Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Inner Workings of Lung Cells
Discussion Leaders: Cecilia Johansson (Imperial College London, United Kingdom) and Shanley Roach (University of Minnesota, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
Clare Lloyd (National Heart and Lung Institute, Imperial College London, United Kingdom)
"Immune Regulation in the Lung"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Sylvia Knapp (Medical University of Vienna, Austria)
"Postnatal Development of Lung-Specific Immune Homeostasis"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Jay Rajagopal (Massachusetts General Hospital, USA)
"The Airway Epithelial Ensemble"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Viral and Bacterial Infections
Discussion Leaders: Helen Rich (University of Michigan, USA) and Florian Krammer (Icahn School of Medicine at Mount Sinai, USA)
9:00 am - 9:20 am
Paul Duprex (Center for Vaccine Research, University of Pittsburgh, USA)
"Measles Pathogenesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Vicky Sender (Karolinska Institutet, Sweden)
"Pneumococcal Interactions with the Host"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Rebecca Dutch (University of Kentucky, USA)
"Metapneumovirus: How It Goes Cell to Cell"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Philip Molyneaux (National Heart and Lung Institute, Imperial College London, United Kingdom)
"The Airway Microbiome in IPF"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Christopher Brooke (University of Illinois at Urbana-Champaign, USA)
"A Common Pattern of Influenza Virus Single Cell Gene Expression Heterogeneity Governs the Innate Antiviral Response to Infection"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Min Wu (University of North Dakota, USA)
"New Pathogenic Mechanisms Involves Bacterial CRISPR-Cas"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Julia Boehme (Otto von Guericke University Magdeburg, Germany)
"It Ain't Over When It's Over: Recovery from Flu Involves Profound Changes in Antipneumococcal Functions of Alveolar Type II Epithelial Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Rebecca Dutch (University of Kentucky, USA) and Stacey Schultz-Cherry (St. Jude Children's Research Hospital, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Beyond Viral and Bacterial Infections
Discussion Leaders: Jason Rosch (St. Jude Children's Research Hospital, USA) and Rebecca Shears (University of Liverpool, United Kingdom)
7:30 pm - 7:55 pm
Bruce Klein (University of Wisconsin-Madison, USA)
"Immunopathogenesis of Inhaled Fungal Disease"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Judith Allen (University of Manchester, United Kingdom)
"Cytokines, Chemokines and Chitinase-Like Proteins in Recovery from Nematode-Induced Lung Damage"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Chad Steele (Tulane University, USA)
"Novel Innate Resistance Mechanisms Against Invasive Fungal Infections"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Infections in High Risk Populations
Discussion Leaders: Lauren Palmer (Vanderbilt University Medical Center, USA) and Stephania Cormier (Louisiana State University, USA)
9:00 am - 9:20 am
Amali Samarasinghe (University of Tennessee Health Science Center, USA)
"When Influenza Virus Meets Eosin Lovers in Asthma"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Holly Hulsebus (University of Colorado, USA)
"Advanced Age and Alcohol Consumption Alter the Pulmonary Immune Response to Streptococcus pneumoniae "
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Nicholas Heaton (Duke University, USA)
"Differential Antiviral Responses Between Respiratory Epithelial Cell Subtypes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Bethany Moore (University of Michigan, USA)
"Pathogenesis of Infection in Susceptible Hosts"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Kristin Noell (Tulane University School of Medicine, USA)
"B-Cell Antigen Presentation in Lung During Acute Pneumocystis Infection"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Malcolm Starkey (The University of Newcastle, Australia)
"Early-Life Respiratory Infection Suppresses Lung Resident Group 2 Innate Lymphoid Cells and Bronchioalveolar Stem Cells Resulting in Abnormal Lung Development"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Bria Coates (Northwestern University / Ann & Robert H. Lurie Children's Hospital of Chicago, USA)
"The Microenvironment of the Juvenile Lung Promotes Excess Inflammation in Influenza A Virus Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polymicrobial Infections
Discussion Leaders: Dawn Bowdish (McMaster University, Canada) and Farah El Najjar (University of Kentucky, USA)
7:30 pm - 7:55 pm
Jason Rosch (St. Jude Children's Research Hospital, USA)
"Viral Bacterial Interactions During Disease and Transmission"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Elodie Ghedin (New York University, USA)
"Microbial Networking in Respiratory Infections"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Yvonne Huang (University of Michigan, USA)
"Airway Microbiome in Asthma and COPD"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Defining Lung Immunity
Discussion Leaders: Lee Quinton (Boston University School of Medicine, USA) and Mary Lane (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:20 am
Paul Thomas (St. Jude Children's Research Hospital, USA)
"Tolerance, Resistance and Repair as Immunological Strategies Against Influenza"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Simon Phipps (QIMR Berghofer Medical Research Institute, Australia)
"The Influence of Maternal Diet on Microbiome Assembly and Severity of Viral Bronchiolitis in the Offspring"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Andrew Macdonald (University of Manchester, United Kingdom)
"Lung Macrophages and Dendritic Cells in Type 2 Inflammation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Donna Farber (Columbia University Irving Medical Center, USA)
"Generation and Recall of Lung Resident Memory T Cells in Influenza Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Carrie Malinczak (University of Michigan, USA)
"Early-Life Respiratory Viral Infection Leads to Sex-Associated TSLP-Driven Chromatin Remodeling and Trained Immunity"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Juan Dib (Universidad del Norte, Colombia)
"Enteric Helminth Coinfection Protects to Respiratory Disease in Indigenous Population Infected with RSV in the North of Colombia"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Kimberly Barker (Boston University School of Medicine, USA)
"Lung Resident Memory B Cells Are a Common and Functionally Significant Component of Lung Adaptive Immunity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Resident Immune Responses
Discussion Leaders: Chad Steele (Tulane University, USA) and Sarah Londrigan (The University of Melbourne / Peter Doherty Institute for Infection and Immunity, Australia)
7:30 pm - 7:55 pm
Cecilia Johansson (Imperial College London, United Kingdom)
"Regulation of Lung Inflammation Against RSV"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
JoAnne Flynn (University of Pittsburgh School of Medicine, USA)
"The Path to Sterilizing Immunity Against Tuberculosis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Troy Randall (University of Alabama at Birmingham, USA)
"Lung-Resident Memory B Cells in Influenza Infection"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
New Concepts in Lung Infections
Discussion Leaders: JoAnne Flynn (University of Pittsburgh School of Medicine, USA) and Chinedu Idoko (University of Nigeria, Nigeria)
9:00 am - 9:20 am
Peter Openshaw (Imperial College London, United Kingdom)
"Innate Pre-Exposure Status and Prodromal Mucosal Responses Dictate Outcome of Viral Exposure"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Vineet Menachery (University of Texas Medical Branch at Galveston, USA)
"Spike Changes Between SARS-CoV, Bat CoVs, and nCoV-2019 Potentially Alters Virulence In Vivo "
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Elaine Tuomanen (St. Jude Children's Research Hospital, USA)
"Pathogenesis of Pneumonia Interacts with Brain Development"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Nicholas Lukacs (University of Michigan, USA)
"Epigenetics and RSV"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Ryan Langlois (University of Minnesota, USA)
"Dirty Mice as a Model to Better Mimic the Human Immune System for Evaluation of Influenza A Virus Vaccines"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Lauren Palmer (Vanderbilt University Medical Center, USA)
"Mortality from Acinetobacter baumannii Pneumonia During Dietary Zinc Deficiency Is Prevented by Anti-IL-13 Therapy"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Mieszko Wilk (Trinity College Dublin, Ireland)
"IL-10 Induction by Alum-Adjuvanted Acellular Pertussis Vaccines Constrains Their Ability to Induce Protective Respiratory Tissue-Resident Memory CD4 T Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advancing the Therapeutic Strategies for Respiratory Infections
Discussion Leaders: Vineet Menachery (University of Texas Medical Branch at Galveston, USA) and Juan Arias (St. Jude Children's Research Hospital, USA)
7:30 pm - 7:55 pm
Ephraim Tsalik (Duke University School of Medicine, USA)
"The Host Response as a Diagnostic Strategy for Infectious Disease"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Florian Krammer (Icahn School of Medicine at Mount Sinai, USA)
"Hemagglutinin Stalk-Based Universal Influenza Virus Vaccines"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Paul Turner (Yale University, USA)
"Phage Therapy to Combat Infections by Antibiotic-Resistant Bacterial Pathogens"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure