| THURSDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 8:45 pm | JOINT SESSION WITH "METALS IN BIOLOGY" |
| Discussion Leader: Steve Lippard (Massachusetts Institute of Technology) |
| 7:30 pm - 8:30 pm | Thomas V. O'Halloran (Northwestern University)
"Inorganic Physiology of Cancer Cell Proliferation: Targeting Copper Receptor Chemistry" |
| 8:30 pm - 8:45 pm | Discussion |
| 8:45 pm - | Joint Poster Session (presented by the GRS: Bioinorganic Chemistry) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | CELL BIOLOGY OF METALS |
| Discussion Leader: Carol A. Fierke (University of Michigan) |
| 9:15 am - 9:45 am | Nathan Zahler (University of Michigan)
"Effects of cadmium on the subcellular localization of transition metals in Saccharomyces cerevisiae" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Joel Walker (University of Wisconsin)
"The human zinc transporter Zip13 mobilizes zinc from a vesicular compartment" |
| 10:20 am - 10:25 am | Discussion |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:15 am | Amornrat Naranuntarat (Johns Hopkins University)
"Effect of differential metal bioavailability on activity of superoxide dismutase enzymes" |
| 11:15 am - 11:20 am | Discussion |
| 11:20 am - 11:50 am | Paul Cobine (University of Utah)
"The 'ins-and-outs' of mitochondrial copper" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:25 pm | Scott Severance (University of Maryland College Park)
"Functional genomics of heme homeostasis by RNA interference" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 5:00 pm | Free Time (scheduled beach volleyball outing, for those interested) |
| 5:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 8:55 pm | BIO-INSPIRED INORGANIC CHEMISTRY |
| Discussion Leader: Patrick Farmer (University of California - Irvine) |
| 7:45 pm - 8:15 pm | Brandon Green (University of Oregon)
"Peptides and Proteins that Mimic Binding Sites in Blue Copper Proteins" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:50 pm | Frances Namuswe (Johns Hopkins University)
"New models of Superoxide reductase: Influence of the trans ligated thiolate donor in Fe(III)-OOR complexes" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:30 pm | DATA BLITZ |
| (a series of 5-minute presentations on bio-inspired inorganic chemistry) |
| 9:30 pm | Poster Session |
| SATURDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | METALS IN HEALTH AND MEDICINE |
| Discussion Leader: Chris Orvig (University of British Columbia) |
| 9:15 am - 9:45 am | Alberta Bergamo (Callerio Foundation Onlus)
"Comparison of innovative metal-based drugs on the metastatic progression of breast cancer" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Mi Hee Lim (California Institute of Technology)
"DNA strand cleavage near mismatch directed by a rhodium complex" |
| 10:20 am - 10:25 am | Discussion |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:15 am | Delia Zafra (Institute for Research in Biomedicine)
"Mechanism of action of the anti-diabetic compound sodium tungstate" |
| 11:15 am - 11:20 am | Discussion |
| 11:20 am - 11:50 am | Erin Battin (Clemson University)
"A comparison of sulfur and selenium antioxidant activity: Prevention of DNA damage and metal binding" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:25 pm | Jessica Fautch (Purdue University)
"Metal-oxo compounds react with alkylating agents: Toxin interception and implications for cancer prevention" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 5:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 8:55 pm | SPECTROSCOPIC AND COMPUTATIONAL INSIGHTS INTO BIOINORGANIC CHEMISTRY |
| Discussion Leader: Michael Green (Penn State) |
| 7:45 pm - 8:15 pm | Vlad Martin-Diaconescu (University of British Columbia)
"Probing the antioxidant properties of low molecular weight thiols using X-ray absorption spectroscopy" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:50 pm | Wei Jiang (Penn State University)
"A novel heterobinuclear manganese/iron cofactor in Chlamydia trachomatis ribonucleotide reductase" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:30 pm | DATA BLITZ |
| (a series of 5-minute presentations on spectroscopic and computational insights into bioinorganic chemistry) |
| 9:30 pm | Poster Session |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | METALLOPROTEIN STRUCTURE, FUNCTION, AND MECHANISM |
| Discussion Leader: Judith N. Burstyn (University of Wisconsin) |
| 9:15 am - 9:45 am | Christine Phillips (Massachusetts Institute of Technology)
“Structural Basis of Metal Specificity for Nickel Regulatory Protein NikR” |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Anna Davis (Northwestern University)
"Coordination chemistry of the periplasmic copper tolerance protein CusF" |
| 10:20 am - 10:25 am | Discussion |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:15 am | Jan Saam (Charite - Universitätsmedizin Berlin)
"Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels" |
| 11:15 am - 11:20 am | Discussion |
| 11:20 am - 11:50 am | Zhen Ma (Indiana University)
"Structure and mechanism of allosteric switching of the Cu sensor M. tuberculosis CsoR" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:25 pm | Sarah Bowman (University of Rochester)
"NMR investigation of reduction potential tuning within a protein matrix" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm | Depart |
