Sunday, January 5 - 7:00 pm

GENETICS OF AGING: THE QUANTITATIVE APPROACH

• Steve Austad, Discussion Leader
• 7:00 - Welcome / Introduction and Orientation
• 7:15 - Jim Curtsinger - "Demographics and quantitative trait locus mapping in Drosophila melanogaster"
• 8:15 - Linda Partridge - "Trade offs between mating and life span of Drosophila melanogaster"
• 8:55 - Michael Rose - "Detection of the genes underlying life extension in selected of Drosophila melanogaster"

Monday, January 6 - 9:00 am

GENETICS OF AGING: THE CLASSICAL APPROACH I

• Cynthia Kenyon, Discussion Leader
• 9:00 - Organizational remarks
• 9:05 - Lenny Guarante - "Genetic analysis of aging in yeast and mammals"
• 9:45 - Gary Ruvkun - "Phosphatidyl inositol signaling in C. elegans: diapause and senescence"
• 10:25 - Cynthia Kenyon - "Mosaic analysis of daf-2"
• 11:30 - Shin Murakami - "Life-extension mutations and downstream genes"
• 12:10 - Valter Longo - "The role of cytoplasmic and mitochondrial SODs in the chronological life span of yeast"

Monday, January 6 - 7:30 pm

GENETICS OF AGING: THE CLASSICAL APPROACH II

• 7:30 - Opening remarks
• Michal Jazwinski, Discussion Leader
• 7:35 - Monica Driscoll - "Degenerative cell death in C. elegans"
• 8:15 - Siegfried Hekimi - "Four 'clock' genes of C. elegans interact to determine lifespan by a novel mechanism"
• 8:55 - Chang-En Yu - "Cloning the Werner's Syndorme gene and an insight into its function"
• 9:35 - Marc Tatar - "Longevity extended by heat-induced expression of Hsp70 in Drosophila melanogaster"

Tuesday, January 7 - 9:00 am

GENETICS OF AGING: THE MOLECULAR APPROACH I

• 9:00 - Organizational remarks
• Arlan Richardson, Discussion Leader
• 9:05 - Michal Jazwinski - "Gene action in yeast longevity"
• 9:45 - Bandana Chatterjee - "Age-responsive changes in the transcriptional control of the androgen receptor and androgen-regulated genes"
• 10:50 - Steve Helfand - "Temporal patterns of gene expression in adult Drosophila melanogaster"
• 11:30 - John Tower - "Aging-specific induction of Drosophila heat shock genes"
• 12:10 - Pamela Larsen - "Mutations in daf-12 and other genes that enhance life span of daf-2(e1370) in double mutants"

Tuesday, January 7 - 7:30 pm

MOLECULAR GENETICS OF AGING II

• John Tower, Discussion Leader
• 7:35 - Steven Stearns - "Experimental evolution of inducible aging"
• 8:15 - Felipe Sierra - "Inhibition of proteolysis during aging: down-regulation of the MAP kinase signaling pathway by thiostatin"
• 8:55 - Vincent Monnier - "Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence"
• 9:30 - Julie Andersen - "Role of the glutathione system in aging and neurodegenerative disease"

Wednesday, January 8 - 9:00 am

GENETICS OF ALZHEIMERS DISEASE

• 9:00 - Organizational remarks
• George Martin, Discussion Leader
• 9:05 - Rudy Tanzi - "Investigations into the etiology of Alzheimer's disease: analysis of the gene responsible for familial Alzheimer's disease"
• 9:45 - Andrea LeBlanc - "Regulation of Alzheimer's disease amyloidogenic pathways in human neurons"
• 10:50 - Samuel Gandy - Molecular and cellular basis of regulating ß-amyloid metabolism and structure"
• 11:30 - Chris Link - "ß-amyloid expression in C. elegans"
• 11:50 - Robert Arking - "Mutational analysis of genes controlling antioxidant activities and longevity in Drosophila"
• 12:10 - Bryant Villeponteau - "Does heterochromatin loss lead to expression of senescent genes and aging?"

Wednesday, January 8 - 7:30 pm

CARDIOVASCULAR REMODELING DURING AGING

• 7:30 - Opening remarks
• 7:35 - Ed Lakatta, Discussion Leader - "Myocardial gene expression changes and resulting phenotypic changes in aging"
• 8:15 - Michael Crow - "Advanced glycation endproducts: receptor-stimulated signal pathways in vascular cells"
• 8:55 - Maurizio Capogrossi - "Gene therapy for vascular diseases that occur in older age"
• 9:35 - Simon Melov - "Attenuation of the lethal phenotype of mice lacking Mn SOD by treatment with a SOD mimetic"

Thursday, January 9 - 9:00 am

GENETICS OF OSTEOPOROSIS

• 9:00 - Organizational remarks
• Arnold Kahn, Discussion Leader
• 9:05 - Steve Cummings - "The epidemiology, causes, and prevention of osteoporotic fractures in women"
• 9:45 - John Eisman - "Vitamin D and estrogen receptor polymophisms and osteoporosis"
• 10:50 - Phil Morin - "Gene mapping of multigenic diseases notably osteoporosis"
• 11:30 - Keiichi Higuchi - "Identification of gene for multiple phenotypes using the SAM mice"
• 12:10 - Richard Miller - "Loci affecting age-sensitive T cell markers, late-life disease and lifespan in four-way cross mice"

Thursday, January 9 - 4:30 pm

KEYNOTE SPEAKER

• 4:30 - Jim Vaupel - ""The prospects of longer lives: findings from biodemographic research"

Thursday, January 9 - 7:30 pm

EVOLUTIONARY TRADE-OFFS BETWEEN LONGEVITY AND REPAIR

• 7:30 - Opening remarks
• Tom Kirkwood, Discussion Leader
• 7:35 - Gordon Lithgow - "Stress-response genes and lifespan"
• 8:10 - Nikki Holbrook - "Molecular responses to stress and aging: evidence for alterations in key signal transduction pathways"
• 8:45 - Arlan Richardson - "Alterations in the heat shock transcription factor 1 are responsible for the age-related deficit in the heat shock response in hepatocytes"
• 9:20 - Axel Kowald - "Theoretical models of molecular aging: help or nuisance"