| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:10 pm | KEYNOTE LECTURE |
| 7:40 pm - 7:50 pm | Discussion Leader: Andrzej Bartke (Southern Illinois University, Springfield, IL, USA) |
| 7:50 pm - 8:40 pm | Steve Helfand (Brown University, Providence, RI, USA)
"Calorie reduction and life span extension: a genetic pathway in the fly" |
| 8:40 pm - 9:10 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:10 pm | IMPACT OF DNA DAMAGE AND REPAIR FUNCTIONS ON AGING |
| 9:00 am - 9:05 am | Discussion Leader: Jan Vijg (Buck Institute for Age Research, Novato CA, USA) |
| 9:05 am - 9:25 am | Dan Gottschling (Fred Hutchinson Cancer Research Center, Seattle WA, USA)
"Yeast Aging and Genomic Instability" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Jan Hoeijmakers (Erasmus University, Rotterdam, The Netherlands)
"Accelerated aging in mice lacking DNA repair proteins" |
| 10:00 am - 10:15 am | Discussion |
| 10:15 am | Group Photo / Coffee Break |
| 11:00 am - 11:20 am | Ignacio Flores (Spanish National Cancer Center, Madrid, Spain)
"Telomeres, DNA repair and aging" |
| 11:20 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Tinna Stevnsner (University of Aarhus, Aarhus, Denmark)
"Mitochondrial DNA repair proteins in aging" |
| 11:55 am - 12:10 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | ACCELERATED AGING |
| 5:30 pm - 5:35 pm | Discussion Leader: Vilhelm Bohr (National Institute of Aging, NIH, Baltimore, MD, USA) |
| 5:35 pm - 5:55 pm | Makoto Kuro-o (University of Texas Southwestern Medical Center, Dallas, TX, USA)
"Regulation of aging by klotho" |
| 5:55 pm - 6:05 pm | Discussion |
| 6:05 pm - 6:25 pm | Tom Misteli (National Cancer Institute, NIH, Bethesda, MD, USA)
"The role of nuclear architecture in aging" |
| 6:25 pm - 6:35 pm | Discussion |
| 6:35 pm - 6:55 pm | Tomas A. Prolla (University of Wisconsin, Madison, WI, USA)
"DNA telomerase gamma mutant mice" |
| 6:55 pm - 7:05 pm | Discussion |
| 7:05 pm - 7:25 pm | Eline Slagboom (Leiden University Medical Center)
"Maintenance of human familial longevity" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PROTEIN FOLDING/AGGREGATION/DEGRADATION IN AGING |
| 9:00 am - 9:05 am | Discussion Leader: Ana Maria Cuervo (Albert Einstein College of Medicine, Bronx, NY, USA) |
| 9:05 am - 9:25 am | Thomas Nyström (Göteborg University, Göteborg, Sweden)
"The role of oxidative carbonylation in protein quality control and senescence" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Andrew Dillin (Salk Institute for Biological Studies, La Jolla, CA, USA)
"Age-associated neuroprotection regulated by insulin/IGF-1 signaling: From worm to mouse" |
| 10:00 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | Rod Levine (National Heart, Lung and Blood Institute, Bethesda, MD, USA)
"Methionine in Proteins: Macromolecular Bodyguards?" |
| 11:05 am - 11:20 am | Discussion |
| 11:20 am - 11:40 am | Bertrand Friguet (University of Paris 7/Denis Diderot, Paris, France)
"Proteasome function in aging" |
| 11:40 am - 11:55 am | Discussion |
| 11:55 am - 12:15 pm | Deborah Ferrington (University of Minnesota, Minneapolis, MN, USA)
"Novel roles for immunoproteasome in aging, stress, and disease" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session II |
| 5:30 pm - 7:25 pm | IMMUNOSENESCENCE / LIPID SIGNALING AND AGING |
| 5:30 pm - 5:40 pm | Discussion Leader: Rita Effros (UCLA, Los Angeles, CA, USA) |
| 5:40 pm - 6:00 pm | Graham Pawelec (University of Tübingen, Tübingen, Germany)
"Acceleration of human immunosenescence by cytomegalovirus" |
| 6:00 pm - 6:15 pm | Discussion |
| 6:15 pm - 6:35 pm | Beatrix Grubeck-Loebenstein (Austrian Academy of Science, Innsbruck, Austria)
"Memory T-cells in aging" |
| 6:35 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:10 pm | Patrick Schrauwen (Maastricht University, Maastricht, The Netherlands)
"Involvement of UCP3 in mild uncoupling and lipotoxicity" |
| 7:10 pm - 7:25 pm | Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | STEM CELLS & AGING |
| 9:00 am - 9:10 am | Discussion Leader: George Martin (University of Washington, Seattle WA, USA) |
| 9:10 am - 9:30 am | Nadia Rosenthal (EMBL Mouse Biology Unit, Monterotondo-Scalo, Italy)
"Aging and stem cells" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Charlotte Peterson (University of Arkansas for Medical Sciences, Little Rock, AR, USA)
"Age-associated changes in muscle stem cells" |
| 10:05 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:10 am | Jonathan Tilly (Harvard Medical School, Boston, MA, USA)
"Stem cells and ovarian aging" |
| 11:10 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | K. Lenhard Rudoph (Medical School Hannover, Germany)
"Exo1 deletion prevents DNA damage signal induction and prolongs lifespan of telomere dysfunctional mice" |
| 11:45 am - 12:00 pm | Discussion |
| 12:00 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session III |
| 5:30 pm - 7:25 pm | THE ROLE OF NUCLEAR RECEPTORS IN AGING |
| 5:30 pm - 5:40 pm | Discussion Leader: Gordon Lithgow (Buck Institute for Age Research, Novato CA, USA) |
| 5:40 pm - 6:00 pm | Adam Antebi (Baylor College of Medicine, Houston, TX, USA)
"Nuclear receptor control of C. elegans development and aging" |
| 6:00 pm - 6:15 pm | Discussion |
| 6:15 pm - 6:35 pm | Gretchen Darlington (Baylor College of Medicine, Houston, TX, USA)
"The role of detoxification pathways in longevity" |
| 6:35 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:10 pm | Chris Corton (US Environmental Protection Agency, Research Triangle Park, NC, USA)
"Alterations in the expression of xenobiotic metabolism genes in mammals by aging and environmental factors" |
| 7:10 pm - 7:25 pm | Discussion |
| 7:25 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | STRESS RESISTANCE AND HEALTH SPAN |
| 9:00 am - 9:05 am | Discussion Leader: Cynthia Kenyon (University of California, San Francisco, CA, USA) |
|
9:05 am - 9:25 am | Monica Driscoll (Rutgers, Piscataway NJ, USA)
"Defining how to age well: Outlining molecular strategies to extend health span" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Tom Johnson (University of Colorado at Boulder, Boulder CO, USA)
"Worm regulation of stress resistance" |
| 10:00 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | Arlan Richardson (South Texas Veteran’s Health Care System-Audie Murphy Division and The University of Texas Health Science Center, San Antonio TX, USA)
"Novel proteomic methods to study the effect of age on protein oxidation and conformation" |
| 11:05 am - 11:20 am | Discussion |
| 11:20 am - 11:40 am | Heinz Osiewacz (Johann Wolfgang Goethe University, Frankfurt am Main, Germany)
"Identification and manipulation of molecular pathways controlling the health span of the fungal ageing model Podospora anserina" |
| 11:40 am - 11:55 am | Discussion |
| 11:55 am - 12:25 pm | 3 Hot Poster Talks (6 min + 4 min discussion each) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session IV |
| 5:30 pm - 7:30 pm | INTERVENTIONS & HEALTHY AGING |
| 5:30 pm - 5:35 pm | Discussion Leaders: Pamela Larsen (University of Texas Health Science Center, San Antonio, TX, USA), Janet Lord (Birmingham University Medical School, Birmingham, UK), David Sinclair (Harvard Medical School, Boston, MA, USA) |
| 5:35 pm - 5:55 pm | Rafael de Cabo (National Institute of Aging, NIH, Baltimore MD, USA)
"In vitro and in vivo analysis of caloric restriction mimetics" |
| 5:55 pm - 6:05 pm | Discussion |
| 6:05 pm - 6:25 pm | Cathy Wolkow (NIA/IRP, Baltimore MD, USA)
"Pharmacologic and genetic approaches to ensure healthy aging in the nematode, C. elegans" |
| 6:25 pm - 6:35 pm | Discussion |
| 6:35 pm - 6:55 pm | Etienne Baulieu (INSERM Unit 788, Paris, France)
"Steroids and healthy aging: From human beings to C. elegans" |
| 6:55 pm - 7:05 pm | Discussion |
| 7:05 pm - 7:25 pm | Charles Brenner (Dartmouth Medical School, Lebanon NH, USA)
"Regulation of NAD+ Biosynthesis in Yeast Replicative Lifespan: Don't Hold the Calories" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
