SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 7:45 pm | Welcome / Introductory Comments by GRC Conference Chairs |
7:45 pm - 9:30 pm | Keynote Address |
7:45 pm - 7:55 pm | Discussion Leader: Rafael de Cabo (NIA/NIH) "Introduction" |
7:55 pm - 8:40 pm | Ian Deary (Edinburgh University, UK) "Intelligence and Lifespan and Lifespan and Intelligence" |
8:40 pm - 9:00 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Structure and Function in the Aging Brain |
9:00 am - 9:05 am | Discussion Leader and Session Chair: George Martin (University of Washington) |
9:05 am - 9:30 am | Heidi Scrable (University of Virginia) "p53, adult neurogenesis and neurodegenerative disease" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | V Hugh Perry (Southampton University, UK) "Impact of systemic inflammation on the aged brain and its consequences" |
10:10 am - 10:25 am | Discussion |
10:25 – 10:35 am | Hot Topic Short Talk: Tae Ho Lee (Harvard University) "The phosphorylation specific isomerase Pin1 regulates TRF1 protein stability, telomere maintenance and aging" |
10:35 am - 10:40 am | Discussion |
10:40 am | Coffee Break |
11:10 am - 11:35 am | Eve van Cauter (University of Chicago) "Impact of sleep and sleep disruption on neuroendocrine and metabolic function" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Gro Amdam (Arizona State University & Norwegian University of Life Sciences) "The plasticity of an aging brain: Understanding reversible learning impairment" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Diseases of Aging: Genetics and Epigenetics |
7:30 pm - 7:35 pm | Discussion Leader and Session Chair: Ed Lakatta (NIA/NIH) |
7:35 pm - 8:00 pm | Lenny Guarente (MIT) "SIRT1 deacetylates and positively regulates the nuclear receptor LXR" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Peter Nelson (University of Kentucky) "miRNAs participate in aging-related neurodegeneration and metabolic pathways" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Jean Pierre Issa (University of Texas, MD Anderson Center) "Progressive tissue specific changes in DNA methylation" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Factors Influencing Muscle Physiology with Age |
9:00 am - 9:05 am | Discussion Leader and Session Chair: Holly van Remmen (South Texas Veterans Health Care System, San Antonio & UTHSCSA) |
9:05 am - 9:30 am | Rolf Bodmer (Burnham Institute for Medical Research) "Physiology and genetics of cardiac aging" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Kenneth Walsh (Boston University) "Body composition changes upon aging: The role of type IIb muscle fibers" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:35 am | Hot Topic Short Talk: William Frazier (Washington University) "CD47 limits mitochondrial biogenesis and exacerbates cardiovascular aging" |
10:35 am - 10:40 am | Discussion |
10:40 am | Coffee Break |
11:10 am - 11:35 am | Pere Puigserver (Harvard University) "Nutrient-Dependent Metabolic Control Through the PGC-1 Pathway: Implications for Aging-Associated Diseases" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Fred Goldberg (Harvard University) "Molecular mechanisms of muscle wasting and the protective effects of exercise" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Aging and Cancer |
7:30 pm - 7:35 pm | Discussion Leaderand Session Chair: Jean Pierre Issa (University of Texas, MD Anderson Center) |
7:35 pm - 8:00 pm | Judy Campisi (Lawrence Berkeley National Laboratory) "Cellular senescence links cancer and aging" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Manuel Serrano (Spanish National Cancer Research Center) "Tumor suppressors in cancer and aging" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Anne Brunet (Stanford University) "FOXO transcription factors in aging and stem cells" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Immunesenescence - Basic Mechanisms and Targets for Intervention |
9:00 am - 9:05 am | Discussion Leader and Session Chair: Arne Akbar (University College London) |
9:05 am - 9:30 am | Janko Nikolich-Zugich (Oregon Health and Science University) "Impact of acute and persistent infection upon function and homeostasis of an aging immune system - dysfunction and repair" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Dennis Taub (NIA/NIH) "Regulation of thymopoiesis by metabolic hormones" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:35 am | Hot Topic Short Talk: Rita Effros (UCLA) "Small molecule telomerase activators: a novel intervention to enhance healthspan" |
10:35 am - 10:40 am | Discussion |
10:40 am | Coffee Break |
11:10 am - 11:35 am | Claudia Gravekamp (California Pacific Medical Center Research Institute) "Are cancer vaccines effective at an older age?" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | John Tower (University of Southern California) "Microbial load, autophagic immunity and drosophila lifespan" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Small Molecule Interventions to Extend Healthspan and Lifespan |
7:30 pm - 7:35 pm | Discussion Leader and Session Chair: Monica Driscoll (Rutgers University) |
7:35 pm - 8:00 pm | Linda Buck (Fred Hutchinson Cancer Research Center) "A high throughput screen for chemicals that delay aging in Caenorhabditis elegans" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | David Kipling (Cardiff University, UK) "Small molecule intervention in stress signaling pathways in Werner Syndrome" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | James Nelson (University of Texas, Health Science Center San Antonio) "Pharmacologic and genetic interventions to probe mechanisms that extend longevity in
mice" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Metabolism and Longevity |
9:00 am - 9:05 am | Discussion Leader and Session Chair: Marc Tatar (Brown University) |
9:05 am - 9:30 am | Michael Karin (University of California, San Diego) "Stress activated kinases and degenerative diseases of obesity and old age" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Leanne Jones (Salk Institute) "Effects of InR signaling on maintenance and aging of the germ line" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:35 am | Hot Topic Short Talk: Sylvia Lee (Cornell University) "Mitochondria signal through key transcription factors to affect longevity in C.elegans" |
10:35 am - 10:40 am | Discussion |
10:40 am | Coffee Break |
11:10 am - 11:35 am | Nir Barzilai (Albert Einstein College of Medicine) "The decline in nutrient sensing mechanisms during mammalian aging" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Christine Loh (Sirtris Pharmaceuticals) "SIRT1 Activation - clinical utility" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Physiological Human Aging |
7:30 pm - 7:35 pm | Discussion Leaders and Session Chairs: Vice Chairs Ana Maria Cuervo (Albert Einstein College of Medicine), Rafael de Cabo (NIA/NIH), and Pidder Jansen-Duerr (Institute for Biomedical Aging Research, Innsbruck) |
7:35 pm - 8:00 pm | Luigi Ferrucci (NIA/NIH) "Baltimore Longitudinal Study: the effects of aging independent of disease" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Chitty Chen (University of Ghent, Belgium) "N-linked sugar protein: N-glycomics and its influence on aging" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Eric Ravussin (Pennington Biomedical Research Center) "Caloric restriction trials in humans" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |