| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Evolution and Diversity |
| Daniel Dykhuizen, Discussion Leader (SUNY, Stony Brook, NY)
Introduction |
| George Weinstock (Baylor College of Medicine, Houston, TX)
"Comparative genomics of Treponema" |
| Alan Barbour (Univ. California, Irvine, CA)
"Programmed Evolution of Vsp/Vlp Proteins of Relapsing Fever Borrelia" |
| Thad Stanton (Natl. Animal Disease Ctr., Ames, IA)
"The Ins and Outs of VSH-1, a Novel Gene Transfer Agent of Brachyspira hyodysenteriae" |
| Ulf Gobel (Humboldt Universitat, Berlin, Germany)
"Toll-like receptors and induction of innate immunity in spirochete infections" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Gene Organization, Expression, and Function |
| Patricia Rosa, Discussion Leader (RML, NIAID, NIH, Hamilton, MT)
Introduction |
| Howard Kuramitsu (SUNY, Buffalo, NY)
"Heterologous cloning in T. denticola" |
| Mathieu Picardeau (Institut Pasteur, Paris, France)
"Genetic manipulation of Leptospira" |
| Kit Tilly (RML, NIAID, NIH, Hamilton, MT)
"Transformation studies of Borrelia burgdorferi" |
| Brian Stevenson (Univ. of Kentucky, Lexington, KY)
"Regulation of gene expression in Borrelia" |
| Xiaofeng Yang (Univ. of Texas, Dallas, TX)
"Regulatory networks in Borrelia burgdorferi"
|
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Genomic and Proteomic Analysis |
| Steve Norris, Discussion Leader (Univ. Texas, Houston, TX)
Introduction |
| Sherwood Casjens (Univ. of Utah, Salt Lake City, UT)
"Comparative genomics of Borrelia" |
| George Chaconas (Univ. of Western Ontario, London, Ont., Canada)
"Telomer resolution in Borrelia: Molecular details and reaction mechanisms" |
| Timothy Palzkill (Baylor College of Medicine, Houston, TX)
"Cloning and expressing the Treponema pallidum proteome" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Host Parasite Interactions I: Attachment |
| Magnus Höök, Discussion Leader (Texas A&M Univ., Houston, TX)
Introduction |
| Lari Hakkinen (Univ. British Columbia, Vancouver, Canada)
"Fibronectin, integrins, and decorin in periodontal tissues" |
| Barbara Johnson (NCID, CDC, Fort Collins, CO)
"Does fibronectin-binding lead to cell invasion by B. burgdorferi?" |
| Jenifer Coburn (Tufts Univ. Boston, MA)
"Attachment of Borrelia to host tissue" |
| Caroline Cameron (Univ. Washington, Seattle, WA)
"Adhesins of Treponema pallidum" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Host-Parasite Interactions II:
Inflammation and Cell:Cell Interactions |
| Justin Radolf, Discussion Leader (Univ. Connecticut, Farmington, CT)
Introduction |
| Chris Overall (Univ. British Columbia, Vancouver, Canada)
"Metalloproteases and the development of inflammation" |
| Martha Furie (SUNY, Stony Brook, NY)
"Interactions between Borrelia and endothelial cells"
|
| Mark Wooten (Medical College of Ohio, Toledo, OH)
"Innate immunity and Borrelia infections in mice" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Antigens and Host Response |
| Mike Lovett, Discussion Leader (UCLA, Los Angeles, CA)
Introduction |
| Linda Bockenstedt (Yale Univ., New Haven, CT)
"CD1d and modulation of lipoprotein-induced inflammation" |
| Brigitte Huber (Tufts Univ., Boston, MA)
"Molecular mimicry by OspA and its role in arthritis" |
| James Matsunaga (VA Medical Center, Los Angeles, CA)
"Variable expression of Leptospira proteins" |
| Christiane Heimerl (Ludwig Maximilians Universitat, Munich, Germany)
"Actin skeleton rearrangements during coiling phagocytosis" |
| Richard Ellen (Univ. Toronto, Toronto, Canada)
"Treponema denticola Msp perturbation of actin dynamics that affect store-operated calcium flux" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Biology, Physiology, Structure and Ecology |
| Bettina Wilske, Discussion Leader (Max von Pettenkofer-Institut, Munich, Germany)
Introduction |
| Peter Greenberg (Univ. Iowa, Iowa City, IA)
"Quorum sensing in bacteria" |
| Nyles Charon (West Virginia Univ., Morgantown, WV)
"Genetic manipulation of motility genes" |
| Frank Gherardini (Univ. Georgia, Athens, GA)
"Spirochete Physiology" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Spirochetal Membranes and Membrane Proteins |
| Sheila Lukehart, Discussion Leader (Univ. Washington, Seattle, WA)
Introduction |
| Tom Schwan (RML, NIAID, NIH, Hamilton, MT)
"Biological Transmission, Infection, and Protein Synthesis of Borrelia Species in Ticks" |
| Arturo Centurion-Lara (Univ. Washington, Seattle, WA)
"Analysis of tprK alleles in treponemal isolates" |
| Richard Marconi (Medical Coll. of Virginia, Richmond, VA)
"Recombination of Borrelia OMP genes" |
| Christoph Eicken (Texas A&M, Houston,TX)
"Structure of the variable surface antigen VlsE1 of Borrelia burgdorferi" |
| Catherine Lawson (Rutgers Univ., Piscataway, NJ)
"Comparative structural analysis of Borrelia outer surface proteins" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Late Breaking Session and Microarray Roundtable |
| Kit Tilly (RML, NIAID, NIH, Hamilton, MT)
Wes Van Vooris (Univ. Washington, Seattle, WA)
Discussion Leaders |
| Short Talks: |
| Jun Ohnishi (Univ. North Carolina, Chapel Hill, NC)
Analysis of genetic diversity and expression pattern of Borrelia burgdorferi vlsE at each stage of a complete transmission cycle |
| Alyson Yoder (University of Utah, Salt Lake City, UT)
Macrophages from TLR2-deficient mice reveal responsiveness to non-lipoprotein ligands of Borrelia burgdorferi |
| Cecila Morgan (Univ. Washington, Seattle, WA)
T Cell Responses are Directed to the Conserved Regions of the Treponema pallidum Repeat Protein K while Antibody Responses are Directed to the Discrete Hyper-variable Regions |
| Matthew Lawrenz (Univ. Texas, Houston, TX)
Plasmid content determines the ability to transform Borrelia burgdorferi |
| Jankiram Seshu (Texas A&M Univ., Houston, TX)
Alterations in gene expression in Borrelia burgdorferi in response to varying levels of dissolved oxygen |
| Ranjit Deka (Univ. Texas, Dallas, TX)
X-ray crystallography of the Treponema pallidum 47-kilodalton lipoprotein (Tp47) reveals a new class of penicillin-binding protein |
| Microarray Presentations and Roundtable Discussion: |
| Chad Brooks (Univ. Oklahoma, Oklahoma City, OK) |
| Caroline Ojaimi (New York Medical College, New York, NY) |
| Andrew Revel (Univ. Texas, Dallas, TX) |
| Jianmin Zhong (Univ. California, Irvine, CA) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
