Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Conserved Pathways
Discussion Leader: Sandra Encalada (The Scripps Research Institute, USA)
7:40 pm - 8:20 pm
Gary Ruvkun (Harvard University, USA)
"Immune Surveillance in the Regulation of C. elegans Aging"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Selected from Poster Abstracts: Maarouf Baghdadi (Max Planck Institute for Biology of Ageing, Germany)
"Sexual Dimorphic Role of Neuronal Insulin Signaling on Health Span"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Selected from Poster Abstracts: Karthikeyani Chellappa (University of Pennsylvania, USA)
"NAD Metabolism During Aging: Insight from Quantitative Flux Analysis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Selected from Poster Abstracts: Peter Douglas (University of Texas Southwestern Medical Center, USA)
"Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction and Pathogenesis"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Translational Studies
Discussion Leader: Shin-ichiro Imai (Washington University in St. Louis School of Medicine, USA)
9:00 am - 9:30 am
Nir Barzilai (Albert Einstein College of Medicine, USA)
"How to Die Young at a Very Old Age"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Matt Kaeberlein (University of Washington, USA)
"Targeting Aging Through mTOR Inhibition: New Insights into Mechanisms and Opportunities for Clinical Intervention"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Maria Blasco (Spanish National Cancer Research Centre (CNIO), Spain)
"Targetting Telomeres in Aging and Age-Related Pathologies"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Markus Schosserer (University of Natural Resources and Life Sciences, Vienna (BOKU), Austria)
"Two Specific m5C-Modifications of Ribosomal RNA Modulate Healthy Lifespan and Development"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Kristin Gribble (Marine Biological Laboratory, USA)
"Maternal Age and Maternal Diet Affect Offspring Lifespan, Fitness and Response to Caloric Restriction"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Sandra Encalada (The Scripps Research Institute, USA) and Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chromatin and Epigenetics
Discussion Leader: Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
7:30 pm - 8:00 pm
Raul Mostoslavsky (Massachusetts General Hospital / Harvard Medical School, USA)
"Linking Epigenetics, Metabolism and Cancer: Lessons from SIRT6"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Wolf Reik (The Babraham Institute, United Kingdom)
"Single Cell Epigenome Landscape of Aging"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
John Sedivy (Brown University, USA)
"Activation of Endogenous Retrotransposable Elements as a Mechanism Contributing to Age-Associated Sterile Inflammation"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Genomic Instability
Discussion Leader: Keith Blackwell (Harvard Medical School, USA)
9:00 am - 9:30 am
Vera Gorbunova (University of Rochester, USA)
"SIRT6 in Heterochromatin Silencing and Aging"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
David Sinclair (Harvard Medical School, USA)
"Genes and Small Molecules to Slow the Pace of Aging"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Adam Antebi (Max Planck Institute for Biology of Ageing, Germany)
"Metabolite Signals in Aging"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Diljeet Gill (The Babraham Institute, United Kingdom)
"Examining the DNA Methylation Age Reset that Occurs During iPSC Reprogramming"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Juan Vazquez (University of Chicago, USA)
"Stress Response and a P53 Duplication in the Long-Lived Bat, Myotis lucifugus "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Khyobeni Mozhui (University of Tennessee Health Science Center, USA)
"Methylome-Wide Analysis of Aging and Lifespan in the BXD Inbred Mouse Strains"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolites and Signaling
Discussion Leader: Anne Brunet (Stanford University, USA)
7:30 pm - 8:00 pm
Shin-ichiro Imai (Washington University in St. Louis School of Medicine, USA)
"NAD World 3.0: The Inter-Tissue Interactions Mediated by eNAMPT and NMN in Mammalian Aging/Longevity Control"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Rafael de Cabo (National Institute on Aging, NIH, USA)
"Study of Longitudinal Aging in Mice and Caloric Restriction"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Selected from Poster Abstracts: Andrey Parkhitko (Harvard Medical School, USA)
"Tissue-Specific Manipulations of Methionine and Tyrosine Metabolism Extend Health and Lifespan in Drosophila "
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Selected from Poster Abstracts: Alison Ringel (Harvard Medical School, USA)
"Diet-Induced Obesity Causes Metabolic Reprogramming and Suppresses Immunity in the Tumor Microenvironment"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteostasis
Discussion Leader: Adam Antebi (Max Planck Institute for Biology of Ageing, Germany)
9:00 am - 9:30 am
Jing-Dong Han (Peking University, China)
"Systems Analysis and Systems Intervention of Aging"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Ana Maria Cuervo (Albert Einstein College of Medicine, USA)
"Selective Autophagy in the Remodeling of the Cellular Proteome in Aging"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Cellular Recycling: Role of Autophagy in Aging and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Tapash Sarkar (Stanford University, USA)
"Transient Non-Integrative Epigenetic Reprogramming Promotes Multifaceted Reversal of Aging in Human Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Jarod Rollins (MDI Biological Laboratory, USA)
"The Role of Ribosomal Composition in Selective Translation of Longevity Genes Under Dietary Restriction"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Jette Lengefeld (Massachusetts Institute of Technology, USA)
"Cell Size Determines Stem Cell Potential During Aging"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Nutrient Sensing
Discussion Leader: Isabel Beerman (National Institute on Aging, NIH, USA)
7:30 pm - 8:00 pm
Keith Blackwell (Harvard Medical School, USA)
"Nutrient-Sensing Mechanisms and Longevity"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Michael Ristow (ETH Zurich, Switzerland)
"Redox Regulation of Aging"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Janet Lord (University of Birmingham Medical School, United Kingdom)
"Lifestyle, Trauma and Immune Aging"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells and Clonal Dynamics
Discussion Leader: Dario Riccardo Valenzano (Max Planck Institute for Biology of Ageing, Germany)
9:00 am - 9:30 am
Fernando Camargo (Harvard University, USA)
"Clonal Stem Cells and Aging"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Anne Brunet (Stanford University, USA)
"Epigenetic and Metabolic Regulation of Aging "
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Denis Titov (University of California, Berkeley, USA)
"New Tools for Studying the Role of Energy Metabolism in Physiology and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Duncan Odom (German Cancer Research Center (DKFZ), Germany / Cancer Research UK Cambridge Institute, United Kingdom)
" Comparative Genomics and Transcriptional Aging"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Sibylle Jaeger (L'Oréal Research and Innovation, France)
"PGC-1s Control Epidermal Physiology by Modulating Keratinocyte Proliferation and Terminal Differentiation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Cellular Senescence
Discussion Leader: Ana Maria Cuervo (Albert Einstein College of Medicine, USA)
5:30 pm - 6:10 pm
Cynthia Kenyon (Calico Labs, USA)
"Aging (or Not) in C. elegans "
6:10 pm - 6:20 pm
Discussion
6:20 pm - 6:50 pm
Sandra Encalada (The Scripps Research Institute, USA)
"How Neurons Degenerate in Aging Diseases: Engaging the Neuronal Cytoskeleton in the Biogenesis of Prion Aggregates"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Selected from Poster Abstracts: Vera Pils (University of Natural Resources and Life Sciences, Vienna (BOKU), Austria)
"Lyso-Phospholipids Contribute to the Pro-Inflammatory and Immunomodulatory Activity of Senescent Fibroblasts"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure