THURSDAY |
4:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 8:45 pm | JOINT SESSION WITH "METALS IN BIOLOGY" |
| Discussion Leader: David M. Dooley (Montana State University) |
7:40 pm - 8:30 pm | William B. Tolman (University of Minnesota) "Biomimetic Activation of O2 and N2O by Copper" |
8:30 pm - 8:45 pm | Discussion |
8:45 pm | Joint Poster Session (presented by the GRS: Bioinorganic Chemistry) |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | METALLOPROTEINS: FROM FUNCTION TO DE NOVO DESIGN |
| Discussion Leader: Catherine L. Drennan (M.I.T.) |
9:15 am - 9:45 am | Jeremy D. Cook (Wayne State University) "Identifying the Functional Details of Frataxin’s Contribution During Fe-S Cluster Bioassembly" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Seung Jae Lee (University of Maryland) "How does Iron Binding affect the function of Zinc Finger Proteins?" |
10:20 am - 10:25 am | Discussion |
10:30 am - 10:45 am | Coffee Break |
10:45 am - 11:15 am | Eric N. Salgado (University of California, San Diego) "Symmetry of Metal-induced Protein Assemblies Dictated by Metal Coordination Geometry Preferences" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Jolene V. Schuster (Dartmouth University) "Investigation of Cu(I) Binding Thermodynamics of Cellular Proteins Ctr1, Hah1 and ATP7B" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Bennett R. Streit (University of Notre Dame) "Mechanistic and structure-activity study of the O-O bond forming, heme-dependent enzyme, chlorite dismutase" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SPECTROSCOPY OF METALS IN BIOLOGY |
| Discussion Leader: David L. Tierney (University of New Mexico) |
7:45 pm - 8:15 pm | Caleb B. Bell (Stanford University) "Spectroscopic elucidation of factors that tune binuclear non-heme iron active sites for diverse oxygen reactivity" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Sarah Bowman (University of Rochester) "Insight into how the His-Fe(III) interaction in heme proteins modulates reactivity" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Katherine M. Van Heuvelen (University of Wisconsin-Madison) "Insights into the Mechanism of Methyl-Coenzyme M Reductase: Spectroscopic and Computational Studies of Ni-C Bonding in Cofactor F430" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session |
SATURDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | METALS IN INFECTION AND IMMUNOLOGY |
| Discussion Leader: Eric P. Skaar (Vanderbilt University) |
9:15 am - 9:45 am | Sandhya Muralidharan (Wayne State University) "The N-terminal domain of ZntA: its function as a metal chaperone to the transporter" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Claire J Parker Siburt (Duke University) "Hijacking Transferrin-bound Iron: Iron Transport from outside the cell to the periplasm of pathogenic Neisseria gonorrhoeae" |
10:20 am - 10:25 am | Discussion |
10:30 am - 10:45 am | Coffee Break |
10:45 am - 11:15 am | Christine M. Phillips (M.I.T.) "Metal preference at the second metal binding site of E. coli NikR" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Nesha O. Andoy (Cornell University) "Single Molecule Study of Metalloregulator-DNA Interactions" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Maura O’Neill (University of Maryland) "Cytoplasmic Bingding Protein PhuS is Essential for Heme Homeostasis in Pseudomonas aeruginosa" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | BIOINORGANIC MATERIALS IN SENSING AND IMAGING |
| Discussion Leader: Christopher J. Chang (University of California, Berkeley) |
7:45 pm - 8:15 pm | Kenia A. Parga (University of Puerto Rico - Rio Piedras Campus) "Synthesis of Fe8-Based MRI Contrast Agents Targeted to Ovarian Cancer Cells" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Jan L. Vinkenborg (Eindhoven University) "Intracellular zinc imaging using FRET-based sensor proteins" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Philip J. Dittmer (University of Colorado, Boulder) "Genetically encoded FRET based sensors to elucidate spatial distribution of cellular zinc" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session |
SUNDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | DNA, RNA AND METALS |
| Discussion Leader: Jacqueline K. Barton (Cal. Tech.) |
9:15 am - 9:45 am | Brian Zeglis (Cal. Tech.) "Targeting Defects in DNA with Metalloinsertors" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Nandini Nagraj (University of Illinois at Urbana-Champaign) "Probing metal binding of the 8-17 DNAzyme using biophysical and biochemical methods" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 pm | Samuel Pazicni (University of Michigan) "Identification and characterization of a tightly bound metal in the P4 helix of the metallo-ribozyme ribonuclease P" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:10 am | Coffee Break |
11:10 am - 12:30 pm | ENVIRONMENTAL BIOINORGANIC CHEMISTRY |
| Discussion Leader: Rachel N. Austin (Bates College) |
11:20 am - 11:50 pm | Cheryl Saunders (Dalhousie University) "Synthesis and Characterization of Lead-Amino Acid and Mercury-Amino Acid Complexes" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Kathy Batchler (Yale University) "Siderophore Scavenging of Titanium" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm | Departure |