Thursday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Joint Session with the Metals In Biology GRC: RNRs Diverse Metallo-Cofactors Essential Deoxynucleotide Biosynthesis |
| Discussion Leader: Joseph Martin Bollinger (Pennsylvania State University, USA) |
7:30 pm - 7:45 pm | Introduction by Discussion Leader |
7:45 pm - 8:15 pm | Amie Boal (Pennsylvania State University, USA) "Metallocofactor Assembly in a Novel Manganese-Dependent Class I Ribonucleotide Reductase" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Britt-Marie Sjoberg (Stockholm University, Sweden) "On the Evolution of Ribonucleotide Reductases" |
9:15 pm - 9:30 pm | Discussion |
9:30 pm | Joint Poster Session with Metals in Biology GRC |
Friday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Critical Condition: Metals in Human Health and the Environment |
| Discussion Leader: Ingrid Pickering (University of Saskatchewan, Canada) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Matthew Edmundson (University of Edinburgh, United Kingdom) "Contaminated Land as a Source of Metals for Bacterial Nanoparticle Production, Utilizing Synthetic Biology" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Rodrigo Galindo (University of Utah, USA) "Elucidating Copper Based Drug Induced DNA Base-Pair Eversion" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Erica Majumder (University of Missouri, USA) "Involvement of Thioredoxins from Sulfate Reducing Bacteria in Heavy Metal Reduction" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Kelly Summers (University of Saskatchewan, Canada) "Synchrotron Light in the Study of Alzheimer's Disease: Illuminating the Mechanism of Action of 8-Hydroxyquinoline Drugs" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | George Cutsail (Max Planck Institute for Chemical Energy Conversion, Germany) "Understanding Biological Oxygen Activation for
the Generation of Liquid Fuels" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Darrell Martin (Texas A&M University, USA) "A Class of Its Own: HydY from C. symbiosum Is a H2-Uptake Biased H2O2 Reductase" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Navigating the Landscape: Structure, Folding, and Thermodynamics |
| Discussion Leader: Liliya Yatsunyk (Swarthmore College, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:00 pm | Jennifer Bridwell-Rabb (Massachusetts Institute of Technology, USA) "A Crystallographic Detective Story: Elucidation of the Oxetanocin Biosynthetic Pathway" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Andrew Mitchell (The Pennsylvania State University, USA) "Structural Basis for Selective Chlorination by the Iron-/2-Oxo-Glutarate-Dependent Halogenase WelO5" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Leiah Carey (North Carolina State University, USA) "X-Ray Crystallographic Studies of Substrate Binding to Dehaloperoxidase from Amphitrite Ornata" |
8:50 pm - 8:55 pm | Discussion |
| Data Blitz |
8:55 pm - 9:00 pm | Amanda Baum (Marquette University, USA) "Biologically Relevant Fe(II) Complexes Containing Redox Active (Hydro)Quinone Ligands" |
9:00 pm - 9:05 pm | Karla Ramos-Torres (University of California, Berkeley, USA) "Novel Receptor Platforms for Biological Cu(I) Sensing" |
9:05 pm - 9:10 pm | Seth Cory (Texas A&M University, USA) "Crystal Structure of Eukaryotic Cysteine
Desulfurase" |
9:10 pm - 9:15 pm | Nirupama Singh (University of Alabama in Huntsville, USA) "Bioinspired Nickel and Copper Complexes to Explore Dioxygen Activation Chemistry" |
9:15 pm - 9:20 pm | Christine Romano (Oregon Health and Science University, USA) "Mnx, the Mn(II)-Oxidizing Multicopper Oxidase Complex from Bacillus sp. PL-12" |
9:20 pm - 9:30 pm | General Discussion |
Saturday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Achieving Balance: Homeostasis, Transport, and Biogenesis |
| Discussion Leader: David Giedroc (Indiana University, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Arianna Celis Luna (Montana State University, USA) "The Last Stop on a New Road to Heme" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Carolyn Carr (University of Massachusetts Amherst, USA) "Differential Role of Glutamate Ligands During Metal Response in the E. coli Transcriptional Regulator, RcnR" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Roma Mukhopadhyay (New Mexico State University, USA) "A Redox Sensing Function for the Heme Nitric Oxide/Oxygen Binding Protein (H-NOX) from Vibrio cholerae that Is Independent of Heme Binding." |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Michael Lacasse (University of Toronto, Canada) "Selective Nickel Transfer Between [NiFe] Hydrogenase Maturation Proteins HypB and HypA" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Stephen Dzul (Wayne State University, USA) "In Vitro Characterization of a Novel Primary Scaffold Homologue for De Novo Fe-S Cluster Formation from Drosophila melanogaster" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Rachel Johnson (East Carolina University, USA) "Quantifying the Thermodynamics that Define Calcium Selectivity: A Comparison to Cadmium" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Fitting the Curve: Spectroscopy, Kinetics, and Computation |
| Discussion Leader: R. David Britt (University of California, Davis, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:00 pm | Matthew Conger (University of Vermont, USA) "Second-Sphere Pertubation of IsdG Modulates the Spin Density Distribution of the Heme Substrate" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Lizhi Tao (University of California, Davis, USA) "Mn(II) Oxidation by Multicopper Oxidase MnxG Investigated by Electron Paramagnetic Resonance Spectroscopy" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Bo Zhang (The Pennsylvania State University, USA) "Mechanism of Arylamine N-Oxygenation by the (Hydro)Peroxo-Fe2(III/III) Intermediate in AurF from Streptomyces thioluteus" |
8:50 pm - 8:55 pm | Discussion |
| Data Blitz |
8:55 pm - 9:00 pm | Subrata Kundu (Georgetown University, USA) "Mechanistic Insights into NO to N2O Transformation at a Mononuclear Nickel Site" |
9:00 pm - 9:05 pm | Kanchana Ravichandran (Massachusetts Institute of Technology, USA) "Investigating the Thermodynamic Landscape of the Proton-Coupled Electron Transfer Pathway in Ribonucleotide Reductase Using a Fluorotyrosyl Radical Initiator" |
9:05 pm - 9:10 pm | Sabine Studer (ETH Zürich, Switzerland) "Directed Evolution of a Small Artificial Metalloprotein" |
9:10 pm - 9:15 pm | Amanda Vo (Boston University, USA) "Reconstitution of the Cytosolic Iron-Sulfur Assembly Targeting Complex for Target Recognition" |
9:15 pm - 9:20 pm | Vanessa Chaplin (University of Massachusetts Amherst, USA) "Manipulating Catalytic Activity of HIF Hydroxylases to Control the Hypoxic Response" |
9:20 pm - 9:30 pm | General Discussion |
Sunday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Highest Form of Flattery: Bioinspiration and Synthetic Chemistry |
| Discussion Leader: Carsten Krebs (Pennsylvania State University, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Lee Solomon (Argonne National Laboratory, USA) "Expanding Peptide Amphiphile Functions to Energy and Electrchemical Applications" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Christian Tooley (University of New Hampshire, USA) "Stoichiometric Covalent Binding of Model Diiron Complexes to Polymer Chains" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Benjamin Lin (Harvard University, USA) "Targeting Reactive Polynuclear Clusters" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Lewis Churchfield (University of California, San Diego, USA) "Engineered Metalloprotein Scaffolds Exert Tunable Outer-Sphere Effects on Internalized Metals via Disulfide Bond Networks" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Ramsey Steiner (University of Georgia, USA) "Assessing Potential Mechanisms of Thiolate Protection with Multimetallic Model Complexes of NiSOD" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Samuel Mann (University of California, Irvine, USA) "Artificial Metalloproteins: Towards a Blue Copper Center" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm | Departure |