Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Mechanisms of Spirochete Pathogenesis
Discussion Leader: Ryan Rego (Institute of Parasitology, Biology Centre CAS, Czech Republic)
3:45 pm - 4:20 pm
Patricia Rosa (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Transmission of the Lyme Disease Spirochete Borrelia burgdorferi : Tricky Business"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Niche and Biological Diversity of Spirochetes
Discussion Leaders: Kathryn Hacker (Yale University, USA) and Annukka Pietikainen (University of Turku, Finland)
7:30 pm - 7:50 pm
Yijie Deng (Virginia Commonwealth University, USA)
"Study of Virulence Factors that Protect Treponema denticola from Innate Immune Attacks"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Haritha Adhikarla (Yale University, USA)
"The Enigma of Magnesium Transport: Missing Link to Virulence in Pathogenic Leptospira "
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Vanessa Ante (Texas A&M Health Science Center, USA)
"Borrelia burgdorferi Adenylate Cyclase, CyaB, Alters Regulation of Virulence Determinants and Is Required for Murine Infection"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Peter Motyka (Northern Arizona University, USA)
"Modeling Vertebrate Community Structure and the Ecology Borrelia hermsii "
9:20 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Mechanisms of Virulence and Disease / Mentorship Component: Career Panel
Discussion Leaders: Karen Lithgow (University of Victoria, Canada), Michael Pereira (Tufts University School of Medicine, USA) and Brandon Jutras (Howard Hughes Medical Institute / Yale University, USA)
9:00 am - 9:20 am
Ignacio Santecchia (Institut Pasteur, France)
"Leptospira interrogans Escape of Autophagy as an Intracellular Survival Strategy"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Brigette Church (University of Victoria, Canada)
"Interaction of Treponema pallidum with Human Platelets"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
Sarah Whiteside (University of Utah, USA)
"TLR2-Dependent Bystander Activation of T Cells Drives Persistent Lyme"
10:00 am - 10:05 am
Discussion
10:05 am - 11:00 am
Panel Discussion
Life After Training
Robert Gaultney (Institut Pasteur, France)
Kaaren Janssen (Cold Spring Harbor Laboratory Press (Retired), USA)
Robert Lochhead (Massachusetts General Hospital / Harvard Medical School, USA)
Muhammad Morshed (University of British Columbia, Canada)
Patricia Rosa (National Institute of Allergy and Infectious Diseases, NIH, USA)
Scott Samuels (University of Montana, USA)
Elsio Wunder (Yale School of Public Health, USA)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
The Next Frontiers: Emerging Areas of Spirochete Research
Discussion Leaders: Alex Wagemakers (VU University Medical Center, The Netherlands) and Christina Savage (University of Kentucky, USA)
1:30 pm - 1:45 pm
Joris Koetsveld (Academic Medical Center, The Netherlands)
"Borrelia miyamotoi : Exploring an Emerging Tick-Borne Pathogen"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Fabiana Ferreira (Butantan Institute, Brazil)
"Identification and Functional Characterization of Leptospira interrogans Proteins as New Adhesins and Potential Antigens for Vaccine and Diagnosis"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Muhammed Saad Moledina (University of Toledo, USA)
"Intravital Microscopy Reveals that Innate, Not Adaptive, Immune Responses Are Primarily Responsible for Controlling Borrelia burgdorferi During Acute and Persistent Infection"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
