SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | SESSION 1: EPIGENETIC CONTROL IN SKELETAL BIOLOGY AND PATHOLOGY |
7:35 pm - 7:50 pm | Discussion Leader: Gary Stein (University of Massachusetts Medical School) |
7:50 pm - 8:15 pm | Anthony Imbalzano (University of Massachusetts Medical School) "The regulation of chromatin remodeling" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | James Davie (Manitoba Institute of Cell Biology) "Histone acetylation, methylation and phosphorylation in biological control" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Short Presentations |
| Jennifer Westendorf (The Mayo Clinic) "Histone deacetylases regulate Runx2 activity" |
| Helmtrud Roach (University of Southamption) "Loss of DNA methylation in articular chondrocytes: a cause of osteoarthritis?" |
9:20 pm - 9:30 pm | General Discussion |
9:30 pm | Welcome Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | SESSION 2: SKELETAL DEVELOPMENT |
9:00 am - 9:05 am | Discussion Leader: Bjorn R. Olsen (Harvard University) |
9:05 am - 9:45 am | Yingzi Yang (National Institutes of Health) "Wnt and hedgehog signaling in bone formation and homeostasis" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:35 am | Rudolf Grosschedl (Max Planck Institute for Immunobiology) "Role of Ebf2 in the osteoblast-dependent support of hematopoiesis" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:00 am | Coffee Break |
11:00 am - 11:40 am | Gerard Karsenty (Columbia University) "Endocrine regulation of energy metabolism by bones" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Short Presentations |
| Debbie Dao (University of Rochester) "Axin1+/-; Axin2-/- mice have profound developmental deformities of the axial skeleton" |
| Stefan Schulte-Merker (The Netherlands Institute for Developmental Biology) "Phenotypical and molecular analysis of the zebrafish stocksteif mutant implicates a role for retinoic acid and cyp26b1 in osteogenesis of the vertebral column" |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 (Poster Numbers 1-32, ODD numbers presenting from 4:00 pm -5:00 pm, EVEN Numbers presenting 5:00 pm - 6:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SESSION 3: THE CELL AND MOLECULAR BIOLOGY OF ORAL TISSUES |
7:30 pm - 7:35 pm | Discussion Leader: Martha J. Somerman (University of Washington) |
7:35 pm - 8:00 pm | Paul Sharpe (Kings College London) "Key regulators of tooth development and strategies for building a tooth" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Carolyn W. Gibson (University of Pennsylvania) "Enamel and amelogenins" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Malcolm L. Snead (University of Southern California) "Cell to matrix and matrix to mineral interactions in enamel formation: Can something so hard be made simpler?" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:15 pm | Short Presentation |
| Bo Hou (Harvard University) "The role of pkd1 in bone remodeling induced by mid-palatal suture expansion in mice" |
9:15 pm - 9:30 pm | General Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SESSION 4: BONE AND HEMATOPOIESIS |
9:00 am - 9:05 am | Discussion Leader: Paolo Bianco (Universita "La Sapienza") |
9:05 am - 9:45 am | Ana Cumano (Institute Pasteur) "A stromal cell population at the site of emergence of the hematopoietic stem cell" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:35 am | Fumio Arai (Keio University) "Regulation of the hematopoietic stem cell and its interaction with the osteoblastic niche" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:00 am | Coffee Break |
11:00 am - 11:40 am | Louise E. Purton (Massachusetts General Hospital) "Understanding the relationship between bone, hematopoiesis and disease" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Short Presentations |
| Elizabeth Sweeney (University of Pennsylvania) "Altered hypertrophic cartilage matrix in collagen x mice leads to hematopoietic defects" |
| Alessia Funari (Universita dell’Aquila) "Angiopoietin-1 expressing bone marrow stromal cells in the wall of marrow sinusoids" |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 (Poster Numbers 1-32, ODD numbers presenting from 5:00 pm - 6:00 pm, EVEN numbers presenting from 4:00 pm - 5:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SESSION 5: OSTEOIMMUNOLOGY |
7:30 pm - 7:35 pm | Discussion Leader: Brendan F. Boyce (University of Rochester) |
7:35 pm - 8:05 pm | Roberto Pacifici (Emory University School of Medicine) "T cells: unexpected players in estrogen deficiency and PTH induced bone loss" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Mary Beth Humphrey (University of California, San Francisco) "The role of co-stimulatory signals in osteoclast activation during normal and accelerated bone remodeling" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Short Presentations |
| Julia Charles (University of California, San Franscisco) "The role of the signaling adapter lat in osteoclastogenesis" |
| Yi-Ping Li (The Forsyth Institute) "The mechanism of rankl-evoked [ca2+]i oscillations mediated by rgs10 in osteoclast differentiation" |
9:15 pm - 9:30 pm | General Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SESSION 6: BONE METASTASES: INSIGHT INTO MECHANISMS AND NOVEL TREATMENTS |
9:00 am - 9:05 am | Discussion Leader: Theresa A. Guise (University of Virginia) |
9:05 am - 9:45 am | Olivier Peyruchaud (Universite Claude Bernard) "Targeting lysophosphatidic acid: a new approach for bone metastasis therapy" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:35 am | Yibin Kang (Princeton University) "Gene networks and tumor-stroma interactions in breast cancer bone metastasis" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:00 am | Coffee Break |
11:00 am - 11:40 am | Kenneth Pienta (University of Michigan) "Inhibition of cytokines to treat bone metastases in prostate cancer" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Short Presentations |
| Jacqueline Akech (University of Massachusetts Medical School) "Aggresive osteolysis by prostate cancer cells is correlated to runx2" |
| Khalid Mohammad (University of Virginia) "TGF-β receptor I kinase inhibitor reduces the development and progression of melanoma bone metastases" |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 (Poster Numbers 33-63, ODD numbers presenting from 4:00 pm - 5:00 pm, EVEN numbers presenting from 5:00 pm - 6:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SESSION 7: CALCIUM AND PHOSPHATE METABOLISM |
7:30 pm - 7:35 pm | Discussion Leader: Gordon J. Strewler (Harvard University) |
7:35 pm - 8:00 pm | Itaru Urakawa (Kirin Brewery) "Role of Klotho in FGF-23 function" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Beate K. M. Lanske (Harvard School of Dental Medicine) "FGF23: The master regulator of mineral homeostasis" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Jerry Feng (Baylor College of Dentistry) "DMP1 regulates phosphate through FGF23" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:10 pm | Short Presentation |
| Brian Foster (University of Washington) "Differential phosphate sensitivity in mineralized tissues of the root, cementum and dentin" |
9:10 pm - 9:30 pm | General Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 12:30 pm | SESSION 8: THE BIOLOGICAL BASIS OF BONE THERAPIES |
9:00 am - 9:05 am | Discussion Leader: Serge Ferrari (Geneva University Hospitla) |
9:05 am - 9:45 am | Fraser Coxon (University of Aberdeen) "Bisphosphonates and their analogues: modes of action and future prospects" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:35 am | Paul J. Kostenuik (Amgen) "RANK and RANKL inhibitors" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:00 am | Coffee Break |
11:00 am - 11:40 am | Jack Martin (St. Vincent’s Institute) "Cell and molecular pathways that build on the anabolic action of PTH" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Short Presentations |
| Frank H. Ebetino (Proctor and Gamble) "The mode of binding of nitrogen containing bisphosphonates in farnesyl diphosphate synthase" |
| Tripti Gaur (University of Massachusetts Medical School) "Absence of sfrp1, an antagonist of wnt signaling accelerates fracture healing" |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 (Poster Numbers 32-63, EVEN numbers presenting from 5:00 pm - 6:00 pm, ODD numbers presenting from 4:00 pm - 5:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:00 pm | KEYNOTE LECTURE |
7:30 pm - 8:30 pm | Jane Buikstra (Arizona State University) "Bioarcheology and the hidden truths of the skeleton" |
8:30 pm - 8:45 pm | Discussion |
8:45 pm - 9:00 pm | Closing Remarks |
9:00 pm | Closing Reception |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |