Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
7:40 pm - 8:10 pm
"Common Pitfalls in Preclinical Cancer Target Validation"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Harnessing the Paracrine-cGAMP-STING Pathway for the Treatment of Cancer and Autoimmunity"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Short Talk Selected from Poster Abstracts
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
AI, Evolution and Systems Chemical Biology
9:00 am - 9:20 am
"Proteomics Across Deep Evolutionary Time to Decode Human Genetics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Expansion of the Ligandable Proteome Through AI-Driven Proteome-Wide Reactive Fragment Screening"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Programmable Biosynthesis of New-to-Nature Small Molecules"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Identification of Protein Misfolding Inhibitors by Directed Evolution"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Chemical Proteomic Approaches to Study Post-Translational and Pharmacological Landscapes of Immune Dysfunction"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Tripping Hypae and Remodeling Cell Walls with Chemical Glycobiology"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"30 Years of Covalent Probes Targeting Hydrolases: From 'Tools' to Imaging Agents"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"State-Dependent Ligand and Target Discovery in Cells"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
NGS-Based Chemical Biology
9:00 am - 9:20 am
"Pushing the Boundaries of Synthetic Biology"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Navigating the Proteome with Induced Proximity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Sequence Space Exploration in Phosphotyrosine Signaling Proteins"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"A High-Throughput Synthetic Biology and Chemistry Platform for Building Small Molecule Correctors"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Poster Previews
11:45 am - 12:05 pm
"Parallel Methods for Studying Signaling Enzyme Function and Druggability"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Control of Nucleic Acid Function
7:30 pm - 7:50 pm
"The Secret Building Blocks of RNA: From Decoding to Therapeutic Harnessing"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Circular RNAs in Health & Disease"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Enabling Technologies for Revealing Druggable Paths in RNA Biology"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"GlycoRNAs and Cell Surface RNA Biology"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Imaging and Molecular Detection
9:00 am - 9:20 am
"Visualizing Living Systems with Shortwave Infrared Light"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Imaging Tools and Technologies Inspired by Nature’s Light-Emitting Chemistry"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"New Enzyme Chemistry to Decipher Post-Translational Modification Function"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Imaging and Engineering the Central Dogma"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Engineering Synthetic Interfaces for Noninvasive Control and Monitoring of the Brain"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Illuminating Acetyl-CoA in Live Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Chemistry-Enabled Biological Discovery in Metabolism and Aging"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Novel Approaches to Modulating Mitochondrial Metabolism"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Biocatalysis and Complex Molecule Synthesis"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Translational Chemical Biology
9:00 am - 9:20 am
"Expanding the Alphabet and Topology of Synthetic mRNAs for Therapeutics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Chemical Degradation of N-Myc for the Treatment of Pediatric Neuroblastoma"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Chemoproteomic Strategies for Studying (de)ISGylation Pathways"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Small Molecule Inhibitors of Aberrant Chromatin Association in AML"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Targeting Histone Lysine Acetylation in Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"A Novel and High Throughput Chemoproteomic Platform to Identify Druggable Pockets and Chemical Probes for Classically Intractable Proteins"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proximity-Induced Modalities
7:30 pm - 7:50 pm
"Rewriting Protein Modifications in Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Reimagining Druggability Using Chemoproteomic Platforms"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Modularity in Therapeutic Design"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure