| THURSDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:00 pm | Joint Session with the Metals in Biology GRC: Synthetic Chemistry as a Window into Biology |
| 7:30 pm - 7:45 pm | Discussion Leader: Dan Stack (Stanford University)
"Introduction"
|
| 7:45 pm - 8:45 pm | Andy Borovik (UC Irvine)
"Lessons from Nature: A Bio-Inspired Approach to Molecular Design"
|
| 8:45 pm - 9:00 pm | Discussion |
| 9:00 pm | Joint Poster Session (presented by the Bioinorganic Chemistry GRS) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Bioinorganic Chemistry of Renewable Energy |
| 9:00 am - 9:15 am | Discussion Leader: Hannah Shafaat (Ohio State) |
| 9:15 am - 9:40 am | Van Vu (The Scripps Research Institute)
"Regioselective Hydroxylation of Cellulose by Fungal Polysaccharide Monooxygenases"
|
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Dayn Sommer (Arizona State University)
"De Novo Design of Metal Binding Peptides as Fuel Generating Catalysts"
|
| 10:15 am - 10:25 am | Discussion |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Colin Douglas (University of Toronto)
"The Role of Accessory Proteins in [NiFe]-Hydrogenase Maturation"
|
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Arnab Dutta (Pacific Northwest National Laboratory)
"Appended Proton Channel Enables H2 Oxidation Rates > 100,000 s-1 in Aqueous Solution"
|
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | James Lansing (University of Illinois at Urbana Champaign)
"Catalytic Hydrogen Evolution from Redox Complemented [FeFe]-Hydrogenase Models"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Metals in Medicine, Disease, and Human Health |
| 7:45 pm - 8:10 pm | Discussion Leader: Chris Orvig (University of British Columbia)
"Introduction" |
| 7:45 pm - 8:10 pm | Omoruyi Idemudia (University of Fort Hare)
"Synthesis of New Bioactive Acylpyrazolone Schiff Bases and Their Transition Metal Complexes"
|
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Timothy Johnstone (MIT)
"Nature of the Interaction of the Potent Monofunctional Anticancer Agent Phenanthriplatin with DNA" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Data Blitz (a series of 5-minute presentations) |
|
- Guizella Rocabado (SUNY Buffalo)
"Tetraurea Macrocycles as G-quadruplex Stabilizing Ligands and Further Potential Added Stability by Metal Coordination"
- Kelly Chacon (Oregon Health & Science University)
"Control of the CusCFBA Ag/Cu Efflux Pump in E. coli is Mediated by the Sensor-Switch CusB"
- Marie Heffern (Northwestern University)
"Cobalt(III) Schiff Base Complexes as Zinc Finger Trancription Factor Inhibitors and Amyloid-Beta Binders"
-
Sabyasachi Bandyopadhyay (Indian Association for the Cultivation of Science)
"Bio-Inspired Electrodes Modelling the Active Site of Cytochrome P450: Electronic structure to Reorganization Energy to Reactivity"
- Trinidad Arcos (Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional)
"Spectroscopic and Theoretical Study of Cu(I) Binding to the Fragment 106-115 of the Human Prion Protein"
|
| 9:20 pm - 9:30 pm | General Discussion |
| 9:30 pm | Poster Session I |
| SATURDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Metal Active Sites: Metalloprotein Design and Biomimetic Small Molecules |
| 9:00 am - 9:15 am | Discussion Leader: Vincent Pecoraro (University of Michigan) |
| 9:15 am - 9:40 am | Alison Tebo (University of Michigan)
"Designing an FeS4 Site in a De Novo Designed Peptide"
|
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Ellen Broering (University of Georgia)
"Probing the Electronic Effects of S-ligands and the Influence of Axial N-donors in NiSOD Synthetic Analogues"
|
| 10:15 am - 10:25 am | Discussion |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Fangting Yu (University of Michigan)
"De Novo Designed Metallopeptides with a Type 2 Copper Center: Structural and Functional Models for Copper Nitrite Reductase"
|
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | John Anderson (Caltech)
"Catalytic Conversion of Nitrogen to Ammonia by an Iron Model Complex"
|
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Sohini Mukherjee (Indian Association for the Cultivation of Science)
"Myoglobin Based Biochemical Models of Cytochrome C Oxidase That Reduce O2 Faster Than Native Enzyme"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Radical and Redox Reactions in Bioinorganic Chemistry |
| 7:30 pm - 7:45 pm | Discussion Leader: Catherine L. Drennan (MIT) |
| 7:45 pm - 8:10 pm | Marco Jost (MIT)
"An Old Cofactor in a New Light: B12 in Light-Dependent Gene Regulation"
|
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Benjamin Duffus (Montana State University)
"Defining Radical and Iron-Sulfur Cluster Involvement in Radical AdoMet Enzyme HydG Diatomic Ligand Biosynthesis" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Data Blitz (a series of 5-minute presentations) |
|
- Anthony Gizzi (Albert Einstein College of Medicine)
"A High Throughput Approach to Anaerobic Structural Genomics"
-
Samsuzzoha Mondal (Tata Institute of Fundamental Research)
"Lanthanide Coordination Chemistry for Sensing Signaling Phospholipids"
- Sarah Sirajuddin (Northwestern University)
"Inhibition of Particulate Methane Monooxygenase by Zinc"
- Stephanie Maiocco (Boston University)
"Electrochemical Investigation of the AdoMet Radical Enzyme BtrN from Bacillus circulans"
- Jung Yoon Lee (Johns Hopkins)
"Copper-Oxidase Reactivity Mimetic Behavior: Oxidation/Oxygenation of Phenols by a Copper(II)-Superoxo Complex"
|
| 9:20 pm - 9:30 pm | General Discussion |
| 9:30 pm | Poster Session II |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Spectroscopic and Computational Studies of Metalloproteins |
| 9:00 am - 9:15 am | Discussion Leader: Carsten Krebs (Penn State) |
| 9:15 am - 9:40 am | Amanda Graves (University of Vermont)
"The Mycobacterium Tuberculosis MhuD Active Site Stabilizes a Ruffled Heme with an Unusual Electronic Structure"
|
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | David Heppner (Stanford University)
"Molecular Insights into the Rates of Intramolecular Electron Transfer in the Multicopper Oxidases"
|
| 10:15 am - 10:25 am | Discussion |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | George Cutsail (Northwestern University)
"ENDOR Characterization of a New Iron Catalysis for Nitrogen Reduction"
|
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Gabriele Meloni (Aarhus University / Caltech)
"Principles of Transition Metal Selectivity in Transmembrane P-type ATPase Pumps"
|
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Chao Dong (University of New Mexico)
"Metal-to-Ligand Charge Transfer Probes of Reactivity in Xanthine Oxidase"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm | Departure |
