| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | VITAMIN D |
| Discussion Leader: René St-Arnaud (Shriners Hospital for Children) |
| 7:30 pm - 7:40 pm | René St-Arnaud
Introductory remarks |
| 7:40 pm - 8:15 pm | Wes Pike (University of Wisconson-Madison)
"Vitamin D receptors: mechanisms of agonist and antagonist action" |
| 8:15 pm - 8:50 pm | John Adams (University of California, Los Angeles)
"Heterogenous nuclear ribonuclear proteins and heat shock proteins-70: novel regulators of vitamin D action and metabolism" |
| 8:50 pm - 9:25 pm | Paul MacDonald (Case Western Reserve University)
"Vitamin D-mediated transcription in osteoblasts" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | OSTEOBLAST SIGNALING |
| Discussion Leader: Vicki Rosen (The Forsyth Institute) |
| 9:00 am - 9:10 am | Vicki Rosen
Introductory remarks |
| 9:10 am - 10:00 am | Bernard Roelen (Netherlands Cancer Institute)
"BMP signaling in osteoblast differentiation" |
| 10:00 am - 10:15 am | Coffee Break |
| 10:15 am - 10:30 am | Anja Nohe (University of Western Ontario)
"Dynamics of BMP Receptors with Caveolae" |
| 10:30 am - 11:15 am | Elazar Zelzer (Harvard Medical School)
"The role of VEGF in bone development" |
| 11:15 am - 11:30 am | Alka Mansukhani (New York University School of Medicine)
"Responses to FGF Signaling in Osteoblasts" |
| 11:30 am - 12:15 pm | Jane Aubin (University of Toronto)
"Osteoblast developmental pathways" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SKELETAL DEVELOPMENT |
| Discussion Leader: Jane Aubin (University of Toronto) |
| 7:30 pm - 7:40 pm | Jane Aubin
Introductory remarks |
| 7:40 pm - 8:10 pm | Gerard Karsenty (Baylor College of Medicine)
"Novel regulator of osteoblast differentiation" |
| 8:10 pm - 8:25 pm | Millan Patel (Baylor College of Medicine)
"Regulation of Bone Formation by Wnt Signaling" |
| 8:25 pm - 8:55 pm | René St-Arnaud (Shriners Hospital for Children)
"The Integrin-Linked Kinase (ILK) signaling cascade in bone cells" |
| 8:55 pm - 9:25 pm | Kazuhisa Nakashima (Univ. of Texas MD Anderson Cancer Center)
"Roles of Osx in osteoblast differentiation" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | OSTEOCLASTS/BONE RESORPTION |
| Discussion Leader: Phil Osdoby (Washington University) |
| 9:00 am - 9:10 am | Phil Osdoby
Introductory remarks |
| 9:10 am - 10:00 am | Hal Broxmeyer (Indiana University School of Medicine)
"A role for SDF-1/CXCL12 and CXCR4 in the migration, homing, mobilization, and survival of hematopoietic stem and myeloid progenitor cells" |
| 10:00 am - 10:15 am | Coffee Break |
| 10:15 am - 10:30 am | Kim C Mansky (Ohio State University)
"Interactions between MITF and PU.1 Required for Osteoclast Differentiation" |
| 10:30 am - 11:15 am | Yousef Abu-Amer (Washington University)
"New advances in the regulation of osteoclastogenesis and inflammatory bone erosion" |
| 11:15 am - 11:30 am | Mary C Nakamura (University of California, San Francisco)
"The Signaling Adaptor Protein DAP12 Regulates Multinucleation During Osteoclast Development" |
| 11:30 am - 12:15 pm | Robert Jilka (University of Arkansas)
"Osteoclast lifespan in health and disease" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PARATHYROID HORMONE (PTH)/PTH-RELATED PROTEIN |
| Discussion Leader: Harald Jüppner (Massachusettes General Hospital) |
| 7:30 pm - 7:40 pm | Harald Jüppner
Introductory remarks |
| 7:40 pm - 8:10 pm | Andy Karaplis (McGill University)
"PTH, PTHrP, and their receptors: lessons from knockout mice and man" |
| 8:10 pm - 8:25 pm | Murat Bastepe (Massachusetts General Hospital)
"Autosomal dominant pseudohypoparathyroidism type-Ib (AD-PHP-Ib) is associated with a heterozygous ~3-kb deletion which likely disrupts a putative long-range imprinting control element of GNAS1, the gene encoding Gs-alpha" |
| 8:25 pm - 8:55 pm | Gino Segre (Massachusetts General Hospital)
"NHERF-mediated parathyroid hormone receptor signaling" |
| 8:55 pm - 9:25 pm | Peter Friedman (University of Pitttsburgh, School of Medicine)
"Cell- and ligand-specific regulation of PTH receptor activation and internalization" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TEETH/CRANIOFACIAL BIOLOGY |
| Discussion Leader: William Philbrick (Yale Univ. School of Medicine) |
| 9:00 am - 9:10 am | William Philbrick
Introductory remarks |
| 9:10 am - 9:45 am | Jukka Jernvall (University of Helsinki)
"Fossil teeth do tell tales about tooth ontogeny" |
| 9:45 am - 10:00 am | Tilmann Wurtz (Univ. of Massachusetts Med Center and Univ. Paris 7)
"Bone Marrow Development: Failure of the OP Rat Strain to Maintain Stem Cells" |
| 10:00 am - 10:15 am | Coffee Break |
| 10:15 am - 10:45 am | Rena D'Souza (University of Texas Medical School)
"Human tooth agenesis" |
| 10:45 am - 11:35 am | Paul Sharpe (Kings College)
"Dental Patterning" |
| 11:35 am - 11:50 am | Mina Mina (University of Connecticut Health Center)
"New Insight into Progenitor/StemCells in Dental Pulp by Using Col1a1-GFP Transgenes" |
| 11:50 am - 12:30 pm | Richard Maas (Harvard Medical School)
"Genetic approaches to craniofacial development" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GENETICS DETERMINANTS OF BONE MASS AND MINERAL METABOLISM |
| Discussion Leader: Michael Econs (Indiana Univ. School of Medicine) |
| 7:30 pm - 7:40 pm | Michael Econs
Introductory remarks |
| 7:40 pm - 8:10 pm | Mark Johnson (Creighton University)
"Lrp5 and Mechanosensation in Bone" |
| 8:10 pm - 8:25 pm | Anne Jacob (Washington University Medical School)
"Conditional Inactivation of FGFR1 in Collagen2a1-cre Expressing Lineage Results in Abnormal Long Bone Development" |
| 8:25 pm - 8:55 pm | Eileen Shore (University of Pennsylvania School of Medicine)
"G-protein mutations in an inherited disorder of ectopic ossification" |
| 8:55 pm - 9:25 pm | Wes Beamer (Jackson Laboratory)
"Use of mouse models to find genes affecting bone strength" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | EXTRACELLULAR MATRIX |
| Discussion Leader: Caroline Damsky (University of California, San
Francisco) |
| 9:00 am - 9:10 am | Caroline Damsky
Introductory remarks |
| 9:10 am - 10:00 am | Jill Helms (University of California, San Francisco)
"Stem cells in skeletal development and repair" |
| 10:00 am - 10:15 am | Coffee Break |
| 10:15 am - 10:30 am | Masaki Inada (Harvard Medical School)
"Missouri Variant of Human Spondyloepimetaphyseal Dysplasia (SEMDMO) Maps to MMP-13 Gene: the Mutation in the Pro-domain Results in Altered Secretion and Intracellular Autoactivation of MMP-13" |
| 10:30 am - 11:15 am | Pam Robey (NIDCR, NIH)
"Stem cells that make hard tissue" |
| 11:15 am - 11:30 am | Jae-Beom Kim (University of California, San Francisco)
"The Role Of Focal Adhesion Kinase in Osteoblast Differentiation Ex Vivo" |
| 11:30 am - 12:15 pm | Dan Rifkin (New York University Medical Center)
"Role of the latent TGF-ß binding proteins in TGF-ß function: LTBP-3 in bone biology" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEYNOTE SPEAKER |
| Keynote Speaker: Norbert Perrimon (Harvard Medical School) |
| 7:30 pm - 7:40 pm | Introduction: Bob Nissenson (University of California, San Francisco) |
| 7:40 pm | Norbert Perrimon (Harvard Medical School)
"The Drosophila RNAi genome project: Applications to the study of signal transduction pathways and cell biology" |
| 9:00 pm | Closing Party |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
