Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Rats, Rain and Leptospirosis
Discussion Leader: Lauren Farris (Texas A&M University, United States)
3:45 pm - 4:20 pm
Albert Ko (Yale School of Public Health, United States)
"Rats, Rain and Leptospirosis - Graduate Students Making a Difference Through Research in Urban Slum Communities"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unravelling Host-Spirochete Interactions to Prevent Disease
Discussion Leader: Peter Gwynne (Tufts School of Medicine, United States)
7:30 pm - 7:45 pm
Alexandra Powell (Texas A&M Health Science Center, United States)
"Classical Complement Pathway Evasion in Lyme Disease Spirochetes, Borrelia miyamotoi , and Tick-Borne Relapsing Fever Borrelia"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Kathryn Hayes (Virginia Polytechnic Institute and State University, United States)
"A Large-Scale Drug Screen Identifies Novel Therapeutics that Target the Syphilis Pathogen Treponema pallidum "
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Mecaila McClune (Virginia Polytechnic Institute and State University, United States)
"Uncovering the Relationship Between Borrelia burgdorferi Peptidoglycan and Lyme Disease Pathogenesis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Julie Cagliero (Institut Pasteur de Nouvelle Calédonie, New Caledonia)
"Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4/TRIF Signaling"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Anya O'Neal (University of Maryland School of Medicine, United States)
"CD36 Homologs Determine Microbial Resistance to the Lyme Disease Spirochete in Evolutionarily Distant Species"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Karukriti Ghosh (Yale School of Public Health, United States)
"First Evidence of Cross-Protection Against Death and Renal Colonization Caused by Leptospirosis Using a Multi-Recombinant Protein Vaccine"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Spirochete Genomics, Gene Regulation and Physiology
Discussion Leader: Alexandre Giraud-Gatineau (Institut Pasteur, France)
9:00 am - 9:15 am
Tatiana Castro-Padovani (University of Kentucky, United States)
"Borrelia burgdorferi Gac Protein Binds Specifically to DNA Adjacent to the ospC Promoter"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Samuel Garcia Huete (Institut Pasteur, France)
"Coping Well with Stress: Leptospira Response to Oxidants and the Role of Peroxide Stress Regulators"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Constantin Takacs (Stanford University, United States)
"Organization of the Highly Segmented Genome of Borrelia burgdorferi , the Lyme Disease Spirochete"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Luis Guilherme Fernandes (Instituto Butantan, Brazil)
"Gene Silencing of LipL32 and LigA/LigB by CRISPR-Interference in Leptospira interrogans and Virulence Evaluation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Aaron Brock (Virginia Polytechnique Institute and State University, United States)
"The Role of Motility in Borrelia burgdorferi Peptidoglycan Biosynthesis and Architecture"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Alex Kneubehl (Baylor College of Medicine, United States)
"Comparative Genomics of Borrelia turicatae and Borrelia venezuelensis : Two Sides of the Same Coin?"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Spirochete Virulence and Survival Strategies
Discussion Leader: Kerstin Ackermann (Equine Clinic of Ludwig-Maximilians-University, Germany)
1:30 pm - 1:45 pm
Tara Reid (University of Washington, United States)
"Novel Tp Specific T Cell Antigens"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Nadja Leimer (Northeastern University, United States)
"Diversity in ATP Concentrations at the Level of Single Borrelia Cells and its Impact on Antibiotic Survival"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Delphine Bonhomme (Institut Pasteur, France)
"TLR2/TLR4 Activation by Leptospiral LPS Promotes p62/NRF2 Axis Hence Reducing Autophagy and Preventing Cell Death in Murine Macrophages"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
