Leader: Marcetta Darensbourg, Texas A&M University
9:20-9:50 am
Jennifer Dubois, Stanford University
"X-Ray Absorption Spectroscopy of the Copper in the Particulate Methane Monooxygenase"
9:50-10:20 am
Ernest Maynard, Texas A&M University
"Digging Deeper into the Catalytic Mechanism of Acetyl CoA Synthase"
10:20-10:35 Break
10:35-11:05 am
Akif Tezcan, California Institute of Technology
"Probing Protein Folding with Substitution-Inert Metal Ions: Folding Kinetics of Cobalt(III)-Cytochrome C"
11:05-11:35 am
Matthew Ryle, Michigan State University
"Stopped-Flow Kinetic Analysis of E.coli Tuarine/α-Ketoglutarate Dioxygenase: Interactions with α-Ketoglutarate, Taurine, and Oxygen"
11:35-12:05
Michele McGuirl, California Institute of Technology
"NosL, a Novel Cu(I) Protein of the Nitrous Oxide Reductatse Gene Cluster"
Saturday, Jan. 29, 2000
4:30-6 pm | Poster Session 3 |
Saturday, Jan. 29, 2000
7:15-9:35 pm | Biological Metal Regulation, Storage, and Transport |
7:15-7:35 pm
Discussion Leader: Thomas O'Halloran
7:35-8:05 pm
Caryn Outten, Northwestern University
"Metalloregulatory Proteins Controlling Zn(II) Uptake and Export in E.coli"
8:05-8:35 pm
Haining Zhu, UCLA
"Purification and Characterization of CCS, a Copper Chaperone for Copper-Zinc Superoxide Dismutase"
8:35-9:05 pm
Markus Ribbe, UC Irvine
"The Glutamic Acid 146 of the Fe Protein of the Nitrogenase is Critical for the Insertion of the FeMo Cofactor into the MoFe Protein"
9:05-9:35 pm
Paul Schmidt, Johns Hopkins University
"The CCS Metallochaperone for Superoxide Dismutase 1"
Sunday, Jan. 30, 2000
9:10 am-12:10 pm | Metal-Nucleic Acid Interactions |
9:10-9:30 am Business Meeting
9:30-9:50 am
Discussion Leader: Cynthia Burrows
9:50-10:20 am
Elizabeth Krider, California Institute of Technology
"Spectroscopy and Electrochemistry of Ruthenium-Modified Oligonucleotides: Tuning the Potentials of Acceptors for DNA Electron Transfer"
10:20-10:50 am
Hans-Achim Wagenknecht, California Institute of Technology
"Oxidation of DNA-bound Tryptophan and Tyrosine through DNA-Mediated Charge Transfer Using the Flash-Quench Technique"
10:50-11:10 Break
11:10-11:40 am
Scott Rajski, California Institute of Technology
"DNA-Mediated Electron Transfer:A Sensitive Probe of DNA-Protein Interactions"
11:40 am-12:10 pm
Seth Cohen, Massachusetts Institute of Technology
"Synthesis of High-Affinity Binding Sites for the TATA Binding Protein"
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