SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Epigenetics, Chromatin Remodeling and Gene Regulation |
| Discussion Leader: Luisa Miranda Figueiredo (University of Lisbon, Portugal) |
7:40 pm - 8:00 pm | Luisa Miranda Figueiredo (University of Lisbon, Portugal)
"Chromatin Dynamics and Gene Expression in Trypanosoma brucei" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Jonathan Weitzman (University of Paris, France)
"Rewiring of Host Gene Regulation Networks by Theileria" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Till Voss (Swiss Tropical Institute, Basel Switzerland)
"Heterochromatic Protein 1 Regulates Antigenic Variation and Mitotic Proliferation in Malaria Blood Stage Parasites" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Metabolism and Sensing of Host Environment |
| Discussion Leader: Malcolm McConville (University of Melbourne, Australia) |
9:00 am - 9:20 am | Malcolm McConville (University of Melbourne, Australia)
"The Metabolic Adaptations of Intracellular Parasites" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Maria Mota (University of Lisbon, Portugal)
"Plasmodium Ability to Sense Changes in the Host" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Upi Singh (Stanford University, USA)
"Unusual Aspects of RNAi-Mediated Gene Silencing in the Protist Entamoeba histolytica" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Richard Grencis (University of Manchester, UK)
"Genes, Molecules and Cells in the Whipworm/Host Relationship" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Chris West (University of Oklahoma Health)
"The Role of Toxoplasma Skp1 Prolyl Hydroxylation and Glycosylation in Oxygen Sensing" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Anthony Szempruch (University of Georgia)
"Bloodstream for T. brucei Excellular Vesicles Mediate Intercellular and Host Interactions" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Mark Robinson (Queen's University, Belfast)
"Helminth Extracellular Vesicles: The Key to Parasite Control?" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Katherine Harker (University of California, Irvine)
"Shear Forces Enhance Toxoplasma gondii Tachyzoite Motility on Vascular Endothelium" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Organelles Biogenesis and Trafficking |
| Discussion Leader: Kasturi Haldar (University of Notre Dame, USA) |
7:30 pm - 7:50 pm | Kasturi Haldar (University of Notre Dame, USA)
"Host Remodeling by Malaria, in Virulence and Disease" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Boris Striepen (University of Georgia, USA)
"Apicoplast Biogenesis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Andre Schneider (University of Bern, Switzerland)
"How Do Trypanosomes Build Their Mitochondrion?" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Gang Dong (Max F. Perutz Laboratories, Austria)
"Structure and Assembly Mechanism of TbBILBO1 an Essential Protein for Formation of the Flagellar Collar of Trypanosoma brucei" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Alexandar Paredez (University of Washington)
"Rac Regulation of Membrane Trafficking in Giardia" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Parasite Persistence and Differentiation |
| Discussion Leader: Kent Hill (University of California Los Angeles, USA) |
9:00 am - 9:20 am | Kent Hill (University of California Los Angeles, USA)
"Flagellum Biology in the African Trypanosome, Trypanosoma brucei" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Rita Tewari (University of Nottingham, UK)
"A Functional Screen of the Plasmodium Phosphatome Reveals Key Regulators of Parasite Development and Differentiation" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Matthias Marti (Harvard School of Public Health, USA)
"Mechanisms of Gametocyte Formation and Sequestration in the Human Malaria Parasite, Plasmodium falciparum" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Maria Yazdanbakhsh (Leids Universitair Medisch Centrum, Netherlands)
"Immune Modulation by Parasitic Helminths: The TH2 and the Regulatory Network" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Dan Zilberstein (Technion-Israel Institute of Technology, Israel)
"Signaling Pathways Identified by Systems Analysis of Lesihmania Differentiation" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Tania De Koning-Ward (Deakin University, Australia)
"Functional Proof for the Role of PTEX in the Export of Diverse Protein Cargo" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Kristian Stodkilde-Jprgensen (Aarhus University - Denmark)
"Heme Piracy by Trypnosome Parasites" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Jun Liu (Indiana University Bloomington)
"The Regulation of the Organization and Function of Toxoplasma gondii Cortical Microtubule" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Therapeutic Interventions/Drugs and Drug Resistances |
| Discussion Leader: Meg Phillips (UT Southwestern Medical Center, USA) |
7:30 pm - 7:50 pm | Meg Phillips (UT Southwestern Medical Center, USA)
"Dihydroorotate Dehydrogenase Inhibitors for the Treatment of Malaria" |
7:50 pm - 8:00 pm | Discusion |
8:00 pm - 8:20 pm | Kip Guy (St. Jude Children's Research Hospital, USA)
"The Dihydroisoquinolones: Orally Available Antimalarials" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Marc Ouellette (Canadian Institutes of Health Research, Montreal, Canada)
"Functional Genomics and Drug Resistance Genes Discovery in Leishmania" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Shilpi Khare (Novartis (Genomics Institute))
"Trypanosoma cruzi Cytochrome B as a Chagas Disease Drug Target: Discovery of a Selective Inhibitor Blocking Parasite Growth" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Celia Miguel (GlaxoSmithKline - Spain)
"Plasmodium falciparum Female Gamete Formation as a Novel Target for High Throughput Screening in Malaria Drug Discovery" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Host Immune Defenses and Parasite Evasion |
| Discussion Leader: Edward Pearce (Washington University, USA) |
9:00 am - 9:20 am | Edward Pearce (Washington University, USA)
"The Role of Lipolysis in Alternative Macrophage Activation During Helminth Infection" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Annette MacLeod (University of Glasgow, UK)
"The Co-Evolutionary Arms Race Between Humans and African Trypanosomes" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Felix Yarovinsky (University of Texas Southwestern Medical Center, USA)
"Cell-Specific Regulation of Innate Immune Defense to Toxoplasma gondii" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Karine Le Roch (University of California Riverside)
"Three-Dimensional Modeling of the P. falciparum Genome During the Erythrocytic Cycle: A Major Organizational Role of Virulence Genes in the Genome Architecture"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Galadriel Hovel-Miner (Rockefeller University)
"Specific DNA Repeats Control the Frequency and Diversity of Surface Antigen Gene Selection in Trypanosoma brucei" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Rudo Kieft (University of Georgia)
"Trypanosoma brucei Rhodesiense Has Evolved Mechanisms to Avoid Human Adaptive and Innate Immunity" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Jason Pinger (The Rockefeller University)
"The Dynamics of VSG Coat Turnover During Antigenic Variation in African Trypanosomes" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Teresa Cristina Calegari Silva (Federal University of Rio de Janeiro, Brazil)
"NF-KappaB-Mediated Transcription Repression in Leishmania amazonensis Infection: Role of the Chromatin Remodeling Enzyme HDAC1" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Protein Structure and Vaccine Development |
| Discussion Leader: Simon Draper (University of Oxford, UK) |
7:30 pm - 7:50 pm | Simon Draper (University of Oxford, UK)
"Towards the Development of a Broadly-Neutralising Vaccine Against Blood-Stage Plasmodium falciparum" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Gavin Wright (Sanger Institute, UK)
"Identifying Extracellular Host-Pathogen Interactions Using Systematic Protein Interaction Screens" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Martin Boulanger (University of Victoria, Canada)
"Molecular Crosstalk Between Apicomplexan Parasite and Host Cell: Building a Model of Invasion" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Ajay Saxena (Jawaharlal Nehru University, India)
"Crystal Structure and Biochemical Analysis of P. falciparum Falstatin in Complex with Plasmodium Cysteine Proteases FP2 and FP3" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Hong You (QIMR Berghofer Medical Research, Australia)
"The Insulin Receptor: An Achilles' Heel for Schistosome Vaccine Development" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Invasion and Subversion of Host Functions |
| Discussion Leader: Isabelle Coppens (John Hopkins University, USA) |
9:00 am - 9:20 am | Isabelle Coppens (John Hopkins University, USA)
"Toxoplasma Auxotrophies: Discovery and Therapeutic Exploration" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Ali Hakimi (CNRS, Grenoble, France)
"Toxoplasma Exports a Novel Sub-Family of Dense Granule Proteins into the Host Cell Nucleus to Rewire the Host Genome Expression" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Volker Heussler (University of Bern, Switzerland)
"Two Sides of the Same Coin: Beneficial and Deleterious Effects of Host Cell Autophagy in Plasmodium-Infected Hepatocytes" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Christina Hull (University of Wisconsin, USA)
"When Sex is Hazardous to Your Health: Pathogenesis of Cryptococcus Spores" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Chun-Ti Chen (Boston College)
"Functional Dissection of the Toxoplasma gondii Mitotic Apparatus" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Aditya Paul (Harvard School of Public Health)
"Plasmodium calcineurin Regulates Attachment to Erythrocytes for Invasion by Parasites" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Jennifer Lumb (Stanford University)
"Systematic Identification of Genes Involved in IFN Gamma Signaling FP3" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | James Collins (University of Illinois/HHMI)
"Adult Somatic Stem Cells Rapidly Renew the Schistosome Host-Parasite Interface FP3" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Host/Parasite Co-Evolution |
| Discussion Leader: L. Aravind (NIH, USA) |
7:30 pm - 7:50 pm | L. Aravind (NIH, USA)
"Evolution of Strategies for Encoding Epigenetic Information in Eukaryotic Parasites" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Sven Gould (Heinrich-Heine-Universität,Düsseldorf, Germany)
"The Unique Biology of Trichomonas vaginalis Infection" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | TBA |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Philip McQueen (National Institutes of Health)
"Thalassemia Trait Erythrocytes Inhibit the Asexual Multiplication of Plasmodium falciparum In Vitro FP3" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Bridget Penman (University of Oxford, United Kingdom)
"Malaria Selects for Globin Gene Variation in the Long-Tailed Macaque FP3" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |