| SUNDAY, AUGUST 19 |
| 7:30 - 9:30 pm | CRANIOFACIAL HARD TISSUE MORPHOGENESIS |
| Discussion Leader: Irma Thesleff, Helsinki, Finland |
| 7:30 - 7:40 | Irma Thesleff
Introductory remarks |
| 7:40 - 8:00 | Bjorn Olsen, Boston, MA
"Genetic control of bone homeostasis" |
| 8:00 - 8:10 | Discussion |
| 8:10 - 8:20 | Stan Gronthos, Bethesda, MD
"Human adult dental pulp stem cells (DPSC): Identification and characterization by cDNA microarray analysis" |
| 8:20 - 8:25 | Discussion |
| 8:25 - 8:45 | William Philbrick, New Haven, CT
"Tooth versus bone: Survival in a hostile environment" |
| 8:45 - 8:55 | Discussion |
| 8:55 - 9:05 | Yu-Hsiung Wang, Farmington, CT
"Roles of pathways regulated by FGFs and BMPs in the morphogenesis of developing chick mandible" |
| 9:05 - 9:10 | Discussion |
| 9:10 - 9:30 | Karen Lyons, Los Angeles, CA
"To be or not to be a BMP: divergent roles for BMP3 in skeletal development" |
| 9:30 - 9:40 | Discussion |
| MONDAY, AUGUST 20 |
| 9:00 am - 12:30 pm | SECRETED MOLECULES IN SKELETON DEVELOPMENT AND PHYSIOLOGY |
| Discussion Leader: Lee Niswander, New York, NY |
| 9:00 - 9:10 | Lee Niswander
Introductory Remarks |
| 9:10 - 9:45 | Rudi Balling, Neuherberg, Germany
"Large scale ENU mutagenesis in mice" |
| 9:45 - 10:00 | Discussion |
| 10:00 - 10:15 | Coffee Break |
| 10:15 - 10:25 | Shannon Fisher, Baltimore, MD
"Genetic control of skeletogenesis in the zebrafish" |
| 10:25 - 10:30 | Discussion |
| 10:30 - 11:00 | David Ornitz, St. Louis, MO
"FGF and FGF receptor signaling in skeletal development" |
| 11:00 - 11:15 | Discussion |
| 11:15 - 11:25 | Dorothy Frenz, Bronx, NY
"Regulation of otic capsule chondrogenesis: a role for BMP4" |
| 11:25 - 11:30 | Discussion |
| 11:30 - 12:00 | Henry Kronenberg, Boston, MA
"Signaling pathways triggered by PTHrP in vivo" |
| 12:00 - 12:15 | Discussion |
| 4:30 - 6:00 p.m. | Poster Session |
| 7:30 - 9:30 pm | DEVELOPMENTAL BIOLOGY OF SKELETON |
| Discussion Leader: David Kingsley, Stanford, CA |
| 7:30 - 7:40 | David Kingsley
Introductory Remarks |
| 7:40 - 8:00 | Veronique Lefebvre, Cleveland, OH
"The transcription factors L-Sox5 and Sox6 are essential for chondroblast differentiation" |
| 8:00 - 8:10 | Discussion |
| 8:10 - 8:20 | Fanxin Long, Cambridge, MA
"Tissue-specific knockout of smoothened reveals a critical role for hedgehog signaling in chondrocyte proliferation" |
| 8:20 - 8:25 | Discussion |
| 8:25 - 8:45 | Robert Maxson, Los Angeles, CA
"Interaction between Twist and Msx2 in cranial suture morphogenesis" |
| 8:45 - 8:55 | Discussion |
| 8:55 - 9:05 | Wendy Turner, London, UK
"Bone morphogenetic proteins are potent osteogenic agents that are known to stimulate bone formation in vitro and in vivo and induce the osteoblastic commitment of MSC" |
| 9:05 - 9:10 | Discussion |
| 9:10 - 9:30 | Randall Dahn, Madison, Wisconsin
"Compartments and boundaries: limb skeletal morphogenesis beyond the zpa" |
| 9:30 - 9:40 | Discussion |
| TUESDAY, AUGUST 21 |
| 9:00 am - 12:30 pm | PHYSIOLOGY AND PHARMACOLOGY OF BONE REMODELING |
| Discussion Leader: Shigeaki Kato, Tokyo, Japan |
| 9:00 - 9:10 | Shigeaki Kato
Introductory Remarks |
| 9:10 - 9:45 | William Chin, Indianapolis, IN
"Novel coactivators in gene activation in bone and other tissues" |
| 9:45 - 10:00 | Discussion |
| 10:00 - 10:15 | Coffee Break |
| 10:15 - 10:25 | Carol Pilbeam, Farmington, CT
"BMP-2 induces COX-2 in osteoblasts via a Cbfa1 binding site: Role in osteoblast and osteoclast differentiation and in ectopic bone formation" |
| 10:25 - 10:30 | Discussion |
| 10:30 - 11:00 | Michele Resche-Rigon, Romainville, France
"Estrogens control of bone homeostasis in females: What did we learn from the analysis of Era, Erb and double knockout mice?" |
| 11:00 - 11:15 | Discussion |
| 11:15 - 11:25 | Amit M. Deshpande, Farmington, CT
"Identification of EDR3, a candidate gene for the Cornelia-de Lange Syndrome (CDLS)" |
| 11:25 - 11:30 | Discussion |
| 11:30 - 12:00 | Michael Econs, Indianapolis, IN
"FGF23, PHEX and their role in phosphate homeostasis" |
| 12:00 - 12:15 | Discussion |
| 4:30 - 6:00 pm | Poster Session |
| 7:30 - 9:30 pm | TRANSCRIPTIONAL REGULATION OF CELL DIFFERENTIATION |
| Discussion Leader: Rene St-Arnaud, Montreal, Canada |
| 7:30 - 7:40 | Rene St-Arnaud
Introductory Remarks |
| 7:40 - 8:00 | Shigeaki Kato, Tokyo, Japan
"Function of nuclear in gene regulation" |
| 8:00 - 8:10 | Discussion |
| 8:10 - 8:20 | Kim C. Mansky, Columbus, OH
"Signal transduction cascade regulating the activity of the microphthalmia gene product, MITF" |
| 8:20 - 8:25 | Discussion |
| 8:25 - 8:45 | Matthew Gamble, New York, NY
"Mediating transcription by nuclear hormone receptors" |
| 8:45 - 8:55 | Discussion |
| 8:55 - 9:05 | Robert R. Eferl, Vienna, Austria
"Function of FRA-1 protein in bone cell differentiation" |
| 9:05 - 9:10 | Discussion |
| 9:10 - 9:30 | Benoit Coulombe, Montreal, Canada
"Mechanism of transcription initiation by mammalian RNA polymerase II" |
| 9:30 - 9:40 | Discussion |
| WEDNESDAY, AUGUST 22 |
| 9:00 am - 12:30 pm | EXTRACELLULAR REMODELING |
| Discussion Leader: Henning Birkedal-Hansen, Bethesda, MD |
| 9:00 - 9:10 | Henning Birkedal-Hansen
Introductory Remarks |
| 9:10 - 9:45 | Francesco Ramirez, New York, NY
"Elastic fibers in bone morphogenesis and growth" |
| 9:45 - 10:00 | Discussion |
| 10:00 - 10:15 | Coffee Break |
| 10:15 - 10:25 | Ann E. Canfield, Manchester, UK
"Investigation of the role of the serine protease HTRA in matrix calcification" |
| 10:25 - 10:30 | Discussion |
| 10:30 - 11:00 | Stephen M. Krane, Boston, MA
"Possible roles of MMP-13 in skeletal development and bone remodeling: Lessons from mice with MMP-13 null mutation" |
| 11:00 - 11:15 | Discussion |
| 11:15 - 11:45 | Gregory R. Mundy, San Antonio, TX
"The mevalonate pathway and bone formation" |
| 11:45 - 12:00 | Discussion |
| 12:00 - 12:10 | Brigitte Mueller, Berlin, Germany
"Genotypes affecting the expression of IL-1beta or IL-1Ra are associated with osteoarthritis" |
| 12:10 - 12:15 | Discussion |
| 4:30 - 6:00 pm | Poster Session |
| 7:30 - 9:30 pm | CALCIUM REGULATING HORMONES |
| Discussion Leader: Robert Nissenson, San Francisco, CA |
| 7:30 - 7:40 | Robert Nissenson
Introductory Remarks |
| 7:40 - 8:05 | Harald Juppner, Boston, MA
"Resistance to PTH: of PTH/PTHrP receptors, G proteins and genetic imprinting" |
| 8:05 - 8:15 | Discussion |
| 8:15 - 8:45 | Peter Rowe, London, UK
"Novel bone-renal molecular pathways and bone homeostasis: PHEX, FGF23, Stanniocalcin, MEPE, and binding proteins" |
| 8:45 - 8:55 | Discussion |
| 8:55 -9:15 | Edward M. Brown, Boston, MA
"The calcium-sensing receptor: Novel modulators and signaling pathways" |
| 9:15 - 9:30 | Discussion |
| THURSDAY, AUGUST 23 |
| 9:00 am - 12:30 pm | NEW DEVELOPMENT |
| Discussion Leader: Henry Kronenberg, Boston, MA |
| 9:00 - 9:10 | Henry Kronenberg
Introductory Remarks |
| 9:10 - 9:45 | David Kingsley, Stanford, CA
"Evolving the vertebrate skeleton" |
| 9:45 - 10:00 | Discussion |
| 10:00 - 10:15 | Coffee Break |
| 10:15 - 10:25 | Li Zheng, Boston, MA
"Sox9 and Nkx3.2 confer the competence for BMP dependent somatic chondrogenesis" |
| 10:25 - 10:30 | Discussion |
| 10:30 - 11:00 | Lee Niswander, New York, NY
"Skeletal morphogenesis - what can we learn from mutant mice and normal bats?" |
| 11:00 - 11:15 | Discussion |
| 11:15 - 11:25 | Millan Patel, Houston, TX
"Low bone mass and abnormal eye vascularization in mice lacking Lrp5, a Wnt signaling molecule" |
| 11:25 - 11:30 | Discussion |
| 11:30 - 12:00 | J. Carlos Izpisua Belmonte, San Diego, CA
"WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo" |
| 12:00 - 12:15 | Discussion |
| 4:30 - 6:00 | Poster Session |
| 7:30 - 9:30 pm | KEYNOTE SPEAKER |
| Gregory S. Barsh, Stanford, CA |
