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Biology of Aging (GRS)

Gordon Research Seminar

Mechanisms and Interventions for Age-Associated Multimorbidity

July 1 - 2, 2023
Chairs and
Rey Don Jaime Grand Hotel
Avinguda de l'Hotel
Castelldefels, Barcelona, Spain
 Venue and Travel Information

Conference Description

The Biology of Aging GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

Understanding and tackling the biology of aging has often involved the study of mechanisms of and treatments for individual age-associated diseases. However, aging encompasses the co-occurrence of multiple physiological, functional and metabolic changes, termed multimorbidity. The 2023 Biology of Aging GRS will focus on multimorbidity and the common signaling pathways between age-associated diseases, with the aim of identifying therapeutic targets with potential to treat multiple conditions simultaneously.

Related Meeting

This GRS will be held in conjunction with the "Biology of Aging" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Development of Geroprotectors for the Prevention of Frailty
Discussion Leader:
3:15 pm - 3:45 pm
"The Development of Geroprotectors for the Prevention of Frailty"
3:45 pm - 3:50 pm
Discussion
3:50 pm - 4:00 pm
General Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Molecular Aging to Functional Aging in the Era of Data Science
Discussion Leader:
5:30 pm - 5:55 pm
"In Vitro Functional Characterization of Rare Genetic Variants Identified in Exceptionally Long-lived Individuals"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"Microglia Derived From ApoE4 iPSCs Have Alzheimer’s Disease Related Molecular Defects"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"Accelerated Epigenetic Ageing in Patients With Type I Interferonopathies"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Development of a Novel Epigenetic Clock Resistant to Changes in Immune Cell Composition"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Single-Cell Transcriptomics Reveals Restoration of Neuronal Progenitors in the Old Neurogenic Niche by Partial Reprogramming"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"A Short-Lived Killifish Model for Studying the Interaction Between Aging and Reproduction"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Aging miRNA Expression Atlas of All Major Organs in Mouse"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Interventions to Promote Healthy Aging
Discussion Leader:
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:25 am
"Rapamycin Not Dietary Restriction Improves Resilience Against Pathogens"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"The Current Role of Kynurenine Pathway Interventions in Oxidative Stress and Redox Homeostasis in the Context of Aging and Cancer"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"A Subset of Senescent Cells With a Tissue-Damaging Phenotype Is Susceptible to Elimination by Senolytics"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"eNAMPT-Containing Extracellular Vesicles Mitigate Age-Related Cognitive Decline"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Food-Gut-Stool Interplay of the Commensal Bacterial Community in Killifish"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Intermittent rapamycin feeding reduces adverse effects on metabolic health while maintaining lifespan extension in male and female mice"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Quantifying the Impact of Intermittent Fasting on Multiomic Biomarkers of Aging in a Systems Approach: Preliminary Results From a Longitudinal Lifestyle Intervention Trial"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Aging as a Career
Discussion Leader:
1:30 pm - 1:40 pm
Introduction by Discussion Leader
1:40 pm - 2:30 pm
Panel Discussion
Aging as a Career
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes

Contributors

National Institutes of Health - National Institute on Aging (NIA)
Estée Lauder
Altos Labs

Research reported in this publication was supported by the National Institute On Aging of the National Institutes of Health under Award Number R13AG082387. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Biology of Aging
Additional Fee Info

Biology of Aging
August 3 - 8, 2025


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