| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | HIJACKING THE HOST CELL |
| Discussion Leader: David Sibley (Washington University, St. Louis, USA) |
| 7:40 pm - 8:00 pm | David Sibley (Washington University, USA)
"Introduction and invasion and virulence in Toxoplasma" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Victor Nussenzweig (New York University, USA)
"Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Herb Tanowitz (Albert Einstein College of Medicine, USA)
"Modulation of Trypanosoma cruzi infection by endothelin and thromboxane" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:05 pm | Dirk Dobbelaere (University of Bern, Switzerland)
"Theileira hijacks mitotic kinases to synchronise host and parasite cytokinesis" |
| 9:05 pm - 9:15 pm | Vernon Carruthers (Michigan University, USA)
"A perforin-like protein is required for rapid cell egress by Toxoplasma gondii" |
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | EPIGENETICS AND GENE EXPRESSION |
| Discussion Leader: Gloria Rudenko (Oxford University, UK) |
| 9:00 am - 9:20 am | Gloria Rudenko (Oxford University, UK)
"Introduction and control of gene transcription in African trypanosomes" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Arthur Günzl (University of Connecticut, Farmington, USA)
"The Trypanosoma brucei class I transcription machinery required for the expression of variant surface glycoprotein and procyclin" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break / Group Photo |
| 10:30 am - 10:50 am | David Mirelman (Weizman Institute, Israel)
"Epigenetic transcriptional silencing of multiple genes in Entamoeba histolytica" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Kirk Deitsch (Weill Cornell Medical College, NY, USA)
"Cellular memory and mutually exclusive expression of virulence genes in Plasmodium falciparum" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Miguel Navarro (Spanish National Research Council)
"RNA Pol II subunit Rpb7 Is required for RNA Pol I mediated transcription in Trypanosoma brucei" |
| 11:40 am - 11:50 am | Luisa Figueiredo (The Rockefeller University, NY, USA)
"A histone methyltransferase modulates antigenic variation in African trypanosomes" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm -12:10 pm | Jose-Juan Lopez-Rubio (Institut Pasteur, Paris, France)
"Genome-wide histone mark analysis reveals a link between the nuclear architecture of P. falciparum and the restricted use of repressive h3k9me3 histone marks to immune escape genes" |
| 12:10 pm - 12:20 pm | Sergio Schenkman (Universidade Federal De Sao Paulo, Brazil)
"Nuclear association of acetylated forms of Trypanosoma cruzi histone H4 with transcription, replication and DNA repair machineries" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PARASITE DEVELOPMENT |
| Discussion Leader: Steve Beverley (Washington University, USA |
| 7:30 pm - 7:50 pm | Stephen Beverley (Washington University, USA)
"Introduction and molecular approaches to differentiation and
virulence in Leishmania" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Andrew Waters (Glasgow University, UK)
"The Silence of the Gams" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Keith Matthews (Edinburgh University, UK)
"Regulating the life cycle of African trypanosomes" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Daniella Bartholomeu (Federal University Of Minas Gerais, Brazil)
"Expression profile of mucin-associated surface protein (MASP) gene family of Trypanosoma cruzi" |
| 9:10 pm - 9:20 pm | Scott Landfear (Oregon Health & Science University, USA)
"Amplification of an alternate transporter gene suppresses the a virulent phenotype of glucose transporter null mutants in Leishmania Mexicana" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | INVASION AND ORGANELLE BIOGENESIS |
| **NOTE**:
Please go to the State Dining Room in the Ochre Court Building for this morning's session ONLY. |
| Discussion Leader: Dominique Soldati (University of Geneva, Switzerland) |
| 9:00 am - 9:20 am | Dominique Soldati (University of Geneva, Switzerland)
"Introduction and the role of specialized organelles in establishment of
parasitism" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Keith Gull (Oxford University, UK)
"The flagellar pocket of trypanosomatids - cellular design for pathogenicity" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Boris Striepen (University of Georgia, Athens, USA)
"Biogenesis and function of the apicomplexan plastid" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Adrian Hehl (University of Zürich, Switzerland)
"Organelle neogenesis and regulated secretion in Giardia lamblia" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Chris De Graffenried (Max F. Perutz Laboratories, Vienna, Austria)
"Polo-like kinase is required for Golgi and bi-lobe biogenesis in Trypanosoma brucei" |
| 11:40 am - 11:50 am | Ira Blader (University of Oklahoma Health Sciences Center, USA)
"Host siRNA screening identifies a critical role for host microtubules in Toxoplasma gondii invasion" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Steve Matthews (Imperial College London, UK)
"New structural insights into microneme protein assembly and host cell recognition by apicomplexans" |
| 12:10 pm - 12:20 pm | Polya Vutova (Karolinska Institute, Sweden)
"Turning a dendritic cell into a trojan horse - modulation of host cell motility by the intracellular parasite Toxoplasma gondii" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | THE PARASITE RNA WORLD |
| Discussion Leader: Shulamit Michaeli (Bar-Ilan University, Israel) |
| 7:30 pm - 7:50 pm | Shulamit Michaeli (Bar-Ilan University, Israel)
"Introduction and RNA biology in trypanosomes" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Isabel Roditi (University of Bern, Switzerland)
"Posttranscriptional regulation in Trypanosoma brucei: a new role for an ancient protein superfamily?" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Barbara Papadopoulou (Laval University, Canada)
"Stage-regulated gene expression in the protozoan parasite Leishmania" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Vivian Bellofatto (New Jersey Medical School-Umdnj, USA)
"A novel HIT- domain protein hydroylzes m7Gpppm662’A, which Is a trypanosome-specific hypermethylated cap structure" |
| 9:10 pm - 9:20 pm | Kristin Patrick (Yale University, New Haven, USA)
"A nuclear Dicer-Like protein (Dcl2) processes repeat-derived siRNAs in the Trypanosoma brucei RNA interference pathway" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | BIOCHEMISTRY AND DRUG DISCOVERY |
| Discussion Leader: Margaret Phillips (University of Texas South Western, USA) |
| 9:00 am - 9:20 am | Margaret Phillips (University of Texas South Western, USA)
"Introduction and targeting novel parasite biochemistry for drug discovery" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Dan Goldberg (Washington University, USA)
"Determining essentiality and function of a plasmodium protein" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Paul Wyatt (Dundee University, UK)
"Discovery of drugs for African sleeping sickness in an academic setting" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Robert Jacobs (SCYNEXIS)
"Advanced screening and drug discovery methodologies applied to human African trypanosomiasis" |
| 11:20 pm - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Abdoulaye Djimde (Malaria Research Centre, Bamako, Mali)
"Host determinants of the clearance of drug resistant malaria parasites" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:00 pm | Utpal Tatu (Indian Institute of Science, Bangalore, India)
"Molecular chaperones in Plasmodium falciparum: heat-shock protein 90" |
| 12:00 pm - 12:10 pm | Alberto Gimenez (Institute for Pharmaceutical and Biochemical Research, La Paz, Bolivia)
"Traditional medicine a reliable source for new natural antiparasitic agents" |
| 12:10 pm - 12:20 pm | Enock Matovu (Makerere University, Kampala, Uganda)
"Difluoromethylornithine (DFMO) relapses amongst late-stage T. b. gambiense patients treated at Omugo Health Center, Northwest Uganda" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | INTERFACING FUNCTION AND GENOMICS |
| Discussion Leader: David Roos (Pennsylvania University, Philadelphia, USA) |
| 7:30 pm - 7:50 pm | David Roos (Pennsylvania University, Philadelphia, USA)
"Introduction and integrating ‘Omics’ datasets" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Dyann Wirth (Harward University, USA)
"Genetic diversity in Plasmodium falciparum: role in parasite biology and drug resistance" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Michael Barrett (Glasgow University, UK)
"Trypanosome metabolomics" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Gerald Spaeth (Pasteur Institute, Paris, France)
"Identification of a foldosome complex in Leishmania donovani by quantitative phosphoproteomics and 2D blue native PAGE" |
| 9:10 pm - 9:20 pm | Igor Almeida (University of Texas at El Paso, USA)
"GPIomics of Trypanosoma cruzi reveals the cell surface complexity" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | VECTOR BIOLOGY |
| Discussion Leader: José Ribeiro (National Institutes of Health, USA) |
| 9:00 am - 9:20 am | José Ribeiro (National Institutes of Health, USA)
"Vector parasite relationship in the post genome era: perspectives and
challenges" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Serap Aksoy (Yale University, USA)
"Tsetse reproductive fitness compromised by immunogenic trypanosome infections and its potential impact on disease dynamics" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Jesus Valenzuela (National Institutes of Health, USA)
"A multidisciplinary approach to understand the role of vector proteins in pathogen transmission" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Kenneth Vernick (Pasteur Institute, France)
"Genome-wide functional dissection of natural pathogen resistance in Anopheles gambiae mosquitoes" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Mamadou Coulibaly (Malaria Research Center, Bamako, Mali)
"Impact of Plasmodium falciparum infection on reproduction in M and S molecular forms of Anopheles gambiae" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:00 pm | Felipe Lopes (Federal University Rio De Janeiro, Brazil)
"Parasite-derived glycoconjugates down-regulate insect nitric oxide synthase expression and salivary antihemostatic activities" |
| 12:00 pm - 12:10 pm | Anil Ghosh (Johns Hopkins School of Public Health, Baltimore, USA)
"What a peptide taught us about Plasmodium invasion of the mosquito midgut" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | FRONTIERS IN PARASITE IMAGING |
| Discussion Leader: Markus Engstler (Darmstadt University of Technology, Germany) |
| 7:30 pm - 7:50 pm | Markus Engstler (Darmstadt University of Technology, Germany)
"Expensive details: does parasitology really benefit from cutting-edge imaging?" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Ute Frevert (New York University, USA)
"From the skin via the liver to the brain: imaging Plasmodium in the vertebrate host" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Thomas Cremer (Ludwig-Maximilians-University, Martinsried, Germany)
"Chromosome territories and nuclear organization: structural, functional and evolutionary aspects" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Bamini Jayabalasingham (Johns Hopkins Bloomberg School of Public Health, Baltimore, USA)
"Plasmodium sporozoites on the verge of an organellar breakdown" |
| 9:10 pm - 9:20 pm | Pascale Gueirard (Pasteur Institute, Paris, France)
"Complete development of mammal-infecting plasmodia in the skin of the host" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
