| THURSDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | BANQUET (Joint with Metals in Biology) |
| 7:30 pm - 9:30 pm | JOINT SESSION WITH METALS IN BIOLOGY |
| 7:30 pm - 7:35 pm | F. Ann Walker (University of Arizona), Chair
Introductory Remarks |
| 7:35 pm - 8:35 pm | Vincent Pecoraro (University of Michigan)
"Making Metalloproteins from Scratch: Some Lessons Learned Using de novo Design" |
| 8:45 pm - | Poster Session (Presented by the Gordon Research Seminar) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Conference Photo |
| 9:00 am - 12:30 pm | METALLOPROTEIN STRUCTURE & FUNCTION |
| 9:00 am - 9:15 am | Discussion Leader: Ted Holman (University of California Santa Cruz) |
| 9:15 am - 9:50 am | Timothy F. Henshaw / Robert P. Hausinger (Michigan State)
"Oxidative Demethylation: A Novel Mechanism for Direct Reversal of DNA Damage" |
| 9:50 am - 10:25 am | Vladislav Vrajmasu / Eckard Münck (Carnegie Mellon University)
"Mossbauer Study of Reduced Rubredoxin as Purified and in
Whole Cells. Structural Correlation Analysis of Spin Hamiltonian Parameters" |
| 10:25 am | Coffee Break |
| 10:45 am - 11:20 am | Hemant Joshi / John Enemark (University of Arizona)
"Investigation of Metal-Dithiolate Fold Angle Effects: Implications for Molybdenum Enzymes" |
| 11:20 am - 11:55 pm | Jerome Zoidakis / Mahdi Abu-Omar (UCLA)
"The Brave Phenylalanine Hydroxylase Goes through Trials of Fire and Iron" |
| 11:55 am - 12:30 pm | Liliya Yatsunyk / Ann Walker (University of Arizona)
"Synthesis, Structure and Magnetic Spectroscopies of Non-Planar Hemes as Models of the Cytochromes b" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:00 pm | Poster Session |
| 5:00 pm - 6:00 pm | Tutorial Lecture: Dianne Newman
"Microbe Mineral Interactions: Opportunities for Bioinorganic Chemists" |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MULTINUCLEAR METALLOENZYMES |
| 7:30 pm - 7:40 pm | Discussion Leader: Charles Riordan (University of Delaware) |
| 7:40 pm - 8:10 pm | Tzanko Doukov / Catherine Drennan (MIT)
"A Ni-Fe-Cu Center in a Bifunctional Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase" |
| 8:10 pm - 8:40 pm | Soshanna Zittin Potter / Joan Valentine (UCLA)
"Copper-mediated Ooxygenation of H46C Superoxide Dismutase, an Engineered Copper-cysteinate Protein"
|
| 8:40 pm - 9:10 pm | Raquel Lieberman / Amy Rosenzwieg (Northwestern)
"Biophysical Studies of Particulate Methane Monooxygenase" |
| 9:10 pm - 9:30 pm | Brad Peirce / Mike Hendrich (Carnegie Mellon University)
"Mechanistic Implications for the Formation of the Diiron Cluster in Ribonucleotide Reductase Provided by Quantitative EPR Spectroscopy"
|
| 9:30 pm | Poster Session |
| SATURDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DIOXYGEN ACTIVATION & PROCESSING |
| 9:00 am - 9:15 am | Discussion Leader: Andy Borovik (University of Kansas) |
| 9:15 am - 9:50 am | Trina L. Foster / John Caradonna (Boston University)
"Model Complexes of Binuclear, Non Heme Iron Enzymes: Effective Reactivity and Mechanistic Mimics" |
| 9:50 am - 10:25 am | Ralph Schenker / Thomas Brunold (University of Wisconsin)
"Spectroscopic and Computational Studies on [(PhTt'Bu)Ni]2( -O)2: Nature of the bis-µ-oxo Ni(III)2 "Diamond" Core" |
| 10:25 am - 10:45 pm | Coffee Break |
| 10:45 am - 11:20 am | Lanying D. Quant / Ken Karlin (Johns Hopkins University)
"Dioxygen Activation by Copper(I) Complexes Containing Tridentate Alkyl/Pyridylamine ligands: Electronic Effects on the Formation and Substrate Reactivity of the Cu2O2 Core" |
| 11:20 am- 11:55 am | Peter Larson / A. Borovik (University of Kansas)
"Hydrogen-Bonding Motifs About Metal Ions: Stabilization of a Co(III)-(µ-O)2-Co(III) Core" |
| 11:55 am - 12:30 pm | Jayme Carter / Alison Butler (Univeristy of California Santa Barbara)
Vanadium Haloperoxidase: Enzyme Catalyzed Bromination and Cyclization ofTerpenes and Terpene Analogues" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | METAL ION TRANSPORT & STORAGE |
| 7:30 pm - 7:40 pm | Discussion Leader: Amy Rosenzwieg (Northwestern University) |
| 7:40 pm - 8:10 pm | Minkui Luo / John Groves (Princeton University)
"Amphiphilic Siderophores: Membrane Affinity, Molecular Dynamics and
Iron-aquisition Strategies"
|
| 8:10 pm - 8:40 pm | Emily Dertz / Ken Raymond (Berkeley)
"Iron Uptake in Gram-Positive Bacteria: Corynebactin and Analogs" |
| 8:40 pm - 9:10 pm | Manolis Matzapetakis / Vincent Pecoraro (University of Michigan)
"Structural and Thermodynamic Investidgation of Heavy Metal Binding to Designed Peptides of the TRI Family" |
| 9:10 pm - 9:30 pm | Nathaniel C. Lim / Christian Bruckner (University of Conneticut)
"Novel Fluorescent Sensors for Intracellular Zinc" |
| 9:30 pm | Business Meeting - followed by Poster Session |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:55 am | METALS IN MEDICINE |
| 9:00 am - 9:10 am | Discussion Leader: Mike Clarke (Boston College) |
| 9:10 am - 9:45 am | Laura Dutca / Nenad Kostic (Iowa State University)
"Complex cis-[Pt(en)(H2O)2]2+ as a New Methionine-Specific Protease" |
| 9:45 am - 10:20 am | Alex Dunn / Harry Gray (Caltech)
"Dark-to-Light Luminescent Probes for Metalloenzymes" |
| 10:20 am - 10:55 am | David Puerta / Seth Cohen (University of California, San Diego)
"Using Model Complexes to Explore Novel MMP Inhibitors" |
| 10:55 am - 11:10 am | Coffee Break |
| 11:10 am - 12:30 pm | ENVIRONMENTAL BIOINORGANIC CHEMISTRY |
| 11:10 am - 11:20 am | Discussion Leader: Dianne Newman (California Institute of Technology) |
| 11:20 am - 11:55 am | Chad Saltikov / Dianne Newman (Caltech)
"Molecular Biology of Bacterial Dissimilatory Arsenate Reduction" |
| 11:55 am - 12:30 pm | Patricia M. Pereira / António V. Xavier (Instituto Tecnologia Quimica e Biológical - Universidade Nova de Lisboa)
"Biochemical Characterization of a Type II Tetrahaem Cytochrome from Desulfoviabrio spp a Sulfate Reducing Bacteria" |
| 12:30 pm | Lunch |
| Depart |
