Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Mechanosensing and Mechanotransduction
Discussion Leaders: Bradford Berk (University of Rochester Medical Center, United States) and B. Rita Alevriadou (University at Buffalo-SUNY, United States)
7:40 pm - 8:25 pm
Ellie Tzima (University of Oxford, United Kingdom)
"Plexin D1 as a Mechanosensor"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Christopher Chen (Boston University , United States)
"Regulating Vascular Function through Pushes and Pulls"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cardiovascular Mechanosensing
Discussion Leaders: Rob Krams (Qmul, United Kingdom) and Kimiko Yamamoto (The University of Tokyo, Japan)
9:00 am - 9:20 am
Martin Schwartz (Yale School of Medicine, United States)
"Shear Stress Signaling at Cell-Cell Junctions"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
David Beech (University of Leeds, United Kingdom)
"PIEZO1 Force sensor in Physical Exercise and Cardiovascular Health and Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Cheng Zhu (Georgia Institute of Technology, United States)
"Catch Bonds and Their Significance of in Vascular Biology and Disease"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Bradford Berk (University of Rochester Medical Center, United States)
"Flow Mediated Vascular Remodeling is Regulated by Endothelial Translational Mechanisms"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Eno Ebong (Northeastern University, United States)
"Endothelial Cell Mechanobiology in Vascular Biology and Disease: Role of the Glycocalyx"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Irena Levitan (University of Illinois at Chicago, United States)
"Kir Channels Couple Endothelial Glycocalyx to Akt1/eNOS Activation in Flow Mechanotransduction: Role in Hypertension"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Kimiko Yamamoto (The University of Tokyo, Japan)
"Emerging Roles of Plasma Membranes and Mitochondria in Vascular Endothelial Mechanosensing"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jing Zhou (Peking University , China)
"The Endothelial Discoidin Domain Tyrosine Kinase Receptor 1 Senses Flow to Initiate Atherosclerosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Eno Ebong (Northeastern University, United States) and Manu Platt (National Institutes of Health, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dynamics of Cardiovascular Disease and Hemodynamics
Discussion Leaders: W. Robert Taylor (Emory University School of Medicine, United States) and Stephanie Lehoux (McGill University, Canada)
7:30 pm - 7:50 pm
Peter Stone (Brigham & Women's Hospital, Harvard Medical School, United States)
"The Plaque Hypothesis: Fundamental Pathobiology of Coronary Atherosclerosis and Clinical Implications for Chronic Ischemic Heart Disease Management"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Lucas Timmins (Texas A&M University, United States)
"Patient-Specific Modeling of the Coronary Artery Biomechanical Environment in the Setting of Uncertainty"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
Noelia Grande Gutiérrez (Carnegie Mellon University, United States)
"Image-Based Modeling of Coronary Hemodynamics and Transport for Coronary Artery Disease Assessment"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Brenda R. Kwak (University of Geneva, Switzerland)
"Oscillatory Shear Stress Augments Endothelial Pannexin1 by Inhibiting Macro-Autophagy"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
Lakshmi Dasi (Georgia Institute of Technology, United States)
"Heart Valve Blood Flow and Shear Stress Distributions: Impact of Anatomical and Hemodynamic Factors"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Lauranne Maes (KU Leuven, Belgium)
"Computational Study of Tissue-Scale and Cell-Scale Adaptive Processes in the Pulmonary Autograft after the Ross Procedure"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biomechanics and Mechanobiology of Aneurysms and Heart Valves
Discussion Leaders: Michael Sacks (University of Texas at Austin, United States) and Brenda R. Kwak (University of Geneva, Switzerland)
9:00 am - 9:20 am
W. Robert Taylor (Emory University School of Medicine, United States)
"The Role of PGC-1a in the Formation of Abdominal Aortic Aneurysms"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jay Humphrey (Yale University, United States)
"Biomechanics and Mechanobiology of Aortic Aneurysms"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Anne Robertson (University of Pittsburgh, United States)
"On the Mechanobiology of Cerebral Aneurysms Blebs"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Netanel Korin (Technion- Israel Institute of Technology, Israel)
"Biophysical Targeted based Drug Delivery to Brain Aneurysms"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Kartik Balachandran (University of Arkansas, United States)
"Early Calcific Aortic Valve Disease Progression in a Dynamic Valve-on-Chip Microphysiological System"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Michael Sacks (University of Texas at Austin, United States)
"A Full 3D Computational Model of the Contracting AVIC"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Jonathan Butcher (Cornell University, United States)
"Mechanobiological Switches in the Development of Embryonic Valves"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Joshua Hutcheson (Florida International University, United States)
"Cellular Heterogeneity in Aortic Valve Patterning"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Najma Latif (Magdi Yacoub Institute, Imperial College London, United Kingdom)
"Neuronal Regulation of the Pulmonary Root in Normal And Tissue Engineered Valves"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanical Forces and Atherosclerosis
Discussion Leaders: Anthony Passerini (University of California, Davis, United States) and John Shyy (University of California, San Diego, United States)
7:30 pm - 7:45 pm
Paul Evans (Queen Mary University of London, United Kingdom)
"Shear Stress, Atherosclerosis and Developmental Genes"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Yun Fang (University of Chicago, United States)
"Precision Nanomedicine Targeting Novel Endothelial Mechano-Sensing Mechanisms to Treat Vascular Diseases"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Wayne Orr (LSU Health Shreveport, United States)
"Nonproteolytic Ubiquitination in the Endothelial Response to Flow"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
John Shyy (University of California, San Diego, United States)
"Flow Regulation of Glycolysis in Endothelium"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
B. Rita Alevriadou (University at Buffalo-SUNY, United States)
"Role of Mitochondrial Ca2+ in EC Function under Shear Stress"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Li Zhu (Soochow University, China)
"Expression of Endothelial CCRL2 by Disturbed Flow Promotes Atherosclerosis: a Novel Chemerin-Dependent Monocytic ß2 Integrin Activation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanosignal Transduction in Vasculture and Heart Valves
Discussion Leaders: Guillermo Garcia-Cardena (Harvard Medical School, United States) and Luke Brewster (emory, United States)
9:00 am - 9:20 am
Manu Platt (National Institutes of Health, United States)
"Accelerated Elastin and Collagen Remodeling in Sickle Cell Disease: Biomechanical and Biochemical Stimuli"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Peter Yingxiao Wang (University of Southern California, United States)
"Mechanogenetics for the Remote and Noninvasive Control of Cellular Functions"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Luke Brewster (emory, United States)
"Interplay of Mechanical Forces on Endothelial Cell Behavior--Implications for Discovery in Peripheral Arterial Disease"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 10:55 am
Jeng-Jiann Chiu (National Health Research Institutes, Taiwan)
"Vinculin Phosphorylation Impairs Vascular Endothelial Junctions Promoting Atherosclerosis Associated with Disturbed Flow"
10:55 am - 11:00 am
Discussion
11:00 am - 11:15 am
Guillermo Garcia-Cardena (Harvard Medical School, United States)
"Flow-Dependent Programs and Endothelial Vasoprotection"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Stephanie Lehoux (McGill University, Canada)
"Atherosclerosis Regression Process"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Stephen White (Newcastle University , United Kingdom)
"Elevated Flow Evokes a Distinct Phenotypic Response in Human Coronary Artery Endothelial Cells - Implications for Plaque Biology"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Chiara Bellini (Northeastern University, United States)
"Chronic Exposure to Electronic Cigarette Aerosols Promotes Endothelial Dysfunction and Structural Stiffening of the Murine Aorta"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Jungkyu (Jay) Kim (University of Utah, United States)
"A Biomimetic Heart Valve Chip: Exploring Mechanobiological Impacts on Valvular Cell Behavior"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Plaque, Aneurysm Rupture, and Cardivoascular Events
Discussion Leaders: Martin Bennett (University of Cambridge, United Kingdom) and Ton van der Steen (Erasmus MC, The Netherlands)
7:30 pm - 7:45 pm
Martin Bennett (University of Cambridge, United Kingdom)
"Causes and Effects of Increased Plaque Structural Stress"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Tríona Lally (Trinity College Dublin, Ireland)
"Imaging Carotid Plaque Structure to Help Predict Rupture"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Jolanda Wentzel (ErasmusMC, Rotterdam, NL, The Netherlands)
"Influence of Multidirectional Wall Shear and Structural Stress on Plaque Progression of Different Phenotype in Human Coronary Arteries."
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Goo Taeg Oh ( Ewha Womans Univerusity, South Korea)
"Smooth Muscle Cell Specific Mitochondrial Dysfunction Exacerbates Abdominal Aortic Aneurysm"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Danny Bluestein (Stony Brook University, United States)
"AI-Enhanced Shear-Mediated Platelet Adhesion Dynamics and Thrombus Formation: In Vitro Validated Multiscale Simulations Using Coarse-Grained Molecular Dynamics and Dissipative Particle Dynamics"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Richard Leask (McGill University, Canada)
"Including Biomechanics and Machine Learning in a Thoracic Aortic Clinic"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cardiovascular Biomechanics - Imaging and Emerging Topics
Discussion Leaders: Elizabeth Jones (KU Leuven, Belgium) and John Oshinski (Emory University, United States)
9:00 am - 9:20 am
Frank Gijsen (Erasmus Medical Center, The Netherlands)
"A Human Disease Model for Atherosclerotic Plaque Rupture"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Craig Goergen (Purdue University, United States)
"Insights Into Murine Aortic Dissection Intramural Thrombi via Volumetric Ultrasound and Scanning Electron Microscopy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
AJIT YOGANATHAN (Georgia Tech, United States)
"Mechanics and Biology of Aortic Valve Leaflet Thrombosis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Peter Weinberg (Imperial College London, United Kingdom)
"Effects of Flow on Paracellular Permeability of Endothelium"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Elizabeth Jones (KU Leuven, Belgium)
"Integrating Mechanical Microenvironments; the Interplay of Shear Stress, Tissue Stiffness and Gene Expression"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Stefania Nicoli (Yale University, United States)
"The Hidden Life of Untranslated mRNAs at Local Adhesions"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Guohao Dai (Northeastern University, United States)
"Sox17 Mediates Adult Arterial Endothelial Cell Adaptation to Hemodynamics"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Luis Cardoso (City College of New York, United States)
"Effect of Microcalcifications on Plaque Rupture Risk"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Alexander Cartagena-Rivera (National Institute of Biomedical Imaging and Bioengineering, United States)
"Viscoelastic Property and Barrier Role of the Glycocalyx in Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cardiovascular Biomechanics and Mechanobiomedicine - Emerging Topics
Discussion Leaders: Zorina Galis (National Institutes of Health, United States) and Eno Ebong (Northeastern University, United States)
7:30 pm - 7:40 pm
Mabruka Alfaidi (LSU Health – Shreveport, United States)
"The Interleukin-1 Signaling in Disturbed Flow-Induced Endothelial Reprogramming"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Juan Jiménez (University of Massachusetts - Amherst, United States)
"Low Frequency Vibrations Induce Loss of on Endothelial Junction Integrity"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Bhama Ramkhelawon (New York University Langone Medical Center, United States)
"Force Activated Tensions in Abdominal Aortic Aneurysms"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Jennifer Chung (University of Toronto, Canada)
"Magnetic Resonance Imaging for Aortic Biomechanics to Evaluate Risk of Aortic Dissection"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Renita Horton (University of Houston, United States)
"Designing Cardiovascular Disease"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Tamar Wissing (Erasmus Medical Center, Rotterdam, The Netherlands., The Netherlands)
"A Human Disease Model for Atherosclerosis to Elucidate the Interplay between Plaque Biology and Mechanics"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Cassandra Clift (Harvard Medical School / Brigham and Women's Hospital, United States)
"Integration of Cellular Proteomics and Vesiculomics to Assess 3D Bioprinted Model of Calcific Aortic Valve Disease"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Hoda Hatoum (Michigan Technological University, United States)
"Hemodynamic Interplay of Blood Pressure, Valve Performance and Epicardial Coronary Flow"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure