Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Conserved Pathways
7:40 pm - 8:20 pm
"Immune Surveillance in the Regulation of C. elegans Aging"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Sexual Dimorphic Role of Neuronal Insulin Signaling on Health Span"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"NAD Metabolism During Aging: Insight from Quantitative Flux Analysis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction and Pathogenesis"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"How to Die Young at a Very Old Age"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Targeting Aging Through mTOR Inhibition: New Insights into Mechanisms and Opportunities for Clinical Intervention"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Targetting Telomeres in Aging and Age-Related Pathologies"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Two Specific m5C-Modifications of Ribosomal RNA Modulate Healthy Lifespan and Development"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Maternal Age and Maternal Diet Affect Offspring Lifespan, Fitness and Response to Caloric Restriction"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chromatin and Epigenetics
7:30 pm - 8:00 pm
"Linking Epigenetics, Metabolism and Cancer: Lessons from SIRT6"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Single Cell Epigenome Landscape of Aging"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Activation of Endogenous Retrotransposable Elements as a Mechanism Contributing to Age-Associated Sterile Inflammation"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:30 am
"SIRT6 in Heterochromatin Silencing and Aging"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Genes and Small Molecules to Slow the Pace of Aging"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Metabolite Signals in Aging"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Examining the DNA Methylation Age Reset that Occurs During iPSC Reprogramming"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Stress Response and a P53 Duplication in the Long-Lived Bat, Myotis lucifugus "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Methylome-Wide Analysis of Aging and Lifespan in the BXD Inbred Mouse Strains"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolites and Signaling
7:30 pm - 8:00 pm
"NAD World 3.0: The Inter-Tissue Interactions Mediated by eNAMPT and NMN in Mammalian Aging/Longevity Control"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Study of Longitudinal Aging in Mice and Caloric Restriction"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Tissue-Specific Manipulations of Methionine and Tyrosine Metabolism Extend Health and Lifespan in Drosophila "
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Diet-Induced Obesity Causes Metabolic Reprogramming and Suppresses Immunity in the Tumor Microenvironment"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Systems Analysis and Systems Intervention of Aging"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Selective Autophagy in the Remodeling of the Cellular Proteome in Aging"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Cellular Recycling: Role of Autophagy in Aging and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Transient Non-Integrative Epigenetic Reprogramming Promotes Multifaceted Reversal of Aging in Human Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"The Role of Ribosomal Composition in Selective Translation of Longevity Genes Under Dietary Restriction"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Cell Size Determines Stem Cell Potential During Aging"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Nutrient-Sensing Mechanisms and Longevity"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Redox Regulation of Aging"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Lifestyle, Trauma and Immune Aging"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells and Clonal Dynamics
9:00 am - 9:30 am
"Clonal Stem Cells and Aging"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Epigenetic and Metabolic Regulation of Aging "
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"New Tools for Studying the Role of Energy Metabolism in Physiology and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
" Comparative Genomics and Transcriptional Aging"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"PGC-1s Control Epidermal Physiology by Modulating Keratinocyte Proliferation and Terminal Differentiation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Cellular Senescence
5:30 pm - 6:10 pm
"Aging (or Not) in C. elegans "
6:10 pm - 6:20 pm
Discussion
6:20 pm - 6:50 pm
"How Neurons Degenerate in Aging Diseases: Engaging the Neuronal Cytoskeleton in the Biogenesis of Prion Aggregates"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
"Lyso-Phospholipids Contribute to the Pro-Inflammatory and Immunomodulatory Activity of Senescent Fibroblasts"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure