Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Pneumonia in the Experienced Lung
Discussion Leader: Alice Prince (Columbia University, United States)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
Joseph Mizgerd (Boston University School of Medicine, United States)
"Pneumonia and Lung Resident Memory"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
David Masopust (University of Minnesota, United States)
"Respiratory T Cell Immunity"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Andreas Wack (Francis Crick Institute, United Kingdom)
"Alveolar Macrophages and Lung Immunity: Do Prior Infections Matter?"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Vulnerabilities Influencing Pneumonia Susceptibility
Discussion Leader: Bethany Moore (University of Michigan, United States)
9:00 am - 9:30 am
Antoine Roquilly (University of Nantes, France)
"Role of Functional Programing of Alveolar Macrophages in the Susceptibility to Pneumonia After Acute Inflammation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Kymberly Gowdy (The Ohio State University, United States)
"Understanding the Molecular Mechanisms of how Air Pollution Increases Susceptibility to Pulmonary Infections"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Alice Prince (Columbia University, United States)
"Airway Metabolites Shape Susceptibility to Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Riley Pihl (Boston University School of Medicine, United States)
"Investigating Neutrophil Migration and Regulation in Bacterial Models of Pneumonia"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Erin Earnhardt (University of Alabama-Birmingham, United States)
"Influenza A Virus Increases Susceptibility to Streptococcus pneumoniae by Reducing Host Defense in the Airway Surface Liquid"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Sarah Clark (University of Colorado School of Medicine, United States)
"Airway Prevotella Promote TLR2-Dependent Neutrophil Activation and Rapid Clearance of Streptococcus pneumoniae From the Lung"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Taylor Eddens (UPMC Children's Hospital of Pittsburgh, United States)
"Neonatal CD8+ T cells Demonstrate PD-1 Dependent Impairment Following Human Metapneumovirus Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Janet Lee (University of Pittsburgh, United States) and Katrina Traber (Boston University School of Medicine, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Recent Advances in Innate Immunity
Discussion Leader: Kong Chen (University of Pittsburgh, United States)
7:30 pm - 8:00 pm
Claudia Jakubzick (Dartmouth College, United States)
"The Role of moDCs and Interstitial Macrophages in the Lung"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Amanda Jamieson (Brown University, United States)
"Mediating Host Disease Tolerance and Innate Immune Triage: The Lung as a Central Regulator"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Stefanie Vogel (University of Maryland School of Medicine, United States)
"Targeting Host Mediators in Influenza-induced Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immunometabolism for Infection Control
Discussion Leader: Kymberly Gowdy (The Ohio State University, United States)
9:00 am - 9:30 am
Catharine Bosio (Rocky Mountain Laboratories, United States)
"Divergent Outcomes of Acute Lung Infection in the Obese Host"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Michael Fessler (National Institute of Environmental Health Sciences, United States)
"Emerging Roles for Sterols in Pulmonary Defense and Resilience"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Nandini Krishnamoorthy (Brigham and Women's Hospital, United States)
"Roles for Specialized Pro-Resolving Mediators in Airway Inflammation Resolution"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Katharina Ronacher (The University of Queensland, Brisbane, Australia, Australia)
"An Oxysterol Receptor Antagonist Reduces Macrophage Infiltration and Inflammation in the Lung During Influenza and SARS-CoV-2 Infection."
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Kaitlyn Schaaf (Vanderbilt University, United States)
"Influenza A Virus Causes Shedding of the Alveolar Epithelial Glycocalyx through Activation of Sheddases"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Dorothea Morris (University of Texas Medical Branch, United States)
"Investigating the role of HIF1a in hMPV and RSV infections"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Haoran Yang (Tulane University, United States)
"Single-Cell RNA-Sequencing Reveals Unique Metabolic Pathways for Long-Lived CD4+ Tissue-Resident Memory T Cell"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Networks in the Challenged Lung
Discussion Leader: Chad Steele (TULANE UNIVERSITY, United States)
7:30 pm - 8:00 pm
Kara Mould (National Jewish Health, United States)
"Dynamic Programing of Airspace Macrophage Subsets Following Endotoxin Exposure"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Hongbo Luo (Boston Children's Hospital, United States)
"Manipulating Neutrophil Function in the Inflamed Lung"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Asrar Malik (University of Illinois at Chicago, United States)
"Lung Endothelial Cell Regulation of Innate Immunity and Infection Control"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Long-term Sequelae of Respiratory Infections
Discussion Leader: Avery August (Cornell University College of Veterinary Medicine, United States)
9:00 am - 9:30 am
Carlos Orihuela (The University of Alabama at Birmingham, United States)
"Pneumococcal Pneumonia and its Association with Short- and Long-term Risk for Adverse Cardiac Events"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Jie Sun (University of Virginia, United States)
"T cells and Post-Viral Lung Sequelae"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Benjamin Singer (University of Michigan Medical School, United States)
"Persistent Brain Dysfunction in Survivors of Pneumonia and Sepsis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Weishan Huang (Louisiana State University, United States)
"Tissue Resident Foxp3+ Regulatory T Cells During Influenza Infections"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Jacqueline Kimmey (University of California, Santa Cruz, United States)
"Circadian Regulation of Host Response to Streptococcus pneumoniae"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Priyadharshini Devarajan (University of Massachusetts Medical School Worcester, United States)
"Local Ag Presentation to CD4 Effectors in the Lung and Signals from Continuing Infection Acting via Type I IFN and IL-15, Synergize to Drive Tissue-Resident Cytotoxic CD4 T Cell Differentiation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Abhalaxmi Singh (University of Illinois, Chicago, United States)
"Nanoparticle Targeting of de novo Pro-fibrotic Macrophages Mitigates Lung Fibrosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Non-traditional Aspects of Pulmonary Immunity
Discussion Leader: Katrina Traber (Boston University School of Medicine, United States)
7:30 pm - 8:00 pm
DeBroski Herbert (University of Pennsylvania, United States)
"Regulation of Helminth Immunity in the Respiratory Tract"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Janet Lee (University of Pittsburgh, United States)
"Platelet-regulated Neutrophil Responses During Pulmonary Infection"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Haiqing Bai (Xellar Biosystems, United States)
"Understanding Pulmonary Immunity Using Human Organ Chips"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Advances in Pulmonary Defense
Discussion Leader: Anne Sperling (University of Virginia, United States)
9:00 am - 9:30 am
Bart Lambrecht (UGent-VIB-IRC, Belgium)
"Function of APCs in Respiratory Viral Infection: More Than Meets the Eye"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Avery August (Cornell University College of Veterinary Medicine, United States)
"Tuning T Cells for Lung Inflammation and Anti-inflammation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Nicholas Heaton (Duke University, United States)
"Heterogeneity Across Ciliated Cells Before and During Respiratory Viral Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Kaitlyn Rouillard (UNC Chapel Hill, United States)
"Neutrophil Extracellular Traps (NETs) Increase Mucus Viscoelasticity and Promote Bacterial Aggregation"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Zhongli Xu (University of Pittsburgh, United States)
"Integrative Analysis of Spatial Transcriptome with Single-cell Transcriptome and Single-cell Epigenome in Mouse Lungs after Immunization"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Hrishikesh Kulkarni (Washington University School of Medicine, United States)
"Lung Epithelial Cell-derived C3 Protects Against Pneumonia-induced Lung Injury"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Rick van der Geest (University of Pittsburgh, United States)
"BATF2 Mediates Pro-inflammatory Cytokine Production in Macrophages and Enhances Early Host Defense Against Pulmonary Klebsiella pneumoniae Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Resilience and Resolution of Inflammation
Discussion Leader: Charles Dela Cruz (Yale University School of Medicine, United States)
7:30 pm - 8:00 pm
John Alcorn (UPMC Children's Hospital of Pittsburgh, United States)
"Epigenetic and Metabolic Dysfunction During Recovery from Influenza Infection"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Anne Sperling (University of Virginia, United States)
"Type 2 Immunity and Lung Injury"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Rachel Zemans (University of Michigan, United States)
"Regeneration of the Alveolar Epithelium After Acute Respiratory Infection"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure