| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | AGING RESEARCH: GETTING ALL THE PIECES TOGETHER |
| Discussion Leaders: Ana Maria Cuervo (Albert Einstein), Rafael de Cabo (NIA) and Pidder Jansen-Duerr (Austrian Academy of Sciences) |
| 7:40 pm - 8:00 pm | Holly Brown-Borg (Univ. North Dakota, Grand Forks, USA)
"Introductory remarks: Resistance to neurodegeneration in long-living Ames dwarf mice" |
| 8:00 pm - 9:00 pm | Keynote Speaker: George Martin (Univ. Washington, Seattle, USA)
"Twelve Modalities of Gene Action that Escape the Force of Natural Selection and thus contribute to Senescent Phenotypes" |
| 9:00 pm - 9:15 pm | Discussion |
| 9:30 pm | Welcome Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CELLULAR SENESCENCE, DNA MODIFICATIONS AND DAMAGE |
| 9:00 am - 9:15 am | Discussion Leader: Estella Medrano (Baylor College of Medicine, Houston, USA) |
| 9:15 am - 9:35 am | Valter Longo (Univ. Southern California)
"Nutrient signaling and age-dependent genomic instability: from yeast to humans" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Xiaoling Li (NIH/NIEHS, Research Triangle Park, NC, USA)
"Metabolic regulation by SIRT1" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | Michael Goligorsky (New York Medical College, Valhalla, USA)
"Stress-Induced Premature Senescence of Endothelial Progenitor Cells" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Jiri Bartek (Danish Cancer Society Copenhagen, Denmark)
"DNA damage signaling: Mechanisms and roles in aging and cancer" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:00 pm | Peter Adams (Cruk Beatson Labs, Glasgow, UK)
"Regulation of chromatin structure in senescent cells by histone chaperones" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Sonia Franco (Johns Hopkins University, Baltimore, USA)
"PARP1 and the ATM network genetically interact to regulate cellular senescence and premature aging" |
| 12:20 pm - 12:25 pm | Discussion |
| 12:30 pm | Group Photo / Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | CELL DEATH AND AGING |
| 5:30 pm - 5:45 pm | Discussion Leader: Beatrix Grubeck-Loebenstein (Institute for Biomedical Aging Research, Innsbruck, Austria) |
| 5:45 pm - 6:05 pm | Frank Madeo (Univ. Graz, Graz, Austria)
"Inhibition of necrosis promotes longevity" |
| 6:05 pm - 6:15 pm | Discussion |
| 6:15 pm - 6:35 pm | Julie K. Andersen (Buck Institute, Novato, USA)
"Oxidative stress and Parkinson's disease:aging as a contributing factor" |
| 6:35 pm - 6:45 pm | Discussion |
| 6:45 pm - 7:00 pm | Richard Miller (U. Michigan, Ann Arbor, USA)
"Resistance to ER and Oxidative Stresses in Long-Lived Mutant Mice" |
| 7:00 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:25 pm | Fabrizio D'adda Di Fagagna (IFOM, Milan, Italy)
"Telomeric DNA damage is irreparable and causes persistent DNA damage response activation and cellular senescence" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MITOCHONDRIA AND CELLULAR OXIDATIVE STRESS |
| 9:00 am - 9:15 am | Discussion Leader: Karin Scharfetter-Kochanek (University of Ulm, Germany) |
| 9:15 am - 9:35 am | Aleksandra Trifonovic (University of Cologne, Cologne, Germany)
"Molecular mechanisms of ageing caused by mitochondrial dysfunction" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Jennifer Gamble (University of Sydney, Newtown, Australia)
"Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | Holly van Remmen (South Texas Veterans HCS, UTHSCSA San Antonio, USA )
"Mitochondrial oxidative stress and neuromuscular degeneration" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Nektarios Tavernarakis (Forth IMBB, Crete, Greece)
"Prohibitin, mitochondrial energy metabolism and ageing in C. elegans" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:05 pm | Eric Verdin (Gladstone Institute of Virology and Immunology)
"Mitochondrial Sirtuins and Aging" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | Open discussion / Burning questions |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session II |
| 5:30 pm - 7:30 pm | STEM CELLS AND AGING |
| 5:30 pm - 5:35 pm | Discussion Leader: Anne Brunet (Stanford University, USA) |
| 5:35 pm - 5:55 pm | Thomas A. Rando (Stanford University, Stanford, USA)
"Epigenetic profiling and functional significance of muscle stem cell aging" |
| 5:55 pm - 6:05 pm | Discussion |
| 6:05 pm - 6:20 pm | Johannes Grillari (University of Applied Live Sciences, Vienna, AU)
"MicroRNA-31 is elevated in the serum of elderly and inhibits osteogenic differentiation of mesenchymal stem cells" |
| 6:20 pm - 6:25 pm | Discussion |
| 6:25 pm - 6:45 pm | Gerald de Haan (University Medical Center Groningen, The Netherlands)
"Aging of hematopoietic stem cells" |
| 6:45 pm - 6:55 pm | Discussion |
| 6:55 pm - 7:10 pm | Victoria Rafalski (Stanford University, Stanford, CA)
"The function of the Sirt1 deacetylase in adult neural stem cells" |
| 7:10 pm - 7:15 pm | Discussion |
| 7:15 pm - 7:25 pm | Judith Haenderler (University of Dusseldorf, Dusseldorf, Germany)
"Endothelial cell aging: molecules and mechanisms" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | AGING AS A HOMEOSTATIC DEFECT |
| 9:00 am - 9:15 am | Discussion Leader: Gordon Lithgow (Buck Institute, Novato, USA) |
| 9:15 am - 9:35 am | William E. Balch (Scripps, La Jolla, USA)
"Proteostasis: Balancing the Yin and Yang in Health and Aging" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Judith Frydman (Stanford University, Stanford, USA)
"Mechanisms controlling protein quality control and aggregation during aging" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | David Rubinsztein (University of Cambridge, UK)
"Autophagy and Neurodegeneration" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:30 am | Alicia Melendez (Queens College, New York, USA)
"Autophagy and lifespan" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Kelvin Davies (University Southern California, Los Angeles, USA)
"Inducibility of the proteasome In oxidative stress, disease, and ageing" |
| 11:55 am - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Marion Schmidt (Albert Einstein College of Medicine, New York, USA)
"The Impact of Proteasome Function on Chronological and Replicative Lifespan in Saccharomyces cerevisiae" |
| 12:20 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | METABOLIC ADAPTATION TO AGING |
| 5:30 pm - 5:40 pm | Discussion Leader: Heidi A. Tissenbaum (Univ. Massachusetts, Worcester, USA) |
| 5:40 pm - 6:00 pm | Shin-ichiro Imai (Washington Univ., St. Louis, USA)
"A New Development in the NAD World: SIRT1, NAMPT-Mediated NAD Biosynthesis, and Their Importance for Metabolism and Aging" |
| 6:00 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:30 pm | Placido Navas (Centro Andaluz Biologia del Desarrollo, Seville, Spain)
"Coenzyme Q connects respiration to metabolism in aging" |
| 6:30 pm - 6:35 pm | Discussion |
| 6:35 pm - 6:55 pm | Pankaj Kapahi (Buck Institute, Novato, USA)
"The role of metabolic changes under dietary restriction in determining lifespan" |
| 6:55 pm - 7:05 pm | Discussion |
| 7:05 pm - 7:25 pm | Marcia Haigis (Harvard University, Cambridge, USA)
"Mitochondrial sirtuins work in concert" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | HUMAN AGING AND UPDATE OF HUMAN LONGITUDINAL STUDIES |
| 9:00 am - 9:15 am | Discussion Leader: Luigi Ferrucci (National Institute on Aging, Baltimore, USA) |
| 9:15 am - 9:35 am | Edward Lakatta (National Institute on Aging, Baltimore, USA)
"Age associated reductions in cardiovascular reserve: perspectives from humans to molecules" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Alexander Buerkle (University of Konstanz, Konstanz, Germany)
"Towards biomarkers of human ageing: The EU FP7 project MARK-AGE" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | Werner Zwerschke (Institute for Biomedical Aging Research, Innsbruck, Austria)
"Impact of long-term caloric restriction on adipose-derived stem cells in formerly obese women" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Bonnie Blomberg (University of Miami, Miami, USA)
"The aging human B cell response" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:05 pm | Rudi Westendorp (Univ. Leiden, Leiden City The Netherlands)
"Hematopoietic capacity and exceptional survival: the Leiden Longevity Study" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session II |
| 5:30 pm - 6:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 6:00 pm - 7:30 pm | INSULIN ACTION AND LONGEVITY: DEBATE |
| Discussion Leaders: Heidi Scrable (Mayo Clinic), Nir Barzilai ( Albert Einstein) and James Kirkland (Mayo Clinic) |
| 6:00 pm - 6:25 pm | Presentation 3 poster winners (5 min each + 2 min disc) |
| 6:25 pm - 6:45 pm | Cynthia Kenyon (University of California, San Francisco, USA)
"Genetic pathways that influence the lifespan of C. elegans" |
| 6:45 pm - 6:55 pm | Discussion |
| 6:55 pm - 7:15 pm | Pinchas Cohen (University of California, Los Angeles, USA)
"Insulin vs. IGF-1 sensitivity and mammalian’s longevity" |
| 7:15 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
