Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Global Impact of Parasitic Pathogens on Human Health
Discussion Leader: David Fidock (Columbia University Medical Center, USA)
7:40 pm - 8:10 pm
Jeremy Burrows (Medicines for Malaria Venture, Switzerland)
"Challenges and Successes: Discovering New Antimalarial Treatments and Chemoprotectants"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Annette MacLeod (University of Glasgow, United Kingdom)
"The Skin: An Overlooked Reservoir of African Trypanosomes"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Rick Tarleton (University of Georgia, USA)
"Developing Solutions for Chagas Disease: The Importance of Understanding Parasite Biology"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome and Genes, Expression and Regulation
Discussion Leader: T. Nicolai Siegel (Ludwig-Maximilians-Universität München, Germany)
9:00 am - 9:20 am
Artur Scherf (Institut Pasteur, France)
"Malaria Parasite DNA Modifications Revisited"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
David Sibley (Washington University, USA)
"Manipulaiton of Host Gene Expression and Signaling by Toxoplasma"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Tania Rozario (Morgridge Institute for Research, University of Wisconsin-Madison, USA)
"Hymenolepis Diminuta as a Parasite Model for Stem Cells and Regeneration"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
James Collins (University of Texas Southwestern Medical Center, USA)
"The Parasitic Love Machine: Understanding Schistosome Sexual Reproduction on a Molecular Level"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Upinder Singh (Stanford University, USA)
"Metabolic Changes, Transcriptional Control and Regulation of Stage Conversion in Entamoeba histolytica : Linking It All Together"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
David Roos (University of Pennsylvania, USA)
"Integrating and Interrogating Big (Pathogen) Datasets from the Lab, Field and Clinic"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Vasant Muralidharan (University of Georgia, USA)
"An ER-Resident Calcium Binding Protein Is Required for Egress and Invasion of Malaria Parasites"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Ellen Yeh (Stanford University, USA)
"1 + 1 = 1: A Forward Screen for Novel Plastid Biogenesis Genes in Malaria Parasites"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: F. Nina Papavasiliou (German Cancer Research Center, Germany) and Jayne Raper (Hunter College, City University of New York, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Pathogenesis and Host Cell Remodeling
Discussion Leader: Manoj Duraisingh (Harvard T.H. Chan School of Public Health, USA)
7:30 pm - 7:50 pm
Patricia Johnson (University of California, Los Angeles, USA)
"Trichomonas vaginalis Pathogenesis: Surface and Secreted Factors"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Barbara Burleigh (Harvard T.H. Chan School of Public Health, USA)
"Exploring Metabolic Flexibility and Adaptation in Intracellular Trypanosoma cruzi Amastigotes"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Alan Cowman (Walter and Eliza Hall Institute of Medical Research, Australia)
"Moving in and Renovating: Invasion and Remodeling of the Human Erythrocyte by the Malaria Parasite"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Chi-Min Ho (UCLA Molecular Biology Institute, USA)
"CryoEM Reveals Translocation Mechanism in Malaria Parasite Effector Export"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Michael Reese (University of Texas Southwestern Medical Center, USA)
"A Divergent Secreted Kinase Regulates Membrane Ultrastructure of the Toxoplasma Parasitophorous Vacuole"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Antigenic Variation
Discussion Leader: F. Nina Papavasiliou (German Cancer Research Center, Germany)
9:00 am - 9:20 am
Kirk Deitsch (Weill Cornell Medicine, USA)
"Coordinated Expression of Multi-Copy Gene Families in the Human Malaria Parasite Plasmodium falciparum "
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Joe Smith (Center for Infectious Disease Research, USA)
"Understanding Mechanisms of Cerebral Malaria Pathogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Anna Barcons-Simon (Institut Pasteur, France)
"A GC-Rich Non-Coding RNA Acts as Trans-Activator of Monoallelic Expression in Plasmodium falciparum "
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
C. Erec Stebbins (German Cancer Research Center (DKFZ), Germany)
"The Increasing 'Diversity-Space' of Trypanosoma brucei Antigenic Variation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Monica Mugnier (Johns Hopkins Bloomberg School of Public Health, USA)
"Exploring the Dynamics of Antigenic Variation and VSG Diversification in the T. brucei Extravascular Niche"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
David Horn (University of Dundee, United Kingdom)
"A VSG Allelic Exclusion Complex"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Manuel Saldivia Concepción (University of York, United Kingdom)
"Divide et Impera : Chromosome Segregation in Trypanosoma brucei , a Target Deconvolution View"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Michael Wells (Johns Hopkins University, USA)
"Plasmodium berghei Sporozoite Infection of Anopheles stephensi Salivary Glands"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunity and Vaccines
Discussion Leader: Kim Williamson (Uniformed Services University of the Health Sciences, USA)
7:30 pm - 7:50 pm
Miguel Prudencio (Instituto de Medicina Molecular, Portugal)
"Clinical Evaluation of a New Vaccine Against Malaria"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Stephen Beverley (Washington University School of Medicine in St. Louis, USA)
"An Essential Mitochondrial Fucosyl Transferase in Leishmania "
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Klaus Brehm (University of Wuerzburg, Germany)
"How Cancerous Tapeworms Work"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Anita Koshy (University of Arizona, USA)
"Neuronal Defense Mechanisms Against Toxoplasma gondii Infection"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Nicolas Cermakian (McGill University, Canada)
"The Circadian Clock in Immune Cells Controls the Magnitude of Leishmania Parasite Infection"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Vulnerabilities and Impact on Life Cycle
Discussion Leader: Sean Prigge (Johns Hopkins Bloomberg School of Public Health, USA)
9:00 am - 9:20 am
Michael Barrett (University of Glasgow, United Kingdom)
"Metabolic Vulnerability of Parasites Probed Through Exposure to Drugs"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Maria Lafuente (GlaxoSmithKline, Spain)
"Exploiting Phenotypic Hits to Discover P. falciparum Weaknesses"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Russell Swift (Johns Hopkins School of Public Health, USA)
"Pyruvate Kinase II Is Required for Apicoplast Maintenance"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Brian Mantilla (Center for Tropical and Emerging Global Diseases, University of Georgia, USA)
"InsP7 Protein Targets Reveal Distinct Roles in Proliferative Stages of Trypanosoma cruzi "
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Geoffrey McFadden (University of Melbourne, Australia)
"Can We Build a Genetic Trap for Drug Resistant Malaria Parasites?"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Sebastian Lourido (Whitehead Institute, Massachusetts Institute of Technology, USA)
"Systems Approaches to Uncover Mechanisms of Drug Resistance in Apicomplexan Parasites"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Vanessa Zuzarte-Luis (Instituto de Medicina Molecular, University of Lisbon, Portugal)
"Diet-Induced Oxidative Stress Impair Plasmodium Liver Infection"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Veronica Jimenez (California State University, Fullerton, USA)
"Mechanosensation in Trypanosomes: Physical Cues to Sense the World Around Them"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Parasite and Host Cell Communication
Discussion Leader: Isabel Roditi (University of Bern, Switzerland)
7:30 pm - 7:50 pm
Kent Hill (University of California, Los Angeles, USA)
"Cell-Cell Communication in Trypanosoma brucei "
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Elissa Hallem (University of California, Los Angeles, USA)
"Host-Seeking Behaviors of Parasitic Nematodes"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Katherine Ralston (University of California, Davis, USA)
"Entamoeba histolytica Trogocytosis and Protection from Innate Immune Factors"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Sarah Ewald (University of Virginia, USA)
"Understanding Cachexia Through Host-Parasite Interactions"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Filipa Rijo-Ferreira (University of Texas Southwestern Medical Center, USA)
"Sleeping Sickness Is a Circadian Disorder"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Drug Development
Discussion Leader: Elizabeth Winzeler (University of California, San Diego, USA)
9:00 am - 9:20 am
Kelly Chibale (University of Cape Town, South Africa)
"Exploiting the Host Haemoglobin Degradation Pathway for Malaria and Schistosomiasis Drug Discovery"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Leah Frye (Schrödinger, USA)
"Computational Approaches to Accelerate Drug Discovery"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Stacie S. Canan (Celgene Global Health, USA)
"Data Visualization and Analysis to Empower Antimalarial Drug Discovery"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Lilach Sheiner (University of Glasgow, United Kingdom)
"Redox Controlled Functions of Apicomplexan Parasites"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Paul Wyatt (University of Dundee, United Kingdom)
"Identifying Novel Targets Through Phenotypic Screening"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Thierry Diagana (Novartis Institute for Tropical Diseases, U.S. Minor Outlying Islands)
"Drug Discovery and Early Development for Protozoan Parasitic Diseases Therapeutics"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Case McNamara (California Institute for Biomedical Research, USA)
"Identification of Anti-Wolbachial Compounds to Cure Parasitic Worm Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Paul Sigala (University of Utah School of Medicine, USA)
"Doxycycline Has Distinct Apicoplast-Specific Mechanisms of Antimalarial Activity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Challenges to Effective Therapy
Discussion Leader: Nicole Andenmatten (Medicines for Malaria Venture, Switzerland)
7:30 pm - 7:50 pm
Jayne Raper (Hunter College, City University of New York, USA)
"The Arms Race Between Host and Parasite: Serum Resistance in Zoonotic Trypanosomes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Pradipsinh Rathod (University of Washington, USA)
"Mutagenesis in Plasmodium falciparum "
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Dyann Wirth (Harvard T.H. Chan School of Public Health, USA)
"Harnessing Genomics for Understanding Malaria Drug Resistance"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
David Fidock (Columbia University Medical Center, USA)
"Emerging Southeast Asian PfCRT Mutations Confer P. falciparum Resistance to the First-Line Antimalarial Piperaquine"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Thomas Wellems (National Institute of Allergy and Infectious Diseases, NIH, USA)
"K13 C580Y Mutation Is Not Linked to Increased Artemisinin Treatment Failures in a P. falciparum Cross"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure