THURSDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 8:45 pm | Joint Session with the Metals in Biology GRC |
| Discussion Leader: Stephen Lippard (Massachusetts Institute of Technology) |
7:30 pm - 8:30 pm | Chuan He (University of Chicago)
"Oxidative Demethylation and Selective Metal Recognition in Biology"
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8:30 pm - 8:45 pm | Discussion |
8:45 pm | Joint Poster Session |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Metals and Human Health |
| Discussion Leader: Liz Nolan (Massachusetts Institute of Technology) |
9:15 am - 9:40 am | Sheel Dodani (UC Berkeley)
"A Chemical Biology Approach for Elucidating New Roles of Copper in Cell Signaling" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Joshua Day (UC San Diego)
"Drug Target Specficity Among Metalloenzyme Inhibitors" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Akiko Kochi (University of Michigan)
"Development of a Small Molecule Targeting Multiple Facets of Alzheimer's Disease" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Subha Bakthavatsalam (TATA Institute of Fundamental Research)
"Illuminating Manganese Induced Neurodegeneration" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Kimberly Lincoln (Texas Christian University)
"A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Bioinorganic Chemistry of Complex Metallocofactors |
| Discussion Leader: Joan Broderick (Montana State University) |
7:45 pm - 8:10 pm | Shawn McGlynn (California Institute of Technology)
"Classifying the Metal Dependence of Uncharacterized Nitrogenases"
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8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Anindya Roy (Arizona State University)
"De novo Design and synthesis of a peptide based functional mimic of [FeFe] hydrogenase"
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8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:30 pm | Data Blitz (a series of 5-minute presentations)
- Cristina Butterfield (Oregon Health & Science University)
- Ben Williams (Bryn Mawr College)
- John Hangasky (University of Massachusetts-Amherst)
- Kate Henderson (Mississippi State University)
- Chelsey Kline (Oregon Health & Science University)
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9:30 pm | Poster Session I |
SATURDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Computational, Spectroscopic, and Structural Characterization of Metalloproteins |
| Discussion Leader: David Britt (UC Davis) |
9:15 am - 9:40 am | Alexey Silakov (Pennsylvania State University)
"The Electronic Structure of P450 Compound I: Implications for Reactivity" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Peter Goldman (Massachusetts Institute of Technology)
"The first look at an AdoMet radical SPASM domain: a 1.6 Å resolution structure of the anaerobic sulfatase maturating enzyme, anSMEcpe" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Matthew Youngblut (University of Wisconsin-Milwaukee)
"Running a Nitrite Reductase in Reverse: A Spectroscopic Study" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Evan Judd (Boston University)
"Direct Electrochemistry of Shewanella oneidensis Cytochrome c Nitrite Reductase: Evidence for Interactions Across the Dimeric Interface" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Laura Dassama (Pennsylvania State University)
"EXAFS Characterization of Intermediate X in the Class Ia Ribonucleotide Reductase from Escherichia coli" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Ni, Cu, and Mn Playing the Role of Iron |
| Discussion Leader: Yi Lu (University of Illinois) |
7:45 pm - 8:10 pm | Lena Daumann (University of Queensland)
"Dinuclear Metallohydrolases and their Biomimetics"
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8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Tom Lawton (Northwestern University)
"Exploring the AMO/pMMO Superfamily"
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8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:30 pm | Data Blitz (a series of 5-minute presentations)
- David Martin (University of California, San Diego)
- Jennifer Rowland (University of Alabama-Birmingham)
- Abiola Olatunde (University at Buffalo)
- Michael Jones (Simon Fraser University)
- Gina Jaggernauth (University of the West Indies)
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9:30 pm | Poster Session II |
SUNDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Design and Synthesis of Metalloproteins |
| Discussion Leader: Squire Booker (Pennsylvania State University) |
9:15 am - 9:40 am | Matthew Reback (Pacific Northwest National Laboratories)
"The Role of a Dipeptide Outer-Coordination Sphere on H2 Production Catalysts: Influence on Catalytic Rates and Electron Transfer"
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9:40 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Isaac Garcia-Bosch (John Hopkins University)
"A Different Approach to the Synthesis of HCO Model Systems: New "Naked" Heme-(O2)-CuII Complexes"
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10:15 am - 10:25 am | Discussion |
10:25 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Saumen Chakraborty (University of Illinois)
"Rational Design of Myoglobin into Structural and Functional Models of Nitric Oxide Reductase"
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11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Alison McQuilken (John Hopkins University)
"Dioxygen and Nitric Oxide Reactivity of a Synthetic Non-heme Iron Model Complex of Cysteine Dioxygenase"
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11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Melissa Zastrow (University of Michigan)
"De Novo Designed Metalloenzymes: Structural Stabilization and Hydrolytic Catalysis in a Family of α-helical Coiled Coils"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm | Departure |