Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Development of Geroprotectors for the Prevention of Frailty
Discussion Leader: Morten Scheibye-Knudsen (University of Copenhagen, Denmark)
3:15 pm - 3:45 pm
Ilaria Bellantuono (University of Sheffield, United Kingdom)
"The Development of Geroprotectors for the Prevention of Frailty"
3:45 pm - 3:50 pm
Discussion
3:50 pm - 4:00 pm
General Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Molecular Aging to Functional Aging in the Era of Data Science
Discussion Leader: Dennis de Bakker (FLI Jena, Germany)
5:30 pm - 5:55 pm
Mara Neuerburg (Max Planck Institute for Biology of Ageing, Germany)
"In Vitro Functional Characterization of Rare Genetic Variants Identified in Exceptionally Long-lived Individuals"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Jasmin Revanna (University of California, San Diego, United States)
"Microglia Derived From ApoE4 iPSCs Have Alzheimer’s Disease Related Molecular Defects"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Nelly Olova (University of Edinburgh, United Kingdom)
"Accelerated Epigenetic Ageing in Patients With Type I Interferonopathies"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Alan Tomusiak (Buck Institute for Research on Aging, United States)
"Development of a Novel Epigenetic Clock Resistant to Changes in Immune Cell Composition"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Lucy Xu (Stanford University, United States)
"Single-Cell Transcriptomics Reveals Restoration of Neuronal Progenitors in the Old Neurogenic Niche by Partial Reprogramming"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Jingxun Chen (Stanford University - Stanford, CA, United States)
"A Short-Lived Killifish Model for Studying the Interaction Between Aging and Reproduction"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Viktoria Wagner (Saarland University, Germany)
"Aging miRNA Expression Atlas of All Major Organs in Mouse"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Interventions to Promote Healthy Aging
Discussion Leader: Jesus Gil (MRC LMS/imperial College London, United Kingdom)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:25 am
Eleanor Phillips (University of Sheffield, United Kingdom)
"Rapamycin Not Dietary Restriction Improves Resilience Against Pathogens"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Raul Castro (University of Arizona, United States)
"The Current Role of Kynurenine Pathway Interventions in Oxidative Stress and Redox Homeostasis in the Context of Aging and Cancer"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Utkarsh Tripathi (Mayo Clinic, United States)
"A Subset of Senescent Cells With a Tissue-Damaging Phenotype Is Susceptible to Elimination by Senolytics"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Brian Lananna (Washington University in St. Louis, United States)
"eNAMPT-Containing Extracellular Vesicles Mitigate Age-Related Cognitive Decline"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Alina Ryabova (Leibniz Institute on Aging - Fritz Lipmann Institute, Germany)
"Food-Gut-Stool Interplay of the Commensal Bacterial Community in Killifish"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Maarouf Baghdadi (Max Planck Institute for Biology of Ageing, Germany)
"Intermittent rapamycin feeding reduces adverse effects on metabolic health while maintaining lifespan extension in male and female mice"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Chiara Herzog (Universität Innsbruck, Austria)
"Quantifying the Impact of Intermittent Fasting on Multiomic Biomarkers of Aging in a Systems Approach: Preliminary Results From a Longitudinal Lifestyle Intervention Trial"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Aging as a Career
Discussion Leader: Juan Vazquez (Sudmant Lab, University of California - Berkeley, United States)
1:30 pm - 1:40 pm
Introduction by Discussion Leader
1:40 pm - 2:30 pm
Panel Discussion
Aging as a Career
Bita Nakhai (National Institute on Aging, NIH, United States)
Ethan Sarnoski (Cambrian Bio, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
