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Biology of Acute Respiratory Infection (GRS)

Gordon-Merck Research Seminar

Host-Pathogen Interaction in the Lung

February 22 - 23, 2014
Chair Taylor S. Cohen
Renaissance Tuscany Il Ciocco
Via Giovanni Pascoli
Lucca (Barga), Lucca, Italy
 Venue and Travel Information

Conference Description

The Gordon Research Seminar on Biology of Acute Respiratory Infection is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This meeting will focus on the dynamic interaction between bacterial, viral and fungal pathogens and the respiratory innate immune system. Topics will include but are not limited to host receptors and signaling pathways responsible for recognition of pathogens, linking innate and adaptive immunity, and regeneration and repair.

Related Meeting

This GRC will be held in conjunction with the "Biology of Acute Respiratory Infection" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

SATURDAY
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmEpithelial Contribution to Inflammation
Discussion Leader: Katrina Traber (Boston University)
3:15 pm - 3:30 pm Elizabeth Hardaker (Novartis)
"In Vivo Models of Asthma Exacerbations"
3:30 pm - 3:35 pm Discussion
3:35 pm - 3:50 pm Rebecca Bauer (University of North Carolina)
"Decreased Airway Macrophage Phagocytosis in the Context of Oxidant Pollutant Exposure: Role of Interactions with Human Bronchial Epithelial Cells"
3:50 pm - 4:00 pm Discussion
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmInnate Immune Cells
Discussion Leader: Michael Otto (NIAID)
5:30 pm - 5:50 pm Racquel Domingo-Gonzalez (University of Michigan)
"Prostaglandin Synthesis Compromises Neutrophil Extracellular Trap Formation Post-Bone Marrow Transplant"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Fadie Coleman (Boston University)
"Alveolar Macrophage NF-kB-Driven Anti-Pneumococcal Lung Defense is Circumvented by Virulent Pneumococci"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Joel Rasmuson (Karolinska Institutet)
"Neutrophil-Induced Acute Lung Injury Involves the Kallikrein-Kinin System"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Yaron Vagima (Israel Institute for Biological Research)
"Early Recruitment and Homing of Neutrophils to the Lung has a Beneficial Effect Against Y. pestis Airway Infection"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amHost Signaling
Discussion Leader: Lester Kobzik (Harvard School of Public Health)
9:00 am - 9:20 am Anne Van Der Does (Karolinska Institutet)
"Pro-Resolving Activity by the HDAC-Inhibitor Phenylbutyrate Reduces Murine Lung Inflammation During Pseudomonas aeruginosa-Induced Infection"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Megan Meyer (University of North Carolina)
"Sulforaphane, an Antioxidant Found in Broccoli, Decreases Protease Levels and Activity to Lower IAV Activation, Replication, and Infection"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Jenish Patel (Mount Sinai)
"ATPase-Driven Oligomerization of RIG-I on RNA Allows Optimal Activation of Type-I Interferon"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Kristie Hilliard (Boston University)
"The Lung-Liver Axis Facilitates Innate Immunity and Survival During Pneumonia"
10:50 am - 11:00 am Discussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmNovel Regulation of Immune Signaling
Discussion Leader: Kipyegon Kitur (Columbia University)
1:30 pm - 2:20 pm Peter Openshaw (Imperial College London)
"The Pathogenesis of Severe Influenza"
2:20 pm - 2:30 pm Discussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Contributors

Conference Links

Conference History Biology of Acute Respiratory Infection
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