| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Evolution and Immune Evasion in Spirochete Infections |
| Discussion Leader: Linden Hu (Tufts Medical Center) |
| 7:40 pm - 8:30 pm | Steve Norris (University of Texas Houston Medical Center)
"The Accidental Tourist: Spirochetes and the Evolution of Pathogenesis"
|
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:00 pm | Sheila Lukehart (University of Washington, Seattle)
"Antigenic Variation and Diversity in Treponema pallidum"
|
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:20 pm | Daniel Miller (Virginia Commonwealth University)
"Complement Evasion Strategies of Oral Treponemes Associated with Periodontal Disease"
|
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Interactions of Spirochetes with the Host |
| Discussion Leader: John Leong (Tufts Medical Center) |
| 9:00 am - 9:20 am | Angela Barbosa (University of Sao Paulo)
"Interaction of Pathogenic Leptospira with Complement Regulators as a Strategy to Evade the Host Innate Immune Response"
|
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Jenifer Coburn (Medical College of Wisconsin)
"Manipulation of the Host by Borrelia burgdorferi Adhesins"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | David Haake (VA Greater Los Angeles Healthcare System, UCLA)
"Numerous Host-Ligand Binding Proteins of Leptospira, Why Such Redundancy?"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Caroline Cameron (University of Victoria)
"Treponema pallidum-Host Interactions; Role in Bacterial Dissemination"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Alexia Belperron (Yale University)
"Using Optical Tweezers and Intravital Imaging to Better Understand the Secret Life of Spirochetes Within the Mammalian Host"
|
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Allison James (Washington State University)
"Investigating the DNA Elements Required for Antigenic Variation in Borrelia hermsii"
|
| 12:10 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Genomics and Genetic Manipulation in Spirochetes - What's New? |
| Discussion Leader: Scott Samuels (University of Montana) |
| 7:30 pm - 7:50 pm | Mathieu Picardeau (Institut Pasteur)
"Improving the Genetic Toolbox for Manipulation of Pathogenic Leptospira"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Chris Li (State University of New York at Buffalo)
"New Genetic Methods Facilitate Investigation of the Function of the Treponema pallidum Thiamine Transporter in the Oral Spirochete Treponema denticola"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Chris Fenno (University of MIchigan)
"Treponomics: Enhanced Tools for Genetic Manipulation in Spirochetes" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | Joe Vinetz (University of California, San Diego)
"Comparative Genomic Analysis of the 20 Species of Leptospira"
|
| 9:10 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:30 pm | General Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Innate and Adaptive Immune Responses in Spirochete Infections |
| Discussion Leader: Tim Sellati (Trudeau Institute) |
| 9:00 am - 9:20 am | Kishore Alugupalli (Thomas Jefferson University)
"Role of Toll-Like Receptors in Innate and B Cell Memory Responses to Borrelia hermsii"
|
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Mary Petzke (New York Medical College)
"Directing the Directors: The Role of Dendritic Cells in Borrelia burgdorferi Pathogenesis"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Linda Bockenstedt (Yale University)
"Fibrocartilage Defense Against Borrelia burgdorferi"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Janis Weis (University of Utah)
"Multiple Approaches Identify Type I Interferon in the Pathogenesis of Lyme Arthritis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Lourdes Isaac (University of Sao Paulo)
"Leptospiral Immunoglobulin-Like Proteins Interact with Plasminogen to Escape Complement Mediated-Killing"
|
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:00 pm | Priya Jayaraman (North Carolina State University)
"Modulation of Leptospira interrogans Infection by the Adaptor TRIF"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Chemotaxis and Motility in Spirochete Biology and Pathogenesis |
| Discussion Leader: Nyles Charon (West Virginia University) |
| 7:30 pm - 7:50 pm | Michael Miller (West Virginia University)
"Protein-Protein Covalent Binding and Treponema Motility"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Charles Wolgemuth (University of Arizona)
"The Motility of Borrelia burgdorferi: Moving from Liquid Media Toward Pathogen-Host Interactions"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Elsio Wunder (Yale University)
"Leptospiral Motility: Behind the Scenes"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Ambroise Lambert (Institut Pasteur)
"Characterization of a Chemotaxis Locus in Leptospira Involved in Motility and Virulence"
|
| 9:10 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:30 pm | General Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Linking the Outside with the Inside: Environmental Sensing and Gene Regulation |
| Discussion Leader: Brian Stevenson (University of Kentucky) |
| 9:00 am - 9:20 am | Daniel Miller (Virginia Commonwealth University)
"Molecular Signalling Mechanisms of the Periopathogen, Treponema denticola"
|
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Melissa Caimano (University of Connecticut Health Center)
"Environmental Sensing by Borrelia burgdorferi: How the Lyme Disease Spirochete Knows Whether It's Coming or Going"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Frank Yang (Indiana University)
"Interplay Between the Two Component Systems Hk2-Rrp2 and Hk1-Rrp1 of Borrelia burgdorferi"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Jarlath Nally (University College Dublin)
"Molecular Adaptions of Pathogenic Leptospires in Response to Mammalian Host Signals"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Lorenzo Giacani (University of Washington, Seattle)
"Treponema pallidum Subsp. Pallidum Sigma Factors and Pathogenesis of Syphilis"
|
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:00 pm | Meghan Lybecker (University of Vienna)
"The Small RNA Transcriptome of Borrelia burgdorferi"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Spirochete Surfaces and Structure |
| Discussion Leader: Catherine Brissette (University of North Dakota) |
| 7:30 pm - 7:50 pm | Darrin Akins (Oklahoma Health Sciences Center)
"Role of the Borrelia burgdorferi Beta-Barrel Assembly Machine (BAM) Complex in Outer Membrane Protein Export"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Alexander Dowdell (University of Kansas Medical Center)
"It's a Jungle Out There!: Spatial Characterization of the Borrelia burgdorferi Lipoproteome"
|
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:40 pm | Jun Liu (University of Texas Houston Health Science Center at Houston)
"High-Thoughput Cryo-Electron Tomography of Spirochetes: From Cells to Molecules"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | Ranjit Deka (University of Texas Southwestern Medical Center)
"Structure-Function Relationships of Treponema pallidum Lipoproteins"
|
| 9:10 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:30 pm | General Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Environmental, Ecological and Genetic Facets of Spirochete Infections |
| Discussion Leader: Alan Barbour (University of California Irvine) |
| 9:00 am - 9:20 am | Jared Leadbetter (California Institute of Technology)
"New Insights into the Physiology of Termite Gut Spirochetes"
|
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Sven Bergstrom (Umea University)
"Molecular Pathogenesis of Malaria and Relapsing Fever Borrelia Concomitant Infections"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:40 am | Radha Iyer (New York Medical College)
"Analysis of the Borrelia burgdorferi Transcriptome in Feeding Ticks and DMCs Reveals Unique Tick and Mammalian Phase Expression Profiles"
|
| 10:40 am - 10:50 am | Discussion |
| 10:50 am - 11:10 am | Erol Fikrig (Yale University)
"The Influence of Tick Gut Microbiota on Borrelia burgdorferi"
|
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:40 am | Job Lopez (Mississippi State University)
"Transmission and Dissemination of Borrelia turicatae" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:00 pm | Daniel Dulebohn (Rocky Mountain Laboratories)
"Defining the Acetate Pathway in Borrelia burgdorferi"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:20 pm | Tara Reid (University of Washington, Seattle)
"TprK Immune-Escape Variants Cause Lesions in Secondary Syphilis"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Host-Pathogen Interactions in Spirochetes Infections |
| Discussion Leader: Richard Zuerner (Sweden Veterinary and Agricultural University) |
| 7:30 pm - 7:50 pm | Jenny Hyde (Texas A&M Health Science Center)
"Characterization of Borrelia burgdorferi Temporal and Spatial Gene Expression During Experimental Infection"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Simon Houston (University of Victoria)
"The Role of Tp0750 in Treponema pallidum-Mediated Fibrinolysis and Extracellular Matrix Component Degradation"
|
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:30 pm | Yi-Pin Lin (Tufts Medical Center)
"The Borrelia burgdorferi Adhesin DbpA Binds the Host Complement Regulatory Protein C4BP to Promote Bloodstream Survival"
|
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:50 pm | Erin Troy (Tufts Medical Center)
"Using Massively Parallel Sequencing to Uncover the Role of Carbon Availability in Borrelia burgdorferi Virulence"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Patti Rosa (Rocky Mountain Laboratories)
"Molecular Genetic Investigation of Virulence Determinants of Borrelia burgdorferi"
|
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
