SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | GENE EXPRESSION AND DIVERSITY IN SPIROCHETES |
7:40 pm - 7:50 pm | Discussion Leader: Brian Stevenson (University of Kentucky, Lexington, KY) |
7:50 pm - 8:20 pm | Jeffrey Miller (UCLA, Los Angeles, CA) "Bacterial tropism switching mediated by diversity-generating retroelements" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Lorenzo Giacani (University of Washington, Seattle, WA) "Mechanisms of transcriptional regulation of the tpr genes of T. pallidum subsp. pallidum" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Ira Schwarz (New York Medical College, Valhalla, NY) "Transcriptional profiling of Borrelia burgdorferi" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BIOLOGY RELATED TO RISK FOR INFECTION |
9:00 am - 9:10 am | Discussion Leader: Richard Zuerner (National Animal Disease Center Ames, IA) |
9:10 am - 9:50 am | Sarah Randolph (University of Oxford, Oxford UK) "Climate change and emerging infection" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Joseph Vinetz (University of California San Diego School of Medicine, San Diego, CA) "Global impact of Leptospirosis" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:30 am | Coffee Break / Group Photo (11:15 am) |
11:30 am - 11:50 am | Maria Diuk-Wasser (Yale School of Medicine New Haven, CT, USA) "Evolutionary ecology of B. burgdorferi" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Jean-François Trapé (Institut de Recherche pour le Developpement, Dakar, Senegal) "Risk factors for relapsing fever in Africa" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | INVASION and EVASION STRATEGIES of SPIROCHETAL PATHOGENS |
| Discussion Leader: Barbara J. B. Johnson (CDC, Fort Collins, CO) |
7:30 pm - 7:50 pm | Jorge Benach (Stony Brook University, Stony Brook, NY) "Regulation of Borrelia burgdorferi penetration and host-inflammatory response" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Kazuyuki Ishihara (Tokyo Dental College, Chiba, Japan) "Protease activity and the invasion/ systemic dissemination of T. denticola" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Jennifer C. Miller (University of Utah, Salt Lake City UT) "A novel role for Type I IFN in Lyme arthritis" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Caroline Cameron (University of Victoria, BC, Canada) "Insight into the process of Treponema pallidum dissemination" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SPIROCHETAL TRANSPORT, ENVIRONMENTAL SIGNALS and METABOLISM |
9:00 am - 9:10 am | Discussion Leader: Wolfram Zueckert (Univ of Kansas; Kansas City, KS) |
9:10 am - 9:30 am | Frank Gherardini (Rocky Mountain Labs NIAID, Hamilton, MT) "Redox and oxidatative stress in B. burgdorferi" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Felipe Cabello (New York Medical College, Valhalla, NY) "Regulation of growth in Borrelia burgdorferi" |
10:00 am - 10:10 am | Discussion |
10:10 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Jacques Izard (The Forsyth Institute, Boston, MA) "Cytoskeleton of treponemes" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Janakiram Seshu (The University of Texas at San Antonio, TX) "Oxygen stress regulation in B. burgdorferi" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Juan Anguita (University of Massachusetts at Amherst. Amherst, MA) "Pathways of Borrelia burgdorferi-mediated cardiac inflammation" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Past Chairs' Forum: Conceptual Leaps Forward, Spirochetal Research in the 21st Century |
| This is a special forum in which past chairs of the GRC will debate theoretical biology that will impact future directions in research. The session is intended to provoke debate and discussion among GRC participants. |
7:30 pm - 7:40 pm | Discussion Leader: Ben Adler (Monash Univ., Melbourne, Australia) |
| Nyles Charon: Spirochetal motility |
| Alan Barbour: Borrelia, genetic diversity |
| Steve Norris: Comparative genomic/proteomic analysis |
| Sheila Lukehart: Treponema, protein diversity, infectivity |
| Janis Weiss: Disease models and immunity |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SPIROCHETE BIOLOGY & DIVERSITY |
9:00 am - 9:10 am | Discussion Leader: Annette Moter (Charité University Medicine, Berlin, Germany) |
9:10 am - 9:30 am | MA Motaleb (West Virginia University, Morgantown, WV) "Motility and chemotaxis of Borrelia burgdorferi, the Lyme disease spirochete" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Tom Schwan (Rocky Mountain Labs NIAID, Hamilton, MT) "Relapsing fever infection biology" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Cathrine Brissette (University of Kentucky, Lexington, KY USA) "Innate immunity resistance of Treponema denticola" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Betty Guo (Umeå University, Umeå, Sweden) "Relapsing fever Borrelia blood cell interaction" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | James Carroll (University of Pittsburgh School of Medicine, Pittsburgh, PA) "Proteome analysis of B. burgdorferi" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | INTERACTION WITH HOST CELLS, IMMUNOPATHOLOGY |
7:30 pm - 7:40 pm | Discussion Leader: Linda Bockenstedt (Yale University, New Haven, CT) |
7:40 pm - 8:00 pm | Mario Philipp (Tulane National Primate Research Center, Tulane University, LA) "Glial cells and neurons in the pathogenesis of Lyme neuroborreliosis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Ruth Montgomery (Yale University, New Haven, CT) "Recruitment of macrophages in Lyme carditis" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Allen Steere (Harvard Medical School, Boston, MA) "Clinical and immunological aspects on Lyme borreliosis" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion: Spirochete diversity and interaction with host cells/immune systems |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ADVANCES IN GENOMES, GENETICS, BIOLOGICAL PARADIGMS |
9:00 am - 9:10 am | Discussion Leader: Sherwood Casjens (University of Utah Medical Center) |
9:10 am - 9:30 am | Patricia Rosa (Rocky Mountain Labs NIAID, Hamilton, MT) "The role of plasmids in the B. burgdorferi life cycle" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Floyd Dewhirst (The Forsyth Insitute, Boston, MA,) "Genome sequence and deduced biology of Treponema lecithinolyticum" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Justin Radolf (University of Connecticut Health Center, CT) "The Quest for Treponema pallidum Outer Membrane Proteins: A Reappraisal" |
10:30 am - 10:40 am | Discussion |
10:40 am - 11:10 am | Coffee Break |
11:10 pm - 11:30 pm | George Chaconas (University of Calgary, Canada) "Studies on B. burgdorferi antigenic variation and studies on adhesion to and escape from the vasculature of a living host by real-time high resolution 3D imaging" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | David Haake (UCLA Los Angeles, CA) "From the Environment to the Host - Lives of a Leptospiral Pathogen" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion: Genome, genetics and biology |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | LATE BREAKING SESSION |
| Speaker and Titles (Selected from submitted abstracts) |
| Discussion Leaders: Kit Tilly (Rocky Mountain Labs., Hamilton MT) and Jenifer Coburn (Tufts Univ., Boston, MA) |
7:30 pm - 7:40 pm | X Frank Yang (University of Indiana, Indianapolis, IN) "Abrogation of OspA constitutively activates the RpoN-RpoS regulatory network of Borrelia burgdorferi" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Gerald L Murray (Monash University, Monashj, Australia) "Transposon mutagenesis of Leptospira interrogans identifies an attenuated lipopolysaccharide mutant" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Michael Matthias (University of California, San Diego, California) "Human Leptospirosis Caused by a New, Antigenically Unique Leptospira Associated with a Rodent Reservoir in the Peruvian Amazon" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Loic Coutte (University of Texas Medical School at Houston, Houston, Texas) "Analysis of the Borrelia burgdorferi B31 vlsE genetic recombination during mouse infection" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Teresa Francescutti (University of Victoria, Victoria, Canada) "Heterologous expression of the Treponema pallidum laminin-binding adhesin Tp0751 in the culturable spirochete Treponema phagedenis" |
8:40 pm- 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Howard F. Jenkinson (University of Bristol, UK) "A family of Treponema denticola fibronectin-interacting proteins interfacing bacterial cell surface function with host extracellular matrix" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Marco A. Magalhães (University of Toronto, Toronto, Canada) "The major outer sheath protein of Treponema denticola selectively inhibits Rac1 activation in murine neutrophils" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Robert Fischer (Rocky Mountain Labs NIAID, Hamilton, MT) "Purine Salvage by Borrelia hermsii in the Mammalian Host Environment" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |