Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Spirochetes: Diverse and Unique |
| Discussion Leader: Linda Bockenstedt (Yale School of Medicine, USA) |
7:40 pm - 8:20 pm | Jorge Benach (Stony Brook University, USA) "The Characteristics
of the Outer Membrane of Borrelia burgdorferi Determine Its Ability to Thrive
in Different Environments" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Ben Adler (Monash University, Australia) "Leptospira Has Unique, but Largely Unknown, Virulence Factors and Cross-Protective Antigens" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Natasha Arora (Zurich Institute of Forensic Medicine, Switzerland) "Genomics of Syphilis" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Interactions of Spirochetes with the Host |
| Discussion Leader: David Haake (VA Greater Los Angeles Healthcare System / University of California, Los Angeles, USA) |
9:00 am - 9:20 am | Elsio Wunder (Yale School of Public Health, USA) "Novel Leptospiral Protein Involved in Dissemination and Virulence" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Tara Moriarty (University of Toronto, Canada) "Vascular Interaction Mechanisms of B. burgdorferi" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Patricia Rosa (Rocky Mountain Labs / National Institute of Allergy and Infectious Diseases, NIH, USA) "The Inexplicably Conserved OspC Signal Peptide: Form Ever Follows Function?" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:05 am | Brigette Church (University of Victoria, Canada) "Interaction of Treponema pallidum Pallilysin (Tp0751) with Human Platelets" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Utpal Pal (University of Maryland, College Park, USA) "Tick Immunity Impacting Persistence of Lyme Disease Pathogens" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Jennifer Caine (Medical College of Wisconsin, USA) "Borrelia burgdorferi Outer Surface Protein C Inhibits the Classical Complement Cascade by Binding C4b" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Hui Zhi (Texas A&M Health Science Center, USA) "Borrelia burgdorferi BbK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Immune Evasion and Persistence |
| Discussion Leader: Janis Weis (University of Utah, USA) |
7:30 pm - 7:50 pm | Peter Kraiczy (University Hospital of Frankfurt, Germany) "How Lyme Disease Spirochetes Trick Innate Immunity to Resist Complement Attack" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Nicole Baumgarth (University of California, Davis, USA) "B Cell Response Subversion Following Infection with Borrelia burgdorferi" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Robert Lochhead (Massachusetts General Hospital / Harvard Medical School, USA) "Innate and Adaptive Immune Activation in Antibiotic-Refractory Lyme Arthritis Illumintated by High-Throughput RNA and microRNA Sequencing of Patient Synovial Tissue" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Adriana Marques (National Institute of Allergy and Infectious Diseases, NIH, USA) "Searching for Persistence in Lyme Disease" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Environmental Sensing and Responses |
| Discussion Leader: Scott Samuels (University of Montana, USA) |
9:00 am - 9:20 am | Mathieu Picardeau (Institut Pasteur, France) "Comprehensive Analysis of Leptospiral Exoproteins" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Richard Marconi (Virginia Commonwealth University Medical Center, USA) "Unraveling the Genetic Regulatory Mechanisms of Treponema denticola: Insight into Its Unique Ability to Thrive in Periodontal Pockets" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Paula Schlax (Bates College, USA) "mRNA Sequence and Structure Influences Translational Regulation and mRNA Decay in Borrelia burgdorferi and Leptospira interrogans" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:05 am | Ariel Mechaly (Institut Pasteur de Montevideo, Uruguay) "Crystal Structure of the Hybrid Response Regulator LIC11708, a Virulence Factor of Leptospira interrogans" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Brian Stevenson (University of Kentucky, USA) "Metabolic Sensing, Signal Transduction, and Gene Regulation by the Lyme Disease Spirochete" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Nadia Benaroudj (Institut Pasteur, France) "The Peroxide Stress Regulator PerR of Leptospira interrogans Is a New Paradigm for Oxidative Stress Sensing and Adaptation" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Christian Eggers (Quinnipiac University, USA) "Phage-Mediated Exchange of Both Phage and Non-Phage DNA Among Borrelia burgdorferi Isolates" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Physiology, Membrane Biology, and Structural Biology |
| Discussion Leader: Melissa Caimano (University of Connecticut, USA) |
7:30 pm - 7:50 pm | Alejandro Buschiazzo (Institut Pasteur de Montevideo, Uruguay) "An Extra Twist in Leptospira Flagella: Filament Structure, Flagellin, and Beyond" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Christine Jacobs-Wagner (Yale University, USA) "Insights into the Cell Biology of Borrelia burgdorferi" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Michael Norgard (University of Texas Southwestern Medical Center, USA) "Biophysical and Biochemical Approaches for Discerning Unique Features of the Treponema pallidum Periplasm and Their Relationship to Syphilis Pathogenesis" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Chris Kenyon (Institute of Tropical Medicine Antwerp, Belgium) "Phosphorylations and Methylations in the Treponema pallidum Proteome" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Attachment, Invasion, Dissemination, and Persistence |
| Discussion Leader: Sven Bergstrom (Umeå University, Sweden) |
9:00 am - 9:20 am | John Leong (Tufts University School of Medicine, USA) "Role of the Major Outer Surface Protein OspC During Mammalian Infection by the Lyme Disease Spirochete" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Kristel Lourdault (University of California, Los Angeles / VA Greater Los Angeles Healthcare System, USA) "Using Tn-Seq to Identify Novel Leptospira interrogans Virulence Factors" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Jenny Hyde (Texas A&M Health Science Center, USA) "Elucidation of B. burgdorferi In Vivo Gene Expression" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Job Lopez (Baylor College of Medicine, USA) "Understanding Salivary Gland Colonization and Transmission of Relapsing Fever Spirochetes" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Célia Fontana (Merial / Institut Pasteur, France) "A Spontaneous Mutation in fliM Causes an Endoflagella Assembly Defect Resulting in Loss of Both Motility and Virulence in Leptospira interrogans" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Michael Curtis (Medical College of Wisconsin, USA) "Exploring the Roles of P66 During Borrelia burgdorferi Mammalian Infection" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Tao Lin (University of Texas Health Science Center at Houston, USA) "Borrelia burgdorferi Flagella Export Apparatus and Virulence: Insights into Type III Secretion System" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Pathogen Recognition and Inflammation |
| Discussion Leader: Peter Kraiczy (University Hospital of Frankfurt, Germany) |
7:30 pm - 7:50 pm | Catherine Werts (Institut Pasteur, France) "Leptospiral Cell Wall Specificities as Means of Escape from TLR and NLR Innate Immune Responses" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Kishore Alugupalli (Thomas Jefferson University, USA) "Altered Recognition of Borrelia hermsii Results in Dysregulated Inflammation and Lethality During Relapsing Fever" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Tanja Petnicki-Ocwieja (Tufts University School of Medicine, USA) "AP-3 Mediated Trafficking of B. burgdorferi Controls Specificity of Inflammatory Responses but Not TLR2 Adaptor Complex Assembly" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Joao Pedra (University of Maryland School of Medicine, USA) "Non-Canonical Activation of the Immune Deficiency Pathway in Ticks" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Spirochete Interception and Disease Prevention |
| Discussion Leader: Adriana Marques (National Institute of Allergy and Infectious Diseases, NIH, USA) |
9:00 am - 9:20 am | Linden Hu (Tufts University, USA) "Vector Targeted Approaches to Prevention of Lyme Disease" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Caroline Cameron (University of Victoria, Canada) "Protection from Syphilis Infection: Could It Be Mission Possible?" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Kathryn Hacker (Yale University, USA) "Rodent Population Dynamics and Leptospirosis Infection in Urban Slum Environments" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:05 am | Lee Oliver (Virginia Commonwealth University, USA) "An OspA and OspC Epitope Based 'Chimeritope' Provides Protection Against Tick Challenge in Canines: Progress Towards the Development of a Vaccine for Lyme Disease in Humans" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Alan McBride (Federal University of Pelotas (UFPel), Brazil) "LigB Subunit Vaccine Against Leptospirosis Confers Sterilizing Immunity in Hamsters" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Joppe Hovius (Academic Medical Center, The Netherlands) "In Search of an Antidote Against Tick-Borne Diseases" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Hari Hara Potula (University of Tennessee Health Science Center, USA) "Vaccination with LigA-Expressing Lactobacillus Rescues Disease Readouts in a Sublethal Mouse Model of Infection and Suggests that Leptospira Infection May Prevent Expansion of Memory Cells" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Spirochetes as Members of Microbial Consortia |
| Discussion Leader: Jared Leadbetter (California Institute of Technology, USA) |
7:30 pm - 7:50 pm | David Hampson (Murdoch University, Australia) "Brachyspira: Spirochetes that Chose the Colon" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Sukanya Narasimhan (Yale University, USA) "'Micro' Management in the Tick Gut - Impact on Borrelia burgdorferi" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Chris Li (State University of New York at Buffalo, USA) "Flagellar Glycosylation - A New Tale of Treponema denticola" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Jae Min Shin (University of Michigan School of Dentistry, USA) "Behavior of Green Fluorescence-Expressing Treponema denticola in Oral Biofilms" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |