Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Pharma Partnerships in Parasitic Diseases |
| Discussion Leader: Meg Phillips (University of Texas Southwestern Medical Center, USA) |
7:40 pm - 7:45 pm | Introduction by Discussion Leader |
7:45 pm - 8:05 pm | Jeremy Burrows (Medicines for Malaria Venture, Switzerland) "The
Eradication Challenge: Discovering Next Generation Antimalarials" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Thierry Diagana (Novartis Institute for Tropical Diseases, Singapore) "Addressing Unmet Medical Need of the Developing World Through Collaborative Innovation" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Julio Martin (GlaxoSmithKline, Spain) "Discovery in Partnership at GSK: Molecules and Models to Combat Kinetoplastid Diseases" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Advancing New Therapies to Block Disease and Transmission |
| Discussion Leader: Kasturi Haldar (University of Notre Dame, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Meg Phillips (University of Texas Southwestern Medical Center, USA) "Targeting Malaria Dihydroorotate Dehydrogenase" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:15 am | Coffee Break |
10:15 am - 10:35 am | Ian Gilbert (University of Dundee, United Kingdom) "Novel Chemotherapy Against Malaria and Trypanosomes" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Elizabeth Winzeler (University of California, San Diego, USA) "Neglected Diseases Research at the Interface of Chemistry and Genetics" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Erika Flannery (Center for Infectious Disease Research, USA) "Testing Prophylactic and Radical Cure Activity of Drugs Against Liver-Stage Plasmodium vivax and Plasmodium falciparum in a Humanized Mouse Model" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Amitabha Mukhopadhyay (National Institute of Immunology, India) "Hemoglobin Receptor: A Novel Vaccine Candidate for Visceral Leishmaniasis" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Joey Verdi (Hunter College, City University of New York, USA) "Germline Transmission of Targeted Baboon Apolipoprotein L-I in Mice Protects Against African Trypanosomes" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Akhil Vaidya (Drexel University College of Medicine, USA) "Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in Cholesterol Content and Morphology of Plasmodium falciparum" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genomic/Genetic Regulation and Manipulation |
| Discussion Leader: David Sibley (Washington University in St. Louis, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Boris Striepen (University of Georgia, USA) "Genetic Analysis of the Diarrheal Pathogen Cryptosporidium" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | David Fidock (Columbia University, USA) "Recent Insights Into the Genetic Basis of Antimalarial Drug Resistance" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | James Collins (University of Texas Southwestern Medical Center, USA) "Functional Genomic Interrogation of Schistosome Stem Cells" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | YenYu Yang (College of Medicine, National Taiwan University, Taiwan) "Iron-Inducible Histone Modifications in Trichomonas vaginalis" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Josh Beck (Washington University School of Medicine in St. Louis, USA) "Interrogating PTEX Function in P. falciparum Protein Export with Emerging Functional Genetic Approaches" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Emerging Drug Resistance |
| Discussion Leader: Jeremy Burrows (Medicines for Malaria Venture, Switzerland) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Kasturi Haldar (University of Notre Dame, USA) "A Molecular Mechanism of Artemisinin Resistance in P. falciparum Malaria" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Arjen Dondorp (Mahidol Oxford Tropical Medicine Research Unit, Thailand) "The Subclinical Reservoir of Infection" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Leann Tilley (University of Melbourne, Australia) "Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Abdoulaye Djimde (University of Science, Techniques and Technologies of Bamako, Mali) "Molecular Determinants of P. falciparum Resistance to Artemisinins and Partenaire Drugs in Sub-Saharan Africa" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Gustavo Afanador (University of Texas Southwestern Medical Center, USA) "Functional Studies of Trypanosomatid Deoxyhypusine Synthase as Drug Target" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Marcus Lee (Wellcome Trust Sanger Institute, United Kingdom) "New Genetic Approaches to Accelerate Antimalarial Target Identification and Validation" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Miguel Morales (University of Notre Dame, USA) "Mechanisms of Miltefosine Resistance in Leishmania" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Judith Straimer (Columbia University, USA) "Impact of K13 Mutations on Parasite Fitness and Susceptibility to Ozonides" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Sensing and Signaling in Parasitism |
| Discussion Leader: Matthias Marti (Harvard T.H. Chan School of Public Health, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Martin Olivier (McGill University, Canada) "Nanobiome of Leishmanial Sand Fly Vector: Impact on Leishmaniasis Development" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Kenneth Stuart (Center for Infectious Disease Research, USA) "Drug Target Systems of Kinetoplastid" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Alok Bhattacharya (Jawaharlal Nehru University, India) "Mechanism of Phagocytosis in Entamoeba histolytica" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Crystal Cooper (University of Western Australia, Australia) "Host-Parasite Interactions Between Australian Marsupials and Trypanosoma spp." |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Julia Romano (Johns Hopkins University Bloomberg School of Public Health, USA) "Unraveling the Process of Nutrient Acquisition by Toxoplasma gondii" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biochemistry and Metabolism |
| Discussion Leader: Malcolm McConville (University of Melbourne, Australia) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Daniel Goldberg (Washington University School of Medicine in St. Louis, USA) "Plasmodium Effector Proteins" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Michael Barrett (University of Glasgow, United Kingdom) "Polyomic Approaches to Understanding Anti-Parasitic Drug Resistance" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Domique Soldati (University of Geneva Medical School, Switzerland) "Aspartiyl Proteases and Establishment of Parasitisim: Revisiting Old Drug Targets" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Audrey Odom (Washington University School of Medicine in St. Louis, USA) "The Smell of Success: Volatile Compounds in Malaria" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Eleanor Saunders (University of Melbourne, Australia) "Delineating the Essential Role of Glucose Uptake and Metabolism in Leishmania Infectivity" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Alassane Mbengue (University of Notre Dame, USA) "Malarial Phosphoinositide Detection in Virulence and Disease" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Laura-Isobel McCall (University of California, San Diego, USA) "Position, Parasites and Pathways: Untargeted Metabolomics, Molecular Networking and 3-D Modeling in an Acute Model of Chagas Disease" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Purnima Bhanot (Rutgers New Jersey Medical School, USA) "Invasion of Hepatocytes by Plasmodium Sporozoites Requires cGMP-Dependent Protein Kinase and Calcium Dependent Protein Kinase 1 and 4" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Immunity
and Persistence |
| Discussion Leader: Maria Mota (Instituto de Medicina Molecular, Portugal) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Nisha Garg (University of Texas Medical Branch, USA) "T. cruzi Manipulation of Macrophages: It Is Not All About Oxidative Burst" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Michael Hsieh (Biomedical Research Institute, Children's National Medical Center, USA) "Defining the Immunomodulatory Niche of Schistosome haematobium IPSE" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Dan Neafsey (Broad Institute of MIT and Harvard, USA) "Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Jeroen Saeij (University of California, Davis, USA) "Toxoplasma Inflammasome Activation" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Maria Ailen Natale (Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben", Argentina) "Chronically Trypanosoma cruzi Infected Subjects Lacking Parasite Specific T Responses Have Alterations in the IL7/IL7R Signalling Pathway" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Parasite Development, Differentiation and Transmission |
| Discussion Leader: Stephen Beverley (Washington University School of Medicine in St. Louis, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Flaminia Catteruccia (Harvard T.H. Chan School of Public Health, USA) "Natural Wolbachia Infections in Anopheles Populations: A New Factor in Malaria Transmission?" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Oliver Billker (Wellcome Trust Sanger Institute, United Kingdom) "Plasmodium berghei Genetics of Parasite-Host Interactions" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Nina Papavasiliou (Rockefeller University, USA) "VSG Coat Replacement and the Mechanisms of Immune Evasion in the African Trypanosome" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | David Sacks (National Institute of Allergy and Infectious Diseases, NIH, USA) "The Biology of Mating in Leishmania" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Ellen Yeh (Stanford University, USA) "An Anti-Malarial Compound with a Novel Mechanism-of-Action Targeting Apicoplast Biogenesis" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Tania Rozario (University of Illinois at Urbana-Champaign, USA) "Characterization of the Growth and Regenerative Potential of the Rat Intestinal Tapeworm, Hymenolepis diminuta, Cultured In Vitro" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Karine Frenal (University of Geneva, Switzerland) "Disruption of TgUNC Uncovers the Phenome of Toxoplasma gondii Myosin and a Unique Role of TgMyoI in Cell-to-Cell Communication" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Philipp Olias (Washington University School of Medicine, USA) "Toxoplasma Inhibitor of STAT Transcription TgIST Associates with the Mi2/NuRD Complex and Blocks Interferon Signaling Pathways" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Targets in Host Entry and Remodeling |
| Discussion Leader: John Boothroyd (Stanford University School of Medince, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Manoj Duraisingh (Harvard T.H. Chan School of Public Health, USA) "The Identification and Targeting of Red Blood Cell Determinants of Malaria Infection" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Stefan Kappe (Center for Infectious Disease Research, USA) "Host Cell-Parasite Interactions as Targets for Prevention of Malaria Infection" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Luisa Figueiredo (Instituto de Medicina Molecular, Portugal) "Trypanosoma brucei: A New Life Beyond the Bloodstream" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Agata Zerka (Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Poland) "Glycophorin D Homolog Is the Ancestral Receptor for Plasmodium reichenowi EBA-140 Merozoite Ligand on Chimpanzee Erythrocytes" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Jason Pinger (Rockefeller University, USA) "VSG Coat Replacement: Dynamics of the Host-Pathogen Interface During T. brucei Infection" |
9:25 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |