| SUNDAY, JULY 4 |
EVENING |
| THE PTH RECEPTOR: STRUCTURAL MOTIFS FOR HORMONE RECOGNITION AND SIGNAL TRANSDUCTION |
Discussion leader: Robert Nissenson, San Francisco, CA
- Michael Rosenblatt, Boston, MA
"Building an experimentally-derived model of ligand-receptor complexes in the PTH-PTHrP system."
- Thomas Gardella, Boston, MA
"Molecular analysis of the PTH-PTH Receptor Interaction."
- Caroline Silve, Paris, France
"Inhibitory mutations in Blomstrand Chondrodysplasia: characterization and consequences."
| MONDAY, JULY 5 |
MORNING |
| DIFFERENTIATION OF THE OSTEOCLAST |
Discussion leader: Tatsuo Suda, Tokyo, Japan
- David Lacey, Thousand Oaks, CA
"Mechanisms of Osteoprotegerin Ligand (ODF, TANCE, RANKL) Effects on Osteoclast Differentiation,
Activation, and Survival."
- Naoyuki Takahashi, Tokyo, Japan
"Regulatory mechanism of osteoclast differentiation and function by TNF ligand family members."
- Brendan Boyce, San Antonio, TX
"NF-kappa B signaling in bone cells as a determinant of bone mass."
- Ji Li, Thousand Oaks, CA
"Absolute requirement for the TNFR-related protein RANK during osteoclastogenesis and in regulation of bone mass and calcium metabolism."
- Ichiro Nakamura, Merck Research Laboratories, West Point
"Role of vß3 integrin in osteoclast migration and formation of the sealing zone."
| MONDAY, JULY 5 |
EVENING |
| SIGNALING IN THE OSTEOCLAST |
Discussion leader: Gideon Rodan, West Point, PA
- Gideon Rodan: Introductory remarks: "Integrins and Signalling."
- Roland Baron, New Haven, CT
"Signaling events involved in integrin activation and osteoclast motility."
- Le Duong, West Point, PA
"Src-dependent signaling of alpha v beta 3 integrin in osteoclasts."
- Carol Pilbeam, Farmington, CT: Poster presentation.
| TUESDAY, JULY 6 |
MORNING |
| TRANSCRIPTIONAL CONTROL OF OSTEOBLAST AND CHONDROCYTE DIFFERENTIATION AND FUNCTION |
Discussion leader: Gerard Karsenty, Houston, TX
- Richard Behringer, Houston, TX
"The role of Sox9 in cartilage formation."
- Patricia Ducy, Houston, TX
"Analysis of osteoblast differentiation and function."
- Gary Stein, Worcester, MA
"Interrelationships of nuclear structure with bone tissue-specific transcription."
- Thomas M. Aberg, Helsinki, Finland
- Seuwen Klaus, Basel, Switzerland
- Wendy Turner, London, England
- Michael Amling, Hamburg, Germany
| TUESDAY, JULY 6 |
EVENING |
| PROTEASES IN CARTILAGE AND BONE |
Discussion leader: Stephen Krane, Boston, MA
- Stephen Krane: Introduction: "Metalloproteinasses in bone development and remodeling."
- Zena Werb, San Francisco, CA
"Angiogenesis during bone formation."
- Henning Birkedahl-Hansen, Bethesda, MD
"The role of MT 1-MMP in skeletal growth and development."
| WEDNESDAY, JULY 7 |
MORNING |
| STRATEGIES FOR MANIPULATING BONE MASS HUMAN SKELETAL DISORDERS |
Discussion leader: Steven Goldring, M.D., Boston, MA
- Graham Russell, Sheffield, UK
"Bisphosphonates: is the odyssey over?"
- Francis Glorieux, Montreal, Canada
"Bisphosphonate use during growth: the lessons from the Osteogenesis Imperfecta trial."
- Arun Shanbhag, Boston, MA
"Bisphosphonates-Role of orthopaedic peri-implant osteolysis and ingrowth"
- Darwin Prockop, Philadelphia, PA
"Bone marrow transplantation as treatment of osteogenesis imperfecta."
- Theresa Guise, San Antonio, TX
"Evidence for a causal role of tumor-produced endothelin-1 in osteoblastic bone metastases."
| WEDNESDAY, JULY 7 |
EVENING |
| CRANIOFACIAL HARD TISSUE MORPHOGENESIS |
Discussion leader: Paul Sharpe, London, UK
- Paul Sharpe
"Making faces: the origins of instructive information determining facial hard tissue formation."
- Fred Jones, San Diego, CA
"Molecular insights into Barx protein function."
- Jill Helms, San Francisco, CA
"Sticks, stones and broken bones: the role of angiogenesis in skeletal development and repair."
- Tom Schilling, London, UK
"Genetic Analysis of Cartilage Patterning in the Zebrafish Embryo."
- Rene D'Souza, Houston, TX
"The role of Cbfa 1 in tooth development"
- David Rice, Helsinki, Finland
"FGFs and twist in calvarial bone and suture development."
- Yong-Xing Zhou, Bethesda, MD
"A proline to arginine substitution at codon 252 in FGFR1 promotes premature intramembranous ossification and results in Pfeiffer syndrome."
| THURSDAY, JULY 8 |
MORNING |
| DEVELOPMENT OF BONE AND CARTILAGE |
Discussion leader: Henry Kronenberg, Boston, MA
- Norbert Perrimon, Boston, MA
"The role of Drosophila Ext in Hedgehog signaling."
- Dominique Stickens, Dallas, TX
"The molecular and functional genetics of the exostosins."
- George Minowada, San Francisco, CA
"Vertebrate Sproutys in Bone Development."
- Rose Serra, Nashville, TN
"The role of TGF-beta in development and maintenance of cartilage"
- Thorsten Schinke, Houston, TX
"Genetic analysis of matrix GLA protein and osteocalcin in controlling extracellular matrix mineralization."
| THURSDAY, JULY 8 |
EVENING |
| KEYNOTE SPEAKER |
- Cliff Tabin, Dept of Genetics, Harvard Medical School, Boston MA
"Patterning the chick embroyo."
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