SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | Transmission of parasites |
| Discussion Leader: David Sacks (NIH, Bethesda, USA) |
7:35 pm - 7:55 pm | Sacks, David (NIH, Bethesda, USA) "The cell biology of parasite-vector interactions in Leishmaniasis" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Bates, Paul (Liverpool School of Tropical Medicine, UK) "Transmission mechanisms of leishmaniasis" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Tait, Andy (University of Glasgow, UK) "Genetic exchange in African Trypanosomes" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:30 pm | Short Talks |
9:05 pm - 9:15 pm | Smith, Nick (University of Sydney, Australia) "The molecular basis for the transition from gametocyte to oocyst in coccidian parasites" |
9:15 pm - 9:18 pm | Discussion |
9:18 pm - 9:28 pm | Morahan, Belinda (NIAID/NIH, Bethesda, USA) "Plasmodium falciparum Gametocytogenesis" |
9:28 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Phenotypic variation, RNA and gene expression |
| Discussion Leader: Elisabetta Ullu (Yale University, USA) |
9:00 am - 9:20 am | Ullu, Elisabetta (Yale University, USA) "RNA interference and gene regulation in Trypanosoma brucei" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Llinas, Manuel (Princeton University, USA) "Stage-specific transcriptional regulation by ApiAP2 proteins" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Group Photo / Coffee Break |
10:30 am - 10:50 am | Lujan, Hugo (University of Cordoba, Argentina) "The RNAi machinery controls antigenic variation in the intestinal parasite Giardia lamblia" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Singh, Upinder (Stanford University, USA) "An unusual repertoire of small RNAs and RNAi genes regulate gene expression in Entamoeba histolytica" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:30 pm | Short Talks |
11:30 am - 11:40 am | Chene, Arnaud (Institut Pasteur, France) "A new family of DNA-binding proteins in P. falciparum" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Kishore, Sandeep (Cornell University, USA) "A primate malaria parasite-specific pathway for epigenetic memory of multi-copy virulence genes" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Le Roch, Karine (University of California Riverside, USA) "Genome-wide nucleosome positioning and DNA methylation in the human malaria parasite: Insights into differentiation and virulence" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Roditi, Isabel (University of Berne, Switzerland) "Sequence-specific mRNP isolation identifies a translational repressor in T. brucei" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Host and parasite genetic variation in disease |
| Discussion Leader: Xin-zhuan Su (NIAID/NIH, USA) |
7:30 pm - 7:50 pm | Su, Xin-zhuan (NIAID/NIH, USA) "Genetic variation and genetic mapping genes contributing to drug response and virulence in malaria parasites" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Hajduk, Stephen (University of Georgia, USA) "Alternative mRNA editing expands T. brucei mitochondrial protein diversity" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Beverly, Steve (Washington University, USA) "Genetic crossing as a tool for probing Leishmania virulence and tropisms" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:30 pm | Short Talks |
9:00 pm - 9:10 pm | Sterkers, Yvon (University of Montpellier, France) "Generation of chromosome aneuploidy and mosaicism in Leishmania" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Taraschi, Theodore (Thomas Jefferson University, USA) "Malaria Drug Resistance is Associated with DNA Mismatch Repair Deficiency" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Invasion and egress from host cells |
| Discussion Leader: Alan Cowman (WEHI, Melbourne, Australia) |
9:00 am - 9:20 am | Cowman, Alan (WEHI, Melbourne, Australia) "Alternate merozoite invasion pathways used by P. falciparum to invade human erythrocytes" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Carruthers, Vern (University of Michigan, Ann Arbor, USA) "Cell to cell transmission of Toxoplasma gondii" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Coffee Break |
10:15 am - 10:35 am | Blackman, Mike (National Institute of Medical Research, Mill Hill, UK) "Malarial proteases in invasion and egress" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Soldati, Dominique (University of Geneva, Switzerland) "Mechanisms controlling glideosome function in apicomplexans" |
11:05 am - 11:15 am | Discussion |
11:15 am - 12:30 pm | Short Talks |
11:15 am - 11:25 am | Duraisingh, Manoj (Harvard University, USA) "Genetic analyses of parasite and erythrocyte determinants of P. falciparum egress and invasion" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Skillman, Kristen (Washington University, USA) "Molecular Basis of Divergent Unstable Actins in Apicomplexan Parasites" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Martins, Rafael (Sao Paulo, Brazil) "Molecular mimicry in the context of host cell invasion by T. cruzi" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Sinis, Photini (New York University, USA) "Conformational Changes in the Circumsporozoite Protein Are Required for the Establishment of Malaria Infection" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Greenbaum, Doron (University of Pennsylvania, USA) "Apicomplexan parasites co-opt host calpain proteases for efficient egress from the host cell" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Systems biology |
| Discussion Leader: Elisabeth Winzeler (Genomics Institute of the Novartis Research Foundation, San Diego, USA) |
7:30 pm - 7:50 pm | Winzeler, Elisabeth (Genomics Institute of the Novartis Research Foundation, San Diego) "Chemical and population genomics of malaria" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Kami, Kim (Albert Einstein College of Medicine, New York, USA) "Using Epigenomics to Understand Gene Expression in Toxoplasma gondii" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Roos, David (University of Pennsylvania, USA) "Integrating diverse datasets to define key biological traits: Towards a systems biology of host-parasite interactions" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:30 pm | Short Talks |
9:00 pm - 9:10 pm | McNamara, Case (Genomics Institute of the Novartis Research Foundation, USA) "Using systems approaches to discover the targets of small molecules with antimalarial activity" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Olszewski, Kellen (Princeton University, USA) "Metabolomic QTL analysis implicates PfCRT as a small peptide transporter" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Trafficking and organelle biogenesis |
| Discussion Leader: Boris Striepen (University of Georgia, Athens, USA) |
9:00 am - 9:20 am | Striepen, Boris (University of Georgia, Athens) "Biology of the apicomplexan plastid" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Haldar, Kasturi (University of Notre Dame, USA) "The malaria secretome: from algorithms to essential functions" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Coffee Break |
10:15 am - 10:35 am | Bastin, Philippe (Institut Pasteur, Paris) "Constructing the trypanosome flagellum: a puzzle of 300 proteins" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Bangs, Jay (University of Wisconsin-Madison, USA) "GPI's, sphingolipids, and secretory trafficking in African trypanosomes" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Desai, Sanjay (NIAID/NIH, USA) "The plasmodial surface anion channel: cloning and validation as an antimalarial target" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:30 pm | Short Talks |
11:45 am - 11:55 am | Hehl, Adrian (University of Zurich, Switzerland) "Indirect epigenetic control of a small set of genes drives encystation in Giardia lamblia" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Robinson, Derrick (University of Bordeaux, France) "The identification and characterization of flagellar pocket collar proteins in T. brucei" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Matthews, Steve (Imperial College, UK) "Atomic resolution basis for host cell recognition by apicomplexan parasites" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Cell cycle and development |
| Discussion Leader: Keith Matthews (University of Edinburgh, UK) |
7:30 pm - 7:50 pm | Matthews, Keith (University of Edinburgh, UK) "Regulating transmission by African trypanosomes" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Billker, Oliver (The Wellcome Trust Sanger Institute, Cambridge, UK) "Regulation of malaria development in the mosquito" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Coppens, Isabelle (Johns Hopkins University, Baltimore, USA) "Apicomplexan parasites: Insights into the developmental transformations of the sporozoite stage" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:30 pm | Short Talks |
9:00 pm - 9:10 pm | Dobbelaere, Dirk (University of Berne, Switzerland) "Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Dawson, Scott (Univesity of California, Davis, USA) "Cytoskeleton and nuclear division in Giardia" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Host Innate and Adaptive Immune Response |
| Discussion Leader: Elena Levashina (Institute of Molecular Biology, CNRS, Strasbourg) |
9:00 am - 9:20 am | Levashina, Elena (Institute of Molecular Biology, CNRS, Strasbourg) "Central role of complement in the mosquito responses against Plasmodium parasites" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Hunter, Christopher (University of Pennsylvania, Philadelphia, USA) "Imaging the immune response to Toxoplasma gondii" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Coffee Break |
10:15 am - 10:35 am | Zavala, Fidel (Johns Hopkins University, Baltimore, USA) "Homing and functional properties of liver-resident memory CD8+ T cells against malaria parasites" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Pays, Etienne (Université Libre de Bruxelles, Belgium) "Molecular dialogue between Trypanosoma brucei and its mammalian hosts" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Crompton, Peter (NIAID/NIH, USA) "New approaches to understanding the B cell response to malaria" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:30 pm | Short Talks |
11:45 am - 11:55 am | Fentress, Sarah (Washington University, USA) "Toxoplasma gondii ROP18 kinase thwarts host defenses by phosphorylating immunity- related GTPases" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Dzierszinski, Florence (McGill University, Canada) "Post-translational regulation of MHC-II antigen presentation by Toxoplasma gondii" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Raper, Jayne ( NYU School of Medicine, USA) "Antimicrobial HDL-the good cholesterol?" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Novel intervention strategies |
| Discussion Leader: Mike Ferguson (University of Dundee, UK) |
7:30 pm - 7:50 pm | Ferguson, Mike (University of Dundee, UK) "Protein glycosylation in Trypanosoma brucei: host-parasite differences and therapeutic opportunities" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Ward, Stephen (Liverpool School of Tropical Medicine, UK) "Targeting parasite uniqueness" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Kappe Stefan (Seattle Biomedical Research Institute, USA) "Live-attenuated whole-cell malaria vaccine design" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:30 pm | Short Talks |
9:00 pm - 9:10 pm | Malmquist, Nick (Institut Pasteur, France) "Targeting the epigenetic machinery of P. falciparum" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Istvan, Eva (Washington University, USA) "Plasmodium falciparum isoleucyl-tRNA synthetases" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |