| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: The Wide World of Spirochetes |
| Discussion Leaders: Brandon Jutras (Howard Hughes Medical Institute / Yale University, USA) and Hannah Wilder (Baylor College of Medicine, USA) |
| 3:45 pm - 3:50 pm | Introduction by Discussion Leader |
| 3:50 pm - 4:20 pm | Alan Barbour (University of California, Irvine, USA)
"Borrelia: A Mirror to Host Immunity" |
| 4:20 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Diversity of Spirochete Virulence and Adaptation |
| Discussion Leaders: Elsio Wunder (Yale School of Public Health, USA) and Philip Adams (University of Central Florida College of Medicine, USA) |
| Diversity of Spirochete Virulence |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 7:50 pm | Kristel Lourdault (University of California, Los Angeles / VA Greater Los Angeles Healthcare System, USA)
"Using Tn-Seq to Identify Novel Leptospira interrogans Virulence Factors" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Trever Smith (The University of Texas at San Antonio, USA)
"Borrelia Host-Adaptation Protein (BadP) Contributes to the Virulence of the Agent of Lyme Disease" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Karen Lithgow (University of Victoria, Canada)
"Molecular Mechanisms for the Treponema pallidum Protein Pallilysin (Tp0751) in Adhesion to the Vascular Endothelium" |
| 8:25 pm - 8:30 pm | Discussion |
| Diversity of Spirochete Adaptation |
| 8:30 pm - 8:35 pm | Introduction by Discussion Leader |
| 8:35 pm - 8:50 pm | Jae Min Shin (University of Michigan School of Dentistry, USA)
"Treponema denticola in Oral Biofilms" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Haritha Adhikarla (Yale University, USA)
"A Novel Dyad of Sensor Histidine Kinases, Lgr, Serves as a Global Regulator of Expression and Governs Virulence and Environmental Adaptation for the Leptospira Pathogen" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Ashley Groshong (University of Connecticut Health Center, USA)
"Redundancy and Precision for Amino Acid Acquisition: Evaluation of the Oligopeptide System in Borrelia burgdorferi" |
| 9:25 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Diversity of Spirochete Pathogenesis and Frontiers in Spirochete Research |
| Discussion Leaders: Sarah Whiteside (University of Utah, USA) and Christopher Pappas (Manhattanville College, USA) |
| Diversity of Spirochete Pathogenesis |
| 9:00 am - 9:05 am | Introduction by Discussion Leader |
| 9:05 am - 9:20 am | Klemen Strle (Massachusetts General Hospital, Harvard Medical School, USA)
"Differences Between European and North American Strains of Borrelia Species in Lyme Borreliosis Severity and Disease Manifestation" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:40 am | Kelly Hawley (University of Connecticut Health Center, USA)
"Human Macrophage Polarization Enhances Opsonophagocytosis and Inflammatory Response to the Stealth Pathogen, Treponema pallidum" |
| 9:40 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Annukka Pietikainen (University of Turku, Finland)
"Studies on Dissemination of Lyme Borreliosis in Mice Using Positron Emission Tomography/Computed Tomography (PET/CT) Imaging" |
| 9:55 am - 10:00 am | Discussion |
| Frontiers in Spirochete Research |
| 10:00 am - 10:05 am | Introduction by Discussion Leader |
| 10:05 am - 10:20 am | Dhruv Vig (Johns Hopkins University, USA)
"Modeling Lyme Disease: From Single Cell to Pathogen-Host Interactions" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:40 am | Martin Strnad (Biology Centre CAS, Czech Republic)
"Correlative Cryo-Fluorescence and Cryo-Scanning Electron Microscopy as a Straightforward Tool to Study Host-Pathogen Interactions" |
| 10:40 am - 10:45 am | Discussion |
| 10:45 am - 10:55 am | Rhodaba Ebady (University of Toronto, Canada)
"A Catch Bond Mechanism Promotes Bacterial Vascular Interactions Under Hydrodynamic Flow" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Career Development Panel |
| Discussion Leaders: Brian Leydet (Trudeau Institute, USA) and Brandee Stone (University of North Dakota, USA) |
| 1:30 pm - 1:35 pm | Introduction by Discussion Leader |
| 1:35 pm - 2:30 pm | Panel Discussion |
| "Finding Your Way in the Wide World of Spirochete Research" |
|
- Brandon Jutras (Howard Hughes Medical Institute / Yale University, USA)
- Martin Kintrup (Viramed Biotech AG, Germany)
- Claudia Molins (Centers for Disease Control and Prevention, USA)
- Samuel Perdue (National Institute of Allergy and Infectious Diseases, NIH, USA)
- Steven Projan (MedImmune, USA)
- Patricia Rosa (Rocky Mountain Labs / National Institute of Allergy and Infectious Diseases, NIH, USA)
- Christopher Pappas (Manhattanville College, USA)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
