Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Environment and Stem Cell Aging
Discussion Leader: Vera Gorbunova (University of Rochester, United States)
7:40 pm - 8:20 pm
Anne Brunet (Stanford University, United States)
"Understanding Aging and Suspended Animation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Michael Wosczyna (NYU School of Medicine, United States)
"Tissue Resident Mesenchymal Stem Cells as Regulators of Skeletal Muscle Aging"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Kristina Kirschner (University of Glasgow/CRUK Beatson Institute, United Kingdom)
"Longitudinal dynamics of clonal haematopoiesis identifies gene-specific fitness effects"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Noga Ron-Harel (Technion-Israel Institute of Technology, Israel)
"Red vs. White: How Failure in Red Blood Cell Recycling Drive T Cell Aging."
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbiome and Diet During Aging
Discussion Leader: Bali Pulendran (Stanford University, United States)
9:00 am - 9:30 am
Michelle Linterman (Babraham Institute, United Kingdom)
"Mechanisms Underpinning Poor Vaccine Responses in Older Individuals"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Filipe Cabreiro (University of Cologne and Imperial College London, Germany)
"Microbiota Polypharmacology for Improving Ageing"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Isabel Gordo (Instituto Gulbenkian de Ciência, Portugal)
"The Tempo and Mode of Evolution of E.coli in the Mammalian Intestine"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Maja Funk (German Cancer Research Center, Germany)
"Aged Intestinal Stem Cells Acquire and Propagate Cell-Intrinsic Sources of Inflammaging"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Clara Correia-Melo (Leibniz Institute for Aging - Fritz Lipman Institute (FLI), Germany)
"Microbial Aging - A Role for Metabolite Exchange Interactions"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Christian Gonzalez-Billault (University of Chile, Chile)
"Cyclic Ketogenic Diet Increase Dendritic Complexity of Cortical Neurons through MAP2 Phosphorylation and BDNF Signaling Pathway Activation in Prefrontal Cortex of Aged Mice"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Dushani Palliyaguru (HealthSurveil , United States) and Samir Morsli (University of Cambridge, United Kingdom)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Immune Aging
Discussion Leader: Michelle Linterman (Babraham Institute, United Kingdom)
6:00 pm - 6:30 pm
María Mittelbrunn (Molecular Biology Center “Severo Ochoa”, CSIC, Spain)
"Immunometabolism at the Crossroad Between Inflammation and Aging"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:10 pm
Naomi Habib (Hebrew University of Jerusalem, Israel)
"Reconstructing Dynamics of Cellular Environments in Aging Brains"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:50 pm
Andrea Ablasser (EPFL, Switzerland)
"The cGAS-STING Pathway Drives Aging-Associated Inflammation and Neurodegeneration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Comparative Biology of Aging
Discussion Leader: Isabel Gordo (Instituto Gulbenkian de Ciência, Portugal)
9:00 am - 9:30 am
Peter Sudmant (University of California Berkeley, United States)
"The Genetics of Aging at Cellular, Organismal, and Population Scales"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Kyoko Miura (Kumamoto University, Japan)
"Regulation of Cell Death and Cellular Senescence in the Long-Lived African Mole-Rats"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Alessandro Ori (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Germany)
"The Proteome of the Aging Vertebrate Brain"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Andrei Seluanov (University of Rochester, United States)
"DNA Repair and Anti-Cancer Mechanisms in the Longest-Living Mammal: The Bowhead Whale"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Silvia Cattelan (Leibniz-Institut für Alternsforschung (FLI), Germany)
"Parental Age Effects on Offspring: Mechanisms and Consequences"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Kristin Gribble (Marine Biological Laboratory, United States)
"Maternal Age Effects on Offspring: Outcomes and Mechanisms"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Technologies to Study Aging
Discussion Leader: Sara Wickstrom (Max Planck Institute for Molecular Biomedicine, Germany)
6:00 pm - 6:30 pm
Alex Cagan (Wellcome Sanger Institute, United Kingdom)
"The Impossibility of Whales: Somatic Mutation Across the Tree of Life"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:15 pm
Tamir Chandra (MRC Human Genetics Unit ; Institute of Genetics & Molecular Medicine, United Kingdom)
"What Drives Age-Related Methylation Dynamics?"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:55 pm
Shahaf Peleg (FBN, Germany)
"Turn your Mito ON! - Towards Energy Replacement in Aging"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Intrinsic Versus Extrinsic Aging
Discussion Leader: Richard Miller (University of Michigan, United States)
9:00 am - 9:30 am
Eva Hoffmann (University of Copenhagen, Denmark)
"Molecular Regulation of Reproductive Aging in Human Females"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Sara Wickstrom (Max Planck Institute for Molecular Biomedicine, Germany)
"Regulation of Stem Cell fate and Aging by Mechanical Forces"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Thomas Vogl (Medical University of Vienna, Austria)
"Deciphering Human Antibody Repertoires against the Microbiome in Ageing"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Helen Morrison (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Germany)
"Macrophages: Key Players in the Aging Peripheral Nerve?"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Myriam Grunewald (Faculty of Medicine, The Hebrew University, Israel)
"Counteracting Age-Related Microvascular Dysfunction extends Health and Lifespan of Mice."
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Guangbo Chen (Stanford, United States)
"Age-Dependent Cytokine Surge in Blood Precedes Cancer Diagnosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Systems Biology of Aging
Discussion Leader: Peter Sudmant (University of California Berkeley, United States)
6:00 pm - 6:50 pm
Keenan Walker (National Institute on Aging (NIA), United States)
"Peripheral Drivers of Alzheimer's Disease and Dementia Identified Using Plasma Proteomics"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:50 pm
Uri Alon (Weizmann Institute of Science, Israel)
"A Circuit Approach to Dissect the Complexity of Aging"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Immune Interventions, Vaccines and Aging
Discussion Leader: Andrea Ablasser (EPFL, Switzerland)
9:00 am - 9:40 am
Benoit Lehallier (Alkahest, United States)
"Molecularizing the Whispers of Aging from Blood to Target Disease"
9:40 am - 10:00 am
Discussion
10:00 am - 10:25 am
Henne Holstege (Amsterdam University Medical Center, The Netherlands)
"Resilience to Cognitive Decline to Escape Dementia: What we can Learn from Cognitively Healthy Centenarians"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Jinte Middeldorp (Department head Neurobiology & Aging, BPRC, Netherlands Antilles)
"Non-Human Primates as Models to Studying Systemic and Brain Aging"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Isabel Beerman (National Institute on Aging, NIH, United States)
"Distinct Male and Female Hematopoietic Aging Phenotypes in Mice"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
Yumi Kim (UNIST, South Korea)
"Ribosome Dynamics during Aging"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Aging therapeutic strategies
Discussion Leader: Jennifer Garrison (Buck Institute for Research on Aging, United States)
6:00 pm - 6:15 pm
Shuhei Nakamura (Osaka University, Japan)
"Microautophagy is Essential to Repair Damaged Lysosomes and Prevent Aging"
6:15 pm - 6:20 pm
Discussion
6:20 pm - 7:00 pm
Paloma Navarro (Stanford, United States)
"Modulating Immune Cells and Inflammation to Rejuvenate the Aged Neurogenic Niche"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:45 pm
Corina Amor (Cold Spring Harbor Laboratory, United States)
"Harnessing Senolytic CAR T Cells to Reverse and Prevent Aging Phenotypes"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
