SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | CARTILAGE BIOLOGY AND DISEASE |
| Discussion Leader: Bjorn R. Olsen (Harvard University, Boston, MA) |
7:35 pm - 7:45 pm | Bjorn Olsen: Overview |
7:45 pm - 8:10 pm | Veronique Lefebvre (Cleveland Clinic, Cleveland, OH) "Roles of Sox genes in skeletogenesis" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Danny Chan (The University of Hong Kong, Hong Kong, China) "Mechanistic insights of an IHH mutation that causes digit abnormalities" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Lea Gunnell (University of Rochester Medical Center) "Tak 1 Regulates Cartilage and Joint Development" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Meina Wang (University or Rochester Medical Center) "Overexpression of β-catenin in intervertebral disc cells leads to severe destruction of intervertebral disc tissue which is completely reversed by deletion of the Mmp13 gene" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Welcome Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | SKELETAL DEVELOPMENT |
| Discussion Leader: Yingzi Yang (National Institute of Health, Bethesda, MD) |
9:00 am - 9:15 am | Yingzi Yang: Overview |
9:15 am - 9:45 am | Henry M. Kronenberg (Harvard University, Boston, MA) "The role of Gs alpha in osteoblast development" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Coffee Break |
10:15 am - 10:45 am | Xu Cao (University of Alabama at Birmingham, Birmingham, AL) "TGFβ-Induced Migration of BMSCs to Couple Bone Resorption and Formation" |
10:45 am - 11:00 am | Discussion |
11:00 am - 11:30 am | Roland E. Baron (Harvard University, Boston, MA) "Zinc Finger Protein 521: A new player in bone and cartilage" |
11:30 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Elazar Zelzer (Weizmann Institute of Science) "Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Xin Zhou (MD Anderson Cancer Center) "Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 (Poster Numbers 1-44, ODD numbers presenting from 4:00 pm - 5:00 pm, EVEN Numbers presenting from 5:00 pm - 6:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | DENTAL AND CRANIOFACIAL DEVELOPMENT |
| Discussion Leader: Laurie Kay McCauley (University of Michigan, Ann Arbor, MI) |
7:30 pm - 7:40 pm | Laurie Kay McCauley: Overview |
7:40 pm - 8:05 pm | Yang Chai (University of Southern California, Los Angeles, CA) "TGF-beta signaling and tooth development" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:45pm | Jan C. Hu (University of Michigan, Ann Arbor, MI) "Genetic basis of enamel and dentin defects" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Yuji Mishina (University of Michigan, School of Dentistry) "Smad-dependent BMP signaling through type IA receptor in cranial neural crest cells directs their cell fate towards chondrocytes" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Hwaseon Seo (University of Alabama at Birmingham) "Tgfbr2 is required for development of the parietal bone" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | GENETICS AND BONE DISEASES |
| Discussion Leader: Brendan Lee (Baylor College of Medicine, Houston, TX) |
9:00 am - 9:15 am | Brendan Lee: Overview |
9:15 am - 9:45 am | Fanxin Long (Washington University, St. Louis, MO) "Notch as a brake for bone formation" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Coffee Break |
10:15 am - 10:45 am | Daniel H. Cohn (University of California, Los Angeles, CA) "Calcium channel defects in the skeletal dysplasias" |
10:45 am - 11:00 am | Discussion |
11:00 am - 11:30 am | Valerie Cormier-Daire (INSERM, Paris, France) "From the identification of ADAMTS10 and ADAMTSL2 mutations to the TGFβ signalling pathway" |
11:30 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Leonie Huitema (Hubrecht Institute) "Genetic screens to identify gene functions essential for bone formation" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Michael Sohaskey (University of California) "Osteopotentia, a novel rER membrane protein, regulates osteoblast maturation and bone formation" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 (Poster Numbers 1-44, ODD numbers presenting from 5:00 pm - 6:00 pm, EVEN Numbers presenting from 4:00 pm- 5:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | BONE REPAIR AND REGENERATION |
| Discussion Leader: Regis J. O’Keefe (University of Rochester, Rochester, NY) |
7:30 pm - 7:40 pm | Regis J. O’Keefe: Overview |
7:40 pm - 8:05 pm | Johnny Huard (Children’s Hospital of Pittsburgh, Pittsburgh, PA) "Bone Repair and Regeneration through Muscle Stem Cell Transplantation" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Vicki Rosen (Harvard School of Dental Medicine, Boston, MA) "BMPs and fracture healing" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Eric Hesse (Harvard School of Dental Medicine) "Genetic Evidence of Runx2 Antagonism by Zfp521: Enhancement of the Cleidocranial Dysplasia Phenotype in Runx2 Heterozygous Mice and Partial Rescue of Long Bone Fractures in Col 1-Runx2 Transgenic Mice" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Christa Maes (K.U.Leuven) "Increased skeletal VEGF enhances beta-catenin activity and results in excessive ossification and disruption of the bone and marrow microenvironment" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | OSTEOIMMUNOLOGY |
| Discussion Leader: Yongwon Choi (University of Pennsylvania, Philadelphia, PA) |
9:00 am - 9:05 am | Yongwon Choi: Overview |
9:05 am - 9:35 am | Hiroshi Takayanagi (Tokyo Medical and Dental University, Tokyo, Japan) "New immune regulator of bone metabolism" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Coffee Break |
10:05 am - 10:35 am | Michael Cancro (University of Pennsylvania, Philadelphia, PA) "Bi-directional cross talk links osteoclastogenesis with long lived plasma cell differentiation" |
10:35 am -10:50 am | Discussion |
10:50 am - 11:20 am | Georg Schett (University of Erlangen-Nuremberg, Erlangen, Germany) "Control of bone mass by regulatory T cells" |
11:20 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Laura Maile (University of North Carolina at Chapel Hill) "Regulation of osteoclast formation by integrin associated protein" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Toshifumi Sugatani (Washington University School of Medicine) "Impaired MicroRNA Homeostasis Diminishes Osteoclast Formation and Activity" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Zhenqiang Yao (University of Rochester Medical Center) "Axis of TRAF3 and NF-kappa B2 p100 Limits TNF-Induced Osteoclastogensis" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 (Poster Numbers 45-88, ODD numbers presenting from 4:00 pm - 5:00 pm, EVEN Numbers presenting from 5:00 pm - 6:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | OSTEOBLASTIC AND HEMATOPOIETIC STEM CELLS |
| Discussion Leader: Paul J. Simmons (University of Texas, Houston, TX) |
7:30 pm - 7:40 pm | Paul J. Simmons: Overview |
7:40 pm - 8:05 pm | Linheng Li (Stowers Institute for Medical Research, Kansas City, MO) "The stem cell niche in bone" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Paolo Bianco (La Sapienza University, Rome, Italy) "Microvascular niches in hematopoietic and non-hematopoietic systems" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Christina Hammond (Hubrecht Institute) "Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signaling" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Sumithra Urs (Maine Medical Center Research Institute) "Sproutyl Expression Influences PPARγ- Dependent Allocation of Mesenchymal Stem Cell Populations" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:40 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 12:30 pm | THE BIOLOGICAL BASIS OF BONE THERAPIES |
| Discussion Leader: Sundeep Khosla (Mayo Clinic, Rochester, MN) |
9:00 am - 9:15 am | Sundeep Khosla: Overview |
9:15 am - 9:45 am | Thomas Clemens (University of Alabama at Birmingham, Birmingham, AL) "Insulin signaling in osteoblasts regulates bone and body composition" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Coffee Break |
10:15 am - 10:45 am | Mark Johnson (University of Missouri, Kansas City, MO) "Targeting the Wnt Pathway for Skeletal Anabolic Therapy; When, Where and How" |
10:45 am - 11:00 am | Discussion |
11:00 am - 11:30 am | Merry Jo Oursler (Mayo Clinic, Rochester, MN) "The osteoclast as a mediator of bone anabolism" |
11:30 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Joachim Albers (University Medical Center Hamburg) "Low bone formation and osteopenia in mice lacking the Wnt receptor Frizzled 9" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Jochen Schulze (UKE-University Medical Center Hamburg-Eppendorf) "Transgenic over-expression of the Wnt antagonist Kremen-2 in osteoblasts leads to severe impairment of bone formation and increased bone resorption" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 (Poster Numbers 45-88, EVEN numbers presenting from 5:00 pm - 6:00 pm, ODD Numbers presenting from 4:00 pm - 5:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:00 pm | ARRA - A PALINDROME OF OPPORTUNITY |
| Discussion Leader: Brendan F. Boyce (University of Rochester, Rochester, NY) |
7:30 pm - 8:30 pm | Stephen I. Katz (NIAMS, Bethesda, MD) |
8:30 pm - 8:45 pm | Discussion |
8:45 pm - 9:00 pm | Closing Remarks |
9:00 pm | Closing Reception |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |