Thursday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Oxygen, Life in Balance
Discussion Leader: Kara Bren (University of Rochester, USA)
7:30 pm - 7:40 pm
Jennifer Kan (California Institute of Technology, USA)
"Directed Evolution of Cytochrome c for Carbon-Silicon Bond Formation: Bringing Silicon to Life"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Kyle Lancaster (Cornell University, USA)
"Cytochrome P460: A 'New' Leak in the Biogeochemical Nitrogen Cycle"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Hannah Shafaat (The Ohio State University, USA)
"Unraveling the Mn/Fe Lipid-Binding Oxidases: An Investigation of Metal Specificity and Cofactor Assembly in R2lox"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 9:15 pm
Harry Gray (California Institute of Technology, USA)
"Living with Oxygen"
9:15 pm - 9:30 pm
Discussion
9:30 pm - 11:00 pm
Poster Session
Joint Poster Session with the Metals in Biology GRC
Friday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Metals in Pathogenesis, Disease and Medicine
Discussion Leader: Celia Goulding (University of California, Irvine, USA)
9:00 am - 9:10 am
Opening Remarks
9:10 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:40 am
Toshiki Nakashige (Massachusetts Institute of Technology, USA)
"Metal
Sequestration of the Host-Defense Protein Human Calprotectin
"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
Daisy Wong (Western University, Canada)
"Mass Spectrometric Studies of Human Metallothionein and Glutathione Binding to the Anti-Tumour Complex, Dirhodium Tetraacetate"
10:10 am - 10:20 am
Discussion
10:20 am - 10:35 am
Patricia Feliciano (Massachusetts Institute of Technology, USA)
"Fe-S Cluster-Containing Fumarate Hydratase Enzyme as a Drug Target Against Neglected Tropical Diseases"
10:35 am - 10:40 am
Discussion
10:40 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Julia Martin (Indiana University Bloomington, USA)
"Perturbation of Manganese Metabolism Disrupts Cell Division in Streptococcus pneumoniae "
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Sarah Harris (University of Minnesota, USA)
"Altering the Selectivity of Luminescent Terbium Probes for Copper over Zinc via the Number of Sensitizing Phenanthridine Moieties"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Edmund Chun Ming Tse (California Institute of Technology, USA)
"Tracking DNA Damage via a Key Electron Transfer Mechanism Involving Iron-Sulfur Cluster Proteins"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metallocofactor Assembly and Enzyme Mechanisms
Discussion Leader: Markus Ribbe (University of California, Irvine, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Amanda Byer (Montana State University, USA)
"[FeFe]-Hydrogenase Maturase HydF"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Soo Ro (Northwestern University, USA)
"Understanding Particulate Methane Monooxygenase in a Native-Like Environment"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Noah Dunham (Penn State University, USA)
"Mechanistic Insight into Desaturation Reactions by Two Fe(II)/2-(Oxo)glutarate-Dependent Oxygenases"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Derek Gagnon (University of California, Davis, USA)
"An Intermediate in the Radical Addition of S-Adenosyl-L-Methionine to S-VOBA in MqnE"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Elizabeth Blaesi (Pennsylvania State University, USA)
"Insights into the Mechanism of PhnZ, a Peculiar, Mixed-Valent Oxygenase"
9:25 pm - 9:30 pm
Discussion
Saturday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Artificial Protein and Molecular Design
Discussion Leader: Jared Lewis (University of Chicago, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Gozde Ulas (University of California, San Francisco, USA)
"Designed Metalloproteins to Control Radicals"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Anastasia Manesis (Ohio State University, USA)
"Developing Nickel-Substituted Azurin as a Model for Acetyl CoA Synthase"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Ariel Schuelke (University of Vermont, USA)
"Spectroscopy-Guided Design of Synthetic Selective Nickel Chelatases from CbiXS"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Jan Paulo Zaragoza (Johns Hopkins University, USA)
"Direct Observation of Oxygen Rebound in a Synthetic Iron(Hydroxo) Complex"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Victoria Oswald (University of California, Irvine, USA)
"Ligand Design to Support High Valent Metal Oxido/Hydroxido Complexes"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Ruixi Fan (Carnegie Mellon University, USA)
"Characterization of a Novel Fe(V)=O Species Using Mossbauer Spectroscopy"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Kazuki Tanifuji (University of California, Irvine, USA)
"Synthesis, Characterization, and Reactivity of an Asymmetric Synthetic Mimic of the Nitrogenase M-Cluster"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Evaluation Period
Fill in GRS Evaluation Forms
7:30 pm - 9:30 pm
Biological Electron Transfer and Applications in Renewable Energy
Discussion Leader: James Mayer (Yale University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Chang Cui (University of Illinois at Urbana-Champaign, USA)
"A Designed Metalloenzyme Achieving the Catalytic Rate of a Native Enzyme"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
S. Garrett Williams (Arizona State University, USA)
"Electrochemical Comparison of the [FeFe]-Hydrogenases from Clostridium pasteurianum "
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Suzanne Adam (Johns Hopkins University, USA)
"Reactions of o-Catechols with a Heme-Peroxo-Cu Complex Occur via a pKa-Dependent Mechanism: Insights into the Nature of PCET in O2 Reduction"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Mioy Huynh (University of Illinois at Urbana-Champaign, USA)
"Bioinspired [NiFe]- and [FeFe]-Hydrogenase Models for Hydrogen Production"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Functional Insights from Structure and Spectroscopy
Discussion Leader: Petra Fromme (Arizona State University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Franklin Fuller (Lawrence Berkeley National Laboratory, USA)
"High Throughput Transient X-Ray Crystallography and Emission Spectroscopy on the Metalloenzymes at an X-Ray Free Electron Laser"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Ruchira Chatterjee (Lawrence Berkeley National Laboratory, USA)
"Room Temperature Femtosecond X-Ray Crystallography of Photosystem II"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Adam Offenbacher (University of California, Berkeley, USA)
"Towards an Understanding of the Origins of Enzymatic Catalysis in Nature"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Rebeca Gomez Castillo (Max Planck Institute for Chemical Energy Conversion, Germany)
"XAS Investigation of the Q Intermediate of sMMO"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Elizabeth Onderko (Pennsylvania State University, USA)
"Effect of the Axial Ligand on Cytochrome P450 Catalysis"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Cindy Pham (University of California, Davis, USA)
"Terminal Hydride Species in Wild-Type and Variant FeFe Hydrogenases Characterized by Nuclear Resonance Vibrational Spectroscopy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm
Departure